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Fluitman, K.S. (author), Wijdeveld, M. (author), Davids, M. (author), van Ruiten, C.C. (author), Reinders, I. (author), Wijnhoven, H.A.H. (author), Keijser, B.J.F. (author), Visser, M. (author), Nieuwdorp, M. (author), IJzerman, R.G. (author)Expert groups argue to raise the recommended daily allowance for protein in older adults from 0.8 to 1.2 g/kg/day to prevent undernutrition. However, protein is thought to increase satiety, possibly through effects on gut microbiota and central appetite regulation. If true, raising daily protein intake may work counterproductively. In a...article 2023
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Fluitman, K.S. (author), Davids, M. (author), Olofsson, L.E. (author), Wijdeveld, M. (author), Tremaroli, V. (author), Keijser, B.J.F. (author), Visser, M. (author), Bäckhed, F. (author), Nieuwdorp, M. (author), IJzerman, R.G. (author)Background: Older adults are particularly prone to the development of poor appetite and undernutrition. Possibly, this is partly due to the aged gut microbiota. We aimed to evaluate the gut microbiota in relation to both poor appetite and undernutrition in community-dwelling older adults. Furthermore, we studied the causal effects of the...article 2022
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Fluitman, K.S. (author), Hesp, A.C. (author), Kaihatu, R.F. (author), Nieuwdorp, M. (author), Keijser, B.J.F. (author), IJzerman, R.G. (author), Visser, M. (author)BACKGROUND: Age-related declines in taste and smell function are widely assumed to contribute to the decrease in appetite and the development of undernutrition in older adults. OBJECTIVES: Here we aim to assess the associations of both taste and smell function with several nutrition-related outcomes in a single study, with poor appetite and...article 2021
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Fluitman, K.S. (author), van den Broek, T.J. (author), Nieuwdorp, M. (author), Visser, M. (author), IJzerman, R.G. (author), Keijser, B.J.F. (author)Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric...article 2021
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Bellmann, S. (author), Krishnan, S. (author), de Graaf, A. (author), de Ligt, R.A. (author), Pasman, W.J. (author), Minekus, M. (author), Havenaar, R. (author)The expected increase of global obesity prevalence makes it necessary to have information about the effects of meal intakes on the feeling of appetite. Because human clinical studies are time and cost intensive, there is a need for a reliable alternative. The aim of this study was to develop and evaluate an in vitro-in silico technology to...article 2019
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Toet, A. (author), van Schaik, M.G. (author), Kaneko, D. (author), Erp. J.B.F. van, (author)Viewing images of food triggers the desire to eat and this effect increases when images represent food in a more vivid way. Cinemagraphs are a new medium that is intermediate between photographs and videos: most of the frame is static, while some details are animated in a seamless loop, resulting in a vivid viewing experience. On social media...article 2019
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Fluitman, K.S. (author), Nadar, H.J. (author), Roos, D.S. (author), Berendse, H.W. (author), Keijser, B.J.F. (author), Nieuwdorp, M. (author), Ijzerman, R.G. (author), Visser, M. (author)Objectives: The olfactory decline that often accompanies aging is thought to contribute to undernutrition in older adults. It is believed to negatively affect eating pleasure, appetite, food intake and subsequently nutritional status. We have evaluated the associations of olfactory function with BMI, appetite and prospective weight change in a...article 2019
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Pasman, W.J. (author), Hendriks, H.F.J. (author), Minekus, M.M. (author), de Ligt, R.A.F. (author), Scholtes-Timmerman, M.J. (author), Clabbers, N.D.S. (author), Leonards, N.M. (author), Johnson, J. (author), Bellmann, S. (author)Background: Appetite regulating properties of foods are usually investigated under laboratory conditions, whereas in real life, foods are consumed under at home conditions. The objective of this study was to compare the acute effects of breakfasts when tested in a laboratory condition and in an at home condition. Appetite regulating properties...article 2018
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Ibarra, A. (author), Olli, K. (author), Pasman, W. (author), Hendriks, H. (author), Alhoniemi, E. (author), Raza, G.S. (author), Herzig, K.H. (author), Tiihonen, K. (author)Polydextrose (PDX) reduces subsequent energy intake (EI) when administered at midmorning in single-blind trials of primarily normal-weight men. However, it is unclear if this effect also occurs when PDX is given at breakfast time. Furthermore, for ecological validity, it is desirable to study a female population, including those at risk for...article 2017
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Toet, A. (author), van Schaik, M.G. (author), van Erp, J.B.F. (author), Kaneko, D. (author)Cinemagraphs are a new medium that is intermediate between photographs and videos: most of the frame is static, while some details are animated in a seamless loop. Given their vivid appearance we expected that food cinemagraphs evoke stronger affective and appetitive responses than their static counterparts (stills). In this study we measured...conference paper 2017
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TNO Voeding