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TNO-Institute of Animal Nutrition and Physiology (author), Schutte, J.B. (author), de Jong, J. (author), van Weerden, E.J. (author), van Baak, M.J. (author)1. Two experiments were conducted to examine the effect of feeding D-xylose and L-arabinose on broiler performance, body composition, caecal length and weight, and liver weight. 2. Graded amounts (25, 50 and 75 g/kg) of D-xylose or L-arabinose were added to either a practical type (Exp. A) or a semi-purified (Exp. B) basal diet. As reference, a...article 1992
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Theeuwes, J. (author)Three visual search experiments tested whether top-down selectivity toward particular stimulus dimensions is possible during preattentive parallel search. Subjects viewed multielement displays in which two salient items, each unique in a different dimension—that is, color and intensity (Experiment 1) or color and form (Experiments 2 and 3)—were...article 1991
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Roholl, P.J.M. (author), Weima, S.M. (author), Prinsen, I. (author), de Weger, R.A. (author), den Otter, W. (author), van Unnik, J.A.M. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO Instituut voor Experimentele Gerontologie TNO (author)The expression of both platelet-derived growth factor (PDGF) and epidermal growth factor (EGF), and of their receptors was examined immunohistochemically in a number of normal tissues as well as in benign and malignant mesenchymal tumors. The benign lesions studied were from the skin: palmar fibromatosis (fibroblastic) and from the uterus:...article 1991
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van Nesselrooij, J.H.J. (author), Bruijntjes, J.P. (author), Garderen van-Hoetmer, A. (author), Tillapaugh-Fay, G.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Estrogen-induced pituitary lesions in rats were studied in time-sequence experiments using magnetic resonance imaging (MRI), hormone determinations and light microscopy. The main purpose of the study was to evaluate the usefulness of MRI in comparison with conventional biochemical and histopathological methods for detecting the pituitary lesions...article 1991
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't Hart, B.A. (author), Botman, C.A.D. (author), Bakker, N.P.M. (author)Peripheral blood mononuclear cells (PBMC) from Rhesus monkeys previously immunized with bovine type II collagen to induce arthritis were cultured with the same antigen. Because the native protein is poorly soluble in culture medium a heating step is often used. The antigen in this form induced PBMC proliferation, but epitopes for the induction...article 1991
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Medisch Biologisch Laboratorium TNO (author), Mol, M.A.E. (author), Nanninga, P.B. (author), van Eendenburg, J.P. (author), Westerhof, W. (author), Mekkes, J.R. (author), van Ginkel, C.J.W. (author)Skin equivalents that consisted of a noncontracted collagen gel populated with allogeneic fibroblasts and covered with autologous cultured keratinocytes were used for grafting venous leg ulcers. The results were compared in the same patient with those obtained with a routinely used standard method of grafting with autologous full-thickness punch...article 1991
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TNO Human Factors (author), Marcus, J.T. (author), Toet, A. (author)The edges of straight bars in a square-wave luminance grating appear undulating to an observer when the retinal image of this pattern is in motion. The amplitude of the perceived undulations increases linearly with retinal image speed with an average slope of 30 ± 4 ms. The period of the motion-induced bulges is 2.5 ± 0.5° and shows no...article 1991
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van der Hoeven, N. (author), Hemerik, L. (author)A stochastic model is formulated to determine the optimal strategy for a solitary parasitoid which has discovered an already parasitized host. The model assumes that the parasitoid can count both the number of eggs already present in a host and the number of conspecifics searching in the same patch. The survival probability of an egg is assumed...article 1990
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Vos, J.J. (author), Estevez, O. (author), Walraven, P.L. (author), Instituut voor Zintuigfysiologie TNO (author)New action spectra are derived for the foveal cones on the basis of three assumptions: (1) the Stiles-Burch (1959) colorimetric data are better than CIE 1931; (2) the long wavelength flanks of the dichromatic luminosity functions offer better anchorage than the confusion loci; and (3) the relative mutual heights per receptor can be derived from...article 1990
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Fichtinger-Schepman, A.M.J. (author), Velde van der - Visser, S.D. (author), Dijk van - Knijnenburg, H.C.M. (author), van Oosterom, A.T. (author), Baan, R.A. (author), Berends, F. (author), TNO Voeding Medisch biologisch laboratorium TNO (author)During chemotherapy with a cisplatin-containing combination of drugs, 217 blood samples from 30 cancer patients were analyzed for the presence of the main cisplatin-DNA adduct cis-Pt(NH3)2d(pGpG) (Pt-GG). Cisplatin was administered during 3-h infusions on each of 5 consecutive days, resulting in increasing adduct levels which, on the average,...article 1990
