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Bos, E.J.C. (author), Bullema, J.E. (author), Delbressine, F.L.M. (author), Schellekens, P.H.J. (author), Dietzel, A.H. (author), TNO Industrie en Techniek (author)Assembly is a crucial part in the realization of a product. Compared to assembly in the macro world, assembly in the micro world is influenced by scaling effects. These include surface forces, high requirements on placement uncertainty and small product dimensions. Conventional high-speed assembly in many cases utilizes suction grippers. However...article 2008
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Plak, R. (author), Gortzen, R.M.W. (author), Puik, E.C.N. (author), TNO Industrie en Techniek (author)During the placement of components in micro-assembly, high impact forces occur. The current approach is to reduce these impact forces by coupling the gripper to the drive unit of the placement device with 5 DOF, wherein the gripper that contacts the component has a relatively low mass. To prevent the gripper from bouncing back at the end of the...conference paper 2008
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Glycolipid-dependent sorting of melanosomal from lysosomal membrane proteins by lumenal determinantsGroux-Degroote, S. (author), van Dijk, S.M. (author), Wolthoorn, J. (author), Neumann, S. (author), Theos, A.C. (author), de Mazière, A.M. (author), Klumperman, J. (author), van Meer, G. (author), Sprong, H. (author), TNO Kwaliteit van Leven (author)Melanosomes are lysosome-related organelles that coexist with lysosomes in mammalian pigment cells. Melanosomal and lysosomal membrane proteins share similar sorting signals in their cytoplasmic tail, raising the question how they are segregated. We show that in control melanocytes, the melanosomal enzymes tyrosinase-related protein 1 (Tyrp1)...article 2008
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Bos, E.J.C. (author), Bullema, J.E. (author), Delbressine, F.L.M. (author), Schellekens, P.H.J. (author), Dietzel, A.H. (author), TNO Industrie en Techniek (author)Assembly is a crucial part in the realization of a product. Compared to assembly in the macro world, assembly in the micro world is influenced by scaling effects. These include surface forces, high requirements on placement uncertainty and small product dimensions. Conventional high-speed assembly in many cases utilizes suction grippers. However...conference paper 2008
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Kudryashova, E.V. (author), Visser, A.J.W.G. (author), de Jongh, H.H.J. (author), TNO Kwaliteit van Leven (author)In this study the relation between the ability of protein self-association and the surface properties at air-water interfaces is investigated using a combination of spectroscopic techniques. Three forms of chicken egg ovalbumin were obtained with different self-associating behavior: native ovalbumin, heat-treated ovalbumin-being a cluster of 12...article 2005
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Rensen, P.C.N. (author), van Dijk, K.W. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)Chemicals / CAS: lipoprotein lipase, 83137-80-8, 9004-02-8; APOA5 protein, human; Apolipoproteins A; Apolipoproteins; Triglyceridesarticle 2005
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van Rhijn, J.W. (author), de Looze, M.P. (author), Tuinzaad, G.H. (author), Groenesteijn, L. (author), de Groot, M.D. (author), Vink, P. (author), TNO Work and Employment (author)Current assembly enterprises are under a lot of pressure, as they are faced with increasing volume demands and product variations, needs for shorter delivery times and cost reduction. This pressure is likely to increase the pressure on individual workers. In many small to medium-sized enterprises (SMEs), we observe that traditional assembly...article 2005
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Eikhout, S.M. (author), Helmes, R.B.M. (author), van Rhijn, J.W. (author)Due to fluctuations on the market, manufacturing of many product variations, and wish for fine-tuning between production and assembly a fan and motor manufacturing company wanted to improve their assembly line. The aims were efficient flow and human centered assembly in the new product line. Therefore an integral participatory approach of...conference paper 2004
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van Heijningen, M. (author), Gauthier, G. (author)This paper presents a novel approach to realize low-cost millimeter-wave modules using only SMD packaged MMICs integrated on a single organic substrate. This approach is demonstrated on a 38 GHz transceiver module for point-to-point LMDS communication systems. The required SMD package technology and demonstrator have been developed in the 5th...conference paper 2004
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de Looze, M.P. (author), van Rhijn, J.W. (author)The rhythm in assembly, defined as the repetitive pattern of actions in time, is increasingly recognized as a crucial factor in assembly. Rhythm includes aspects like cycle time, action variation, work content and work rest schemes, and it affects productivity, quality, worker's motivation and worker's health. By the organization of the assembly...conference paper 2004
