The Development and Calibration of a Mechanistic Asbestos Removal Exposure Assessment Tool (AREAT)

Exposure to asbestos fibres is linked to numerous adverse health effects and the use of asbestos is currently banned in many countries. Still, asbestos applications are present in numerous residential and professional/industrial buildings or installations which need to be removed. Exposure measurements give good insight in exposure levels on the...

Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

The evidence for an association between occupational asbestos exposure and esophageal, gastric and colorectal cancer is limited. We studied this association specifically addressing risk differences between relatively low and high exposure, risk associated with cancer subtypes, the influence of potential confounders and the interaction between...

Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study

Objectives The evidence for an association between occupational asbestos exposure and pharyngeal cancer (PhC) is limited, while for oral cavity cancer (OCC) the literature is even sparser. We studied OCC and PhC risk both separately and combined (OCPC) in relation to occupational asbestos exposure, specifically addressing the influence of...

Policy expectations and the use of market mechanisms for regulatory OSH certification and testing regimes

Governments strive increasingly to reduce the 'burden of legislation' by shifting responsibilities to private institutions, thereby making use of 'the market' as regulating mechanism, and striving to base the relationship with industries on trust, rather then stringent enforcement. This makes mandatory certification and testing arrangements in...

Occupational exposure to silica and lung cancer risk in the Netherlands

Objectives: The lung cancer carcinogenicity of crystalline silica dust remains the subject of discussion. Epidemiological evidence is based on occupational cohort studies and population-based case-control studies. The aim of this study was to assess associations between male lung cancer risk and silica exposure in a population-based cohort study...

The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing...

A revised estimate of copper emissions from road transport in UNECE-Europe and its impact on predicted copper concentrations

Comparisons of measured and model-predicted atmospheric copper concentrations show a severe underestimation of the observed concentrations by the models. This underestimation may be (partly) due to underestimated emissions of copper to air. Since the phase out of asbestos brake lining material, the composition of brake lining material has...

Socioeconomic status and lung cancer incidence in men in The Netherlands: Is there a role for occupational exposure?

Study objective - To evaluate the influence of occupational exposure to carcinogens in explaining the association between socioeconomic status and lung cancer. Design - A prospective cohort study. Data on diet, other lifestyle factors, sociodemographic characteristics and job history were collected by means of a self administered questionnaire....

Pulmonary response of hamsters to fibrous glass: Chronic effects of repeated intratracheal instillation with or without benzo[a]pyrene

Syrian golden hamsters were given intratracheal instillations of glass fibres with or without benzo[a]pyrene suspended in saline, once a fortnight for 52 weeks. The experiment was terminated at week 85. 'Silicotic granulomas' consisting of tightly packed, iron-positive macrophages filled with glass fibres and surrounded by a layer of alveolar...

Elektronenmikroskopische Untersuchung von Asbestkörperchen und Asbestfasern in der Lunge eines Mesotheliom-Patienten [Investigation of asbestos bodies and asbestos fibers found in the lungs of a mesothelioma patient by electron microscopy]

Asbestos bodies and asbestos fibers were found in the lungs of a mesothelioma patient and analysed by electron microscopy. The bodies were normal asbestos bodies with amphibole-asbestos fibers as kernels. The free asbestos fibers, present in the lungs, mainly were chrysotile-asbestos. © 1973 Springer-Verlag. Chemicals/CAS: asbestos, 1332-21-4;...

Detection and measurement of the concentration of asbestos in air