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van 't Veer, P. (author), van der Wielen, R.P.J. (author), Kok, F.J. (author), Hermus, R.J.J. (author), Sturmans, F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The association between breast cancer and selenium, measured in the diet, plasma, erythrocytes, and toenails, was investigated in a case-control study in the Netherlands during 1985-1987. Dietary selenium intake was assessed by a structured dietary history technique among 133 breast cancer cases and 238 population controls. Absolute and energy...article 1990
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Havenith, G. (author), van Middendorp, H. (author)An experiment was set up to quantify the relative influence of fitness, acclimatization, gender and anthropometric measures on physiological responses to heat stress. For this purpose, 12 male and 12 female subjects were exposed to a neutral [ambient temperature (T(a)) 21°C, relative humidity (r.h. 50%)], a warm, humid (T(a) 34°C, r.h. 80%) and...article 1990
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Wertheim, A.H. (author), van Gelder, P. (author)When the eyes pursue a fixation point that sweeps across a moving background pattern, and the fixation point is suddenly made to stop, the ongoing motion of the background pattern seems to accelerate to a higher velocity. Experiment I showed that this acceleration illusion is not caused by the sudden change in (i) the relative velocity between...article 1990
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Bosland, M.C. (author), Prinsen, M.K. (author), Dirksen, T.J.M. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Carcinomas of the rat prostate induced by a single injection of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, after sequential treatment with cyproterone acetate and testosterone propionate, were evaluated as potential animal model for prostatic cancer. All ten carcinomas examined were located in the...article 1990
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Zoetelief, J. (author), Eisenhauer, C.M. (author), Coyne, J.J. (author)Displacement corrections for in-phantom measurements with ionisation cham- bers for the purpose of mammography are large and represent a major correction to consider for dose determinations. Experimental data on displacement corrections depend to a large degree on the model used to extrapolate to zero cavity radius. Calculations of displacement...article 1990
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Centraal Instituut voor Voedingsonderzoek TNO (author), Lina, B.A.R. (author), Dreef-Van Der Meulen, H.C. (author), Leegwater, D.C. (author)Neohesperidin dehydrochalcone was administered to groups of 20 male and 20 female Wistar rats at dietary levels of 0, 0.2, 1.0 and 5.0% for 91 days. No treatment-related ophthalmoscopical, haematological or histopathological effects were observed. In the high-dose group, a marked caecal enlargement occurred in both sexes, accompanied by soft...article 1990
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Centraal Instituut voor Voedingsonderzoek TNO (author), Stekelenburg, F.K. (author), Zomer, W.L. (author), Mulder, S.J. (author)A cooked haemoglobin medium was developed for the detection of hydrogen-peroxide-producing bacteria. The composition and preparation of this medium are described. The medium has proved to be an adequate medium for diagnosis of the greening of cooked cured meat products caused by hydrogen-peroxide-producing lactic acid bacteria.article 1990
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Gezondheidsorganisatie TNO Gaubius Instituut TNO (author), de Knijff, P. (author), Stalenhoef, A.F.H. (author), Mol, M.J.T.M. (author), Gevers Leuven, J.A. (author), Smit, J. (author), Erkelens, D.W. (author), Schouten, J. (author), Frants, R.R. (author), Havekes, L.M. (author)In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE) polymorphism on pre-treatment plasma lipid levels and on the response to treatment with simvastatin was studied. The apoE phenotype distribution did not differ significantly between the FH group and a sample group of the...article 1990
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Instituut voor Toegepaste Radiobiologie en Immunologie TNO (author), van Beusechem, V.W. (author), Kukler, A. (author), Einerhand, M.P.W. (author), Bakx, T.A. (author), van der Eb, A.J. (author), van Bekkum, D.W. (author), Valerio, D. (author)Amphotropic recombinant retroviruses were generated carrying sequences encoding human adenosine deaminase (ADA). Transcription of the human ADA gene was under control of a hybrid long terminal repeat in which the enhancer from the Moloney murine leukemia virus was replaced by an enhancer from the F101 host-range mutant of polyoma virus....article 1990
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Gaubius instituut TNO (author), Princen, H.M.G. (author), Meijer, P. (author), Kuipers, F. (author)Chemicals/CAS: Bile Acids and Salts; Solutionsarticle 1990