- document
-
Instituut voor Toegepaste Radiobiologie en Immunologie TNO (author), Schmidt, J. (author), Krump-Konvalinkova, V. (author), Luz, A. (author), Goralczyk, R. (author), Snell, G. (author), Wendel, S. (author), Dorn, S. (author), Pedersen, L. (author), Strauss, P.G. (author), Erfle, V. (author)hMt-c-fos-LTR transgenic mice (U. Ruther, D. Komitowski, F.R. Schubert, and E.F. Wagner. Oncogene 4, 861-865, 1989) developed bone sarcomas in 20% (3/15) of females at 448±25 days and in 8% (1/12) of males at 523 days. After infection of newborns with Akv, an infectious retrovirus derived from the ecotropic provirus of the AKR mouse, 69% (20/28)...article 1995
- document
-
Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...article 1994
- document
-
Hirasing, R.A. (author), Reus, H. (author), TNO Preventie en Gezondheid (author)Good long-term results of dry bed training of children with nocturnal enuresis. Objective. To determine the long-term effect of dry bed training in a youth health care setting. Setting. Haarlemmermeer, the Netherlands.Design. Descriptive. Method. Parents of 36 children (mean age 9 year) subjected to dry bed training in 1987-1989, were asked in...article 1994
- document
-
van de Kar, N.C.A.J. (author), van Hinsbergh, V.W.M. (author), Brommer, E.J.P. (author), Monnens, L.A.H. (author), Gaubius Laboratory TNO Preventie en Gezondheid Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Fibrinolytic parameters and von Willebrand factor (vWF) antigen were measured in the plasma of 10 patients with hemolytic uremic syndrome (HUS). Samples were taken at presentation and again 2 wk later, before and after infusion of 1-desamino-8-arginine vasopressin. Compared with the plasma values of healthy control children, levels of tissue...article 1994
- document
-
Nijhuis, E. (author), Hinloopen, B. (author), van Duijn, C. (author), Hofman, A. (author), Rozing, J. (author), Nagelkerken, L. (author), Section of Immunology, Inst. of Aging and Vascular Research, TNO, Leiden, Netherlands TNO Preventie en Gezondheid (author)Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched controls. Since no significant differences were found...article 1994
- document
-
van Helden, H.P.M. (author), van der Wiel, H.J. (author), Zijlstra, J.J. (author), Melchers, B.P.C. (author), Busker, R.W. (author)The oximes HI-6, HLo-7, HGG-12, HGG-42 and obidoxime were used in a previously developed rat model to evaluate the therapeutic effects of oximes other than acetylcholinesterase (AChE) reactivation (so-called 'nonreactivating effects'). To test this anaesthetized, atropinized and artificially ventilated rats (n = 8 or 16) were poisoned with a...article 1994
- document
-
TNO Preventie en Gezondheid (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), van Houten, M. (author), Smit, G.P. (author), Sengers, R.C. (author)We studied the relationship between plasma phenylalanine level at first diagnostic visit, country of origin of the mother, birth cohort, child clinic, sex, and social class on the one hand and mean plasma phenylalanine levels in the first five years of life on the other hand in patients with phenylketonuria (PKU) who were treated early. The...article 1994
- document
-
Qvigstad, E. (author), Verloove-Vanhorick, S.P. (author), Ens-Dokkum, M.H. (author), Schreuder, A.M. (author), Veen, S. (author), Brand, R. (author), Oostdijk, W. (author), Ruys, J.H. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)To predict height at five years in a cohort of 565 very preterm and/or very low-birth-weight children, hypothesized growth determinants were subjected to discriminant analysis. Many neonatal parameters were not significantly associated with short stature at five years of age. A correct classification of stature (smaller/larger than the 10th...article 1993
- document
-
Banta, H.D. (author), Schersten, T. (author), Jonsson, E. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)The field of minimally invasive therapy (MIT) raises many important issues for the future of health care. It seems inevitable that MIT will replace much conventional surgery. This trend is good for society and good for patients. The health care system, however, may find the change disruptive. The need for hospital beds will shrink. Day surgery...article 1993
- document
-
TNO Biomedical Instrumentation (author), Wesseling, K.H. (author), Jansen, J.R.C. (author), Settels, J.J. (author), Schreuder, J.J. (author)We computed aortic flow pulsations from arterial pressure by simulating a nonlinear, time-varying three-element model of aortic input impedance. The model elements represent aortic characteristic impedance, arterial compliance, and systemic vascular resistance. Parameter values for the first two elements were computed from a published, age...article 1993