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Vogels, R. (author), Zuijdgeest, D. (author), van Rijnsoever, R. (author), Hartkoorn, E. (author), Damen, I. (author), de Béthune, M.-P. (author), Kostense, S. (author), Penders, G. (author), Helmus, N. (author), Koudstaal, W. (author), Cecchini, M. (author), Wetterwald, A. (author), Sprangers, M. (author), Lemckert, A. (author), Ophorst, O. (author), Koel, B. (author), van Meerendonk, M. (author), Quax, P. (author), Panitti, L. (author), Grimbergen, J. (author), Bout, A. (author), Goudsmit, J. (author), Havenga, M. (author)Replication-deficient human adenovirus type 5 (Ad5) can be produced to high titers in complementing cell lines, such as PER.C6, and is widely used as a vaccine and gene therapy vector. However, preexisting immunity against Ad5 hampers consistency of gene transfer, immunological responses, and vector-mediated toxicities. We report the...article 2003
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de Looze, M.P. (author), van Rhijn, J.W. (author), van Deursen, J. (author), Tuinzaad, G.H. (author), Reijneveld, C.N. (author)A participatory and integrative approach was applied to improve the productivity and ergonomics of the assembly lines in two factories, producing magnetic stop valves and office furniture, respectively. Main elements of the approach are the active participation of the company and the integration of two disciplines: assembly engineering and...article 2003
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van Lingen, P. (author), van Rhijn, G. (author), de Looze, M.P. (author), Vink, P. (author), Koningsveld, E. (author), Tuinzaad, G. (author), Leskinen, T. (author)Manufacturers of manually assembled products are increasingly being forced to improve the flow of assembly orders, together with having more efficient employment, in order to meet increasing demands on short delivery times, high product variety, good quality and low manufacturing costs. At the same time, the human factor is increasingly...article 2002
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Vink, P. (author), van Eijnatten, F.M. (author), TNO Arbeid (author)This paper describes the background and objectives of the IST project “Organizational Aspects of Human-Machine Coexisting Systems” (HUMACS), that develops and pilot-demonstrates a Participative Simulation environment for Integral (i.e., logistics, technology and human factors) Manufacturing enterprise renewal (PSIM). In the short run, HUMACS...bookPart 2002
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van Rhijn, J.W. (author), de Looze, M.P. (author), Groenesteijn, L. (author), de Groot, M.D. (author), Vink, P. (author), Tuinzaad, G.H. (author)A participatory and integrative approach was developed and applied to im­prove the productivity and ergonomics in assembly companies. Main ele­ments of the approach are the active participation of the company and the integration of two disciplines: assembly engineering and ergonomics. The aims were the analysis of bottlenecks of the...conference paper 2002
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de Looze, M.P. (author), van Rhijn, G. (author), Tuinzaad, B. (author), van Deursen, J. (author)Manufacturers of manually assembled products are more and more forced to improve the flow of assembly orders together with a more efficient employment, in order to meet increasing demands on short delivery times, high product variety, good quality and low manufacturing costs. At the same time, the human factor is increasingly important, for a...conference paper 2000
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van Deursen, J. (author), van Rhijn, J.W. (author), TNO Industrie en Techniek (author)De mate waarin bedrijven hun productieproces beheersen, bepaalt in hoeverre zij aan de steeds hogere eisen van hun klanten tegemoet kunnen komen. Ofwel, in hoeverre zij steeds meet productvarianten snel en concurrerend kunnen leveren bij een constante hoge kwaliteit. In productiebedrijven waar het assemblageproces overwegend handmatig gebeurt...article 1999
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van Oosterhout, G.P.C. (author), Blom, C.B.M. (author), Jovanovic, P.S. (author), TNO Bouw (author)The paper addresses observations of the structural behaviour of the Tweede Heine-noordtunnel, a shield-driven tunnel in typical Dutch soft soils. Two rings were equipped with structural monitoring instrumentation. The measurements have shown that the assembly of the rings causes very significant initial forces and moments in the segments....conference paper 1999
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Werij, H.G.C. (author), Olij, C. (author), Zoutman, A.E. (author), Kamp, A. (author), Technisch Physische Dienst TNO - TH (author)One of the instruments to be launched on ENVISAT around the turn of the century is the Scanning Imaging Absorption spectroMeter for Atmospheric Cartography (SCIAMACHY). This eight-channel spectrometer covers the wavelength range of 240 nm to 2385 nm and will allow the first space-borne simultaneous atmospheric measurements in the ultraviolet,...conference paper 1997
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Langerak, Edwin (author), TNO Milieu, Energie en Procesinnovatie (author)The recycling of mass consumer products like TV-sets and computers is gaining attention in Europe. The presence of (precious) metals traditionally has been the driving force for the recycling of equipment. While the plastics in electronics usually have a high quality, the recovery of them is problematic. In this paper the results are presented...conference paper 1997