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van Eeden, C.H. (author), de Jong, A.W.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The well-known Kroller method for the determination of cyanide requires the use of the harmful chemicals benzidine (carcinogenic) and bromine (toxic) in the colorimetric part; the analytical result depends strongly on the conduct of the liberation procedure. The substitution of barbituric acid and N-chlorosuccinimide for benzidine and bromine...
article 1985
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Schreurs, W.H.P. (author), Odink, J. (author), Egger, R.J. (author), Wedel, M. (author), Bruning, P.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Chemicals/CAS: Ascorbic Acid, 50-81-7; Calcifediol, 19356-17-3; Vitamin A, 11103-57-4; Vitamin B 12, 68-19-9; Vitamin E, 1406-18-4; Vitamins
article 1985
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Gaubius Instituut TNO (author), Kluft, C. (author), Jie, A.F.H. (author), Sprengers, E.D. (author), Verheijen, J.H. (author)
Inhibition of tissue-type plasminogen activator (t-PA) by pooled plasma could be ascribed for only 60% to the endothelial cell type PA inhibitor. The residual inhibition is ascribed to a so-far undescribed plasma component present at 0.2 nmol/l. This component shows reversible binding to t-PA with an apparent K(i) of 10 pmol/l (does not hinder t...
article 1985
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Centraal Instituut voor Voedingsonderzoek TNO (author), Kool, H.J. (author), Kuper, F. (author), van Haeringen, H. (author), Koeman, J.H. (author)
The carcinogenicity in male and female Wistar SSP TOX rats of organic drinking-water concentrates that are positive in the Ames test was studied at thr. Chemicals/CAS: Carcinogens, Environmental; Mutagens; Water Pollutants; Water Pollutants, Chemical.
article 1985
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Instituut voor Zintuigfysiologie TNO (author), Godthelp, J. (author)
This paper presents two experiments in which steering a lane-change manoeuvre is analysed as a precognitive control task. The suggestion that the dependence on instantaneous visual feedback is low during such a task was tested by analysing steering performance under conditions both with and without visual occlusion. Steering force served as the...
article 1985
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de Jonge, G. (author), Dienske, H. (author), Sanders-Woundstra, J.A.R. (author), Primatencentrum TNO (author)
A comparison was made between the behaviour of 61 severely socially deprived children and 41 controls during a psychiatric screening session. Ages ranged from 1.5 to 12 years. The occurrence of directly observable ethological categories of social interaction, activity and play was determined by use of a keyboard. Problem children differed from...
article 1984
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van der Beek, E.J. (author), Wedel, M. (author), van de Zedde, A. (author), Bovens, M. (author), Leep, B.J. (author), Hermus, R.J.J. (author), Schouten, J.A. (author), van der Veen, E.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Twenty seven male patients, with Type-I diabetes mellitus were studied, all from the Outpatient Clinic of the Department of Internal Medicine, the Free University Hospital, Amsterdam. In comparison with healthy subjects and as regards age, total cholesterol and LDL-cholesterol levels were within normal limits, although HDL-cholesterol and...
article 1984
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Centraal Instituut voor Voedingsonderzoek TNO (author), de Raat, W.K. (author), Willems, M.I. (author), de Meijere, F.A. (author)
It has been shown that the spontaneous revertants in the Ames test can depend on the amount and type of bottom agar on the plates. The most clear-cut effect was found with his G46 strains, carrying the ??uvrB mutation, and with the new hisG428 strain, TA102. Evidence of mutagenic impurities in agar has been found. Chemicals/CAS: agar, 9002-18-0;...
article 1984
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Nieuwenhuizen, W. (author), Haverkate, F. (author), Gaubius Instituut TNO (author)
Chemicals/CAS: fibrinogen, 9001-32-5; calcium, 7440-70-2; Calcium, 7440-70-2; Fibrinogen, 9001-32-5
article 1983
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Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Short-term tests designed to detect possible carcinogenicity have been extensively refined during the last years. Presently, many more or less simple and convenient systems are available to detect mutations, chromosome effects, DNA damage, and malignant transformation. Although their relevance to carcinogenicity is often reasonably good,...