- document
-
Instituut CIVO-Toxicologie en Voeding TNO (author), den Besten, C. (author), van Bladeren, P.J. (author), Duizer, E. (author), Vervoort, J. (author), Rietjens, I.M.C.M. (author)In the present study the oxidative dehalogenation of a para-halogenated phenol was studied using pentafluorophenol and its non-para-halogenated analogue 2,3,5,6-tetrafluorophenol as model compounds. 19F NMR was used to characterize the metabolite patterns. In order to study the primary oxidation products of the microsomal cytochrome P450...article 1993
- document
-
Instituut CIVO-Toxicologie en Voeding TNO (author), Boyd, D.R. (author), Sharma, N.D. (author), Agarwal, R. (author), McMordie, R.A.S. (author), Bessems, J.G.M. (author), van Ommen, B. (author), van Bladeren, P.J. (author)Both 1,2-dihydronaphthalene and 1,2-dihydroanthracene were hydroxylated at the benzylic (1-) or the allylic (2-) position by rat liver microsomes and purified cytochrome P-450 enzymes to yield "arene hydrates". Two other classes of metabolites were formed, the dehydrogenation products naphthalene and anthracene, and trans-1,2-dihydroxy-1,2,3,4...article 1993
- document
-
Medisch Biologisch Laboratorium TNO (author), Verdoes, J.C. (author), Punt, P.J. (author), Schrickx, J.M. (author), van Verseveld, H.W. (author), Stouthamer, A.H. (author), van den Hondel, C.A.M.J.J. (author)A strategy, based on the usage of the amdS selection marker and a cosmid vector containing four copies of the glucoamylase gene (glaA), was developed to obtain glucoamylase (GLA)-overproducing A. niger strains. With this strategy, fungal strains carrying up to 200 copies of the glaA gene could be isolated at a relatively high frequency. In each...article 1993
- document
-
Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author), HogenEsch, H. (author), de Geus, B. (author), Tielen, F. (author), Rozing, J. (author)We investigated the expression of Ly-6.A2 on isolated murine epidermal cells by flow cytometry. Ly-6.A2 was expressed on 61% of keratinocytes and 6% of dendritic epidermal T cells of C57BL mice. Phosphatidylinositol-specific phospholipase C removed Ly-6.A2, indicating that the antigen is anchored to the keratinocyte membrane via a glycosyl...article 1993
- document
-
Zwart, A. (author), Arts, J.H.E. (author), ten Berge, W.F. (author), Appelman, L.M. (author)A new design for acute inhalation toxicity testing was evaluated and compared with results obtained according to OECD guideline 403. The new design consists of a range-finding test, which is compatible with a conventional limit test, and can be followed by determination of a concentration-time-mortality relationship, enabling calculation of LC50...article 1992
- document
-
Havenith, G. (author), van de Linde, E.J.G. (author), Heus, R. (author)Hand cooling and resulting comfort and pain were studied in 12 subjects, while touching six different materials (polyurethane foam, wood, nylon, rustproof steel, aluminium, and temperature-controlled metal) which were initially at ambient temperature. This was done for three ambient temperatures (-10°, 0° and 10°C), after pre-exposure exercise...article 1992
- document
-
Theeuwes, J. (author)Three visual-search experiments tested whether the preattentive parallel stage can selectively guide the attentive stage to a particular known-to-be-relevant target feature. Subjects searched multielement displays for a salient green circle that had a unique form when surrounded by green nontarget squares or had a unique color when surrounded by...article 1992
- document
-
van Delft, J.H.M. (author), van den Ende, A.M.C. (author), Keizer, H.J. (author), Ouwerkerk, J. (author), Baan, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author)An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration. From four patients who received dacarbazine only, at dosages of 250, 400 or 800 mg/m2, the blood samples were collected before and several days...article 1992
- document
-
Instituut voor verouderings- en vaatziekten onderzoek TNO (author), van de Kar, N.C.A.J. (author), Monnens, L.A.H. (author), Karmali, M.A. (author), van Hinsbergh, V.W.M. (author)The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an acute gastroenteritis, has been associated with a verocytotoxin-producing Escherichia coli infection. The endothelial cell is believed to play an important role in the pathogenesis of HUS. Endothelial cell damage by verocytotoxin-1 (VT-1) in vitro is potentiated by the...article 1992
- document
-
Gaubius Instituut TNO (author), Brommer, E.J.P. (author), van Potter Loon, B.J. (author), Rijken, D.C. (author), van Bockel, J.H. (author)Chemicals/CAS: Plasminogen, 9001-91-6; Streptokinase, EC 3.4.-.article 1992