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Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), de Knijff, P. (author), Stalenhoef, A.F.H. (author), Mol, M.J.T.M. (author), Gevers Leuven, J.A. (author), Smit, J. (author), Erkelens, D.W. (author), Schouten, J. (author), Frants, R.R. (author), Havekes, L.M. (author)
In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantly between the FH group and a sample group of the...
article 1990
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Instituut voor Toegepaste Radiobiologie en Immunologie TNO (author), van Beusechem, V.W. (author), Kukler, A. (author), Einerhand, M.P.W. (author), Bakx, T.A. (author), van der Eb, A.J. (author), van Bekkum, D.W. (author), Valerio, D. (author)
Amphotropic recombinant retroviruses were generated carrying sequences encoding human adenosine deaminase (ADA). Transcription of the human ADA gene was under control of a hybrid long terminal repeat in which the enhancer from the Moloney murine leukemia virus was replaced by an enhancer from the F101 host-range mutant of polyoma virus....
article 1990
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Gaubius instituut TNO (author), Princen, H.M.G. (author), Meijer, P. (author), Kuipers, F. (author)
Chemicals/CAS: Bile Acids and Salts; Solutions
article 1990
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Gaubius instituut TNO (author), van den Berg, E.A. (author), Le Clercq, E. (author), Kluft, C. (author), Koide, T. (author), van der Zee, A. (author), Oldenburg, M. (author), Wijnen TH., J. (author), Meera Khan, P. (author)
Histidine-rich glycoprotein (HRG) is a monomeric plasma glycoprotein involved in the modulation of coagulation and fibrinolysis. Using Southern analysis of human-rodent somatic cell hybrid DNA with a human HRG-specific cDNA probe, the HRG gene was assigned to chromosome 3. One hybrid that was known to contain only a segment of chromosome 3 also...
article 1990
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Odink, J. (author), Kramer, F.M. (author), van der Beek, E.J. (author), Thissen, J.T.N.M. (author), Kempen, H.J.M. (author), van den Berg, H. (author), Egger, R.J. (author), Wientjes, C.J.E. (author), CIVO-TNO Nederlands instituut voor praeventieve gezondheidszorg TNO, NIPG-TNO Gaubius instituut TNO, GI-TNO Instituut voor zintuigfysiologie TNO, IZF-TNO (author)
This study was designed to investigate the relation between fatty acid consumption, total plama cholesterol and neuroendocrine response to exposure to stress, factors thought to play a role in the development of coronary heart disease. For this purpose 32 apparently healthy male volunteers were classified on the basis of their plasma cholesterol...
article 1989
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Godthelp, J. (author), K├Ąppler, W.D. (author), Instituut voor Zintuigfysiologie TNO (author)
The time-to-line-crossing (TLC) concept has been used as a time-related measure to describe driving strategy. The purpose of this research is to analyze whether TLC might enlarge our understanding of the relationship between vehicle handling characteristics and a driver's looking and lateral control strategy in a straight-lane-keeping task....
article 1988
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Gaubius instituut TNO (author), Kempen, H.J.M. (author), Glatz, J.F.C. (author), Gevers Leuven, J.A. (author), van der Voort, H.A. (author), Katan, M.B. (author)
The power of serum lathosterol concentration as an indicator of whole-body cholesterol synthesis was investigated in 47 human volunteers consuming two diets differing in fatty acid composition. The cholesterol balance (fecal excretion of neutral and acid steroids minus cholesterol intake) was strongly correlated with the serum level of total ...
article 1988
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Medisch Biologisch Laboratorium TNO (author), Muijser, H. (author), Hoogendijk, E.M.G. (author), Hooisma, J. (author), Twisk, D.A.M. (author)
In a group of workers exposed to high levels of lead during five months nerve conduction velocity parameters were evaluated at the termination of exposure, and also three and fifteen months later. At the termination of exposure the mean blood lead level was 4.0 ??mol/l, and motor conduction velocities in the median and the ulnar nerves were...
article 1987
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van den Berg, H. (author), Louwerse, E.S. (author), Bruinse, H.W. (author), Thissen, J.T.N.M. (author), Schrijver, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The vitamin B6 status of women suffering from premenstrual symptoms (PMS, n = 19) and a group of matched controls (n = 19) has been investigated. The women volunteering in the study were selected on strictly defined criteria. Several biochemical parameters of the metabolism of vitamin B6 and tryptophan were studied in blood and urine samples...