article 1983
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Reuzel, P.G.J. (author), Feron, V.J. (author), Spit, B.J. (author), Beems, R.B. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and...
article 1983
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Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), de Boer, B.C.J. (author), van Faassen, A. (author), Pikaar, N.A. (author), Hermus, R.J.J. (author)
We suggest that a lower faecal pH may be correlated with a lower mortality of large-bowel cancer and that faecal pH should always be considered in epidemiological studies on the role of diet in colon carcinogenesis.
article 1983
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Verheijen, J.H. (author), Nieuwenhuizen, W. (author), Wijngaards, G. (author), Gaubius instituut TNO (author)
Tissue activator-mediated plasminogen activation is potentiated both by fibrin and by some soluble fibrin(ogen) fragments. The potentiating effect of the different fragments decreases in the order fibrin monomer > D-dimer > Y > D EGTA > Dcate > X. Fibrinogen and the fragments Ecate, E EGTA and E fibrin have almost no effect. The existence of a...
article 1982
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Speek, A.J. (author), van Schaik, F. (author), Schrijver, J. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A reliable high-performance liquid chromatographic (HPLC) method is developed for the analysis of FAD in whole blood of humans. The method is able to separate FAD, FMN and Rb from each other and from interfering compounds. A reliable and sensitive detection of FAD has been obtained by selecting the optimal pH of the mobile phase and optimal...
article 1982
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Medisch Biologisch Labortorium TNO (author), Polak, R.L. (author), Sellin, L.C. (author), Thesleff, S. (author)
The acetylcholine (ACh) content and spontaneous and evoked release of ACh in rat extensor digitorum longus (EDL) muscles were determined by pyrolysis mass fragmentography. The determinations were made on muscles paralysed by local application of botulinum toxin (BoTx) type A, on unpoisoned muscles, surgically denervated or reinnervated muscles....
article 1981
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Centraal Instituut voor Voedingsonderzoek TNO (author), Olsman, W.J. (author)
Soy protein is the vegetable protein that is most frequently used in meat products. Accordingly, detection and determination procedures have mainly been focused on soy proteins. Cereal proteins received far less attention analytically, let alone the less conventional vegetable proteins. Every method published has only a limited applicability,...
article 1979
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Bunt, A.A. (author)
Thirty-two subjects had tests of serial recall of visually presented nine-digit lists which were either presented in a single block of trials (constant context) or in between lists of much longer length (variable context). Other variables were vocalization-during-presentation versus silent memorization (within subject) and order of recall ...
article 1976
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Germans, F.H. (author), Koster, M.W. (author), Kwee, H.H. (author), Groep Motoriek Revalidatie, Medisch Fysisch Instituut TNO Instituut voor gezondheidstechniek TNO (author)
The merits of the 'vacuum form fixation' are discussed for the production of reliable body impressions of patients suffering from sitting problems. Impressions are taken with the patients seated in the desired posture. The first results are reported, obtained from 4 patients of different categories, fitted with individually moulded seats...
article 1974
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Bouman, M.A. (author), Walraven, P.L. (author), Instituut voor Zintuigfysiologie TNO (author)
On the basis of measurements of the achromatic zone for red light in the fovea and for green light in the periphery, a discussion is given on the possible difference in threshold mechanisms for the achromatic (scotopic) and chromatic (photopic) retinal systems. A specific suggestion for this distinction is given that not directly refers to the...
article 1972
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Bunt, A.A. (author), Sanders, A.F. (author)
An experiment is reported on the effects of cognitive similarity on proactive and retroactive interference (PI, RI) in short term memory. To avoid confounding between cognitive and acoustic similarity, the materials - i.e. words and digits - were matched with respect to vowel pattern. Effects of both PI and RI were found on recall of words,...
article 1972
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