article 1986
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Gaubius instituut TNO (author), Boks, A.L. (author), Brommer, E.J.P. (author), Schalm, S.W. (author), van Vliet, H.H.D.M. (author)
In a study of severe, decompensated liver failure, we tried to find a correlation between hemorrhage and parameters of hemostasis and fibrinolysis. Three groups of patients were studied: alcoholic cirrhosis; nonalcoholic cirrhosis, and acute liver failure without known prior liver disease. The two cirrhotic groups did not differ significantly...
article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Odink, J. (author), van der Beek, E.J. (author), van den Berg, H. (author), Bogaards, J.J.P. (author), Thissen, J.T.N.M. (author)
The effects of maximal performance capacity and different work load intensities on the response of free and sulfate-conjugated plasma catecholamines, prolactin (PRL), and cortisol were studied in six healthy male volunteers. In a first experiment, the volunteers had to perform a step-wise incremental bicycle ergometer test to determine the onset...
article 1986
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Kluft, C. (author), Verheijen, J.H. (author), Jie, A.F.H. (author), Rijken, D.C. (author), Preston, F.E. (author), Sue-Ling, H.M. (author), Jespersen, J. (author), Aasen, A.O. (author), Gezondheidsorganisatie TNO Gaubius Instituut TNO (author)
The plasma activity level of the recently discovered fast-acting inhibitor of tissue-type plasminogen activator (t-PA) was found to be temporarily increased after surgery, myocardial infarction and severe trauma. Detailed analysis of the postoperative period revealed simultaneously increased t-PA antigen and inhibition and decreased t-PA...
article 1985
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D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...
article 1985
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van Eeden, C.H. (author), de Jong, A.W.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The well-known Kroller method for the determination of cyanide requires the use of the harmful chemicals benzidine (carcinogenic) and bromine (toxic) in the colorimetric part; the analytical result depends strongly on the conduct of the liberation procedure. The substitution of barbituric acid and N-chlorosuccinimide for benzidine and bromine...
article 1985
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Schreurs, W.H.P. (author), Odink, J. (author), Egger, R.J. (author), Wedel, M. (author), Bruning, P.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Chemicals/CAS: Ascorbic Acid, 50-81-7; Calcifediol, 19356-17-3; Vitamin A, 11103-57-4; Vitamin B 12, 68-19-9; Vitamin E, 1406-18-4; Vitamins
article 1985
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Gaubius Instituut TNO (author), Kluft, C. (author), Jie, A.F.H. (author), Sprengers, E.D. (author), Verheijen, J.H. (author)
Inhibition of tissue-type plasminogen activator (t-PA) by pooled plasma could be ascribed for only 60% to the endothelial cell type PA inhibitor. The residual inhibition is ascribed to a so-far undescribed plasma component present at 0.2 nmol/l. This component shows reversible binding to t-PA with an apparent K(i) of 10 pmol/l (does not hinder t...
article 1985
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Centraal Instituut voor Voedingsonderzoek TNO (author), Kool, H.J. (author), Kuper, F. (author), van Haeringen, H. (author), Koeman, J.H. (author)
The carcinogenicity in male and female Wistar SSP TOX rats of organic drinking-water concentrates that are positive in the Ames test was studied at thr. Chemicals/CAS: Carcinogens, Environmental; Mutagens; Water Pollutants; Water Pollutants, Chemical.
article 1985
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Instituut voor Zintuigfysiologie TNO (author), Godthelp, J. (author)
This paper presents two experiments in which steering a lane-change manoeuvre is analysed as a precognitive control task. The suggestion that the dependence on instantaneous visual feedback is low during such a task was tested by analysing steering performance under conditions both with and without visual occlusion. Steering force served as the...
article 1985
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de Jonge, G. (author), Dienske, H. (author), Sanders-Woundstra, J.A.R. (author), Primatencentrum TNO (author)
A comparison was made between the behaviour of 61 severely socially deprived children and 41 controls during a psychiatric screening session. Ages ranged from 1.5 to 12 years. The occurrence of directly observable ethological categories of social interaction, activity and play was determined by use of a keyboard. Problem children differed from...
article 1984
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van der Beek, E.J. (author), Wedel, M. (author), van de Zedde, A. (author), Bovens, M. (author), Leep, B.J. (author), Hermus, R.J.J. (author), Schouten, J.A. (author), van der Veen, E.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Twenty seven male patients, with Type-I diabetes mellitus were studied, all from the Outpatient Clinic of the Department of Internal Medicine, the Free University Hospital, Amsterdam. In comparison with healthy subjects and as regards age, total cholesterol and LDL-cholesterol levels were within normal limits, although HDL-cholesterol and...
article 1984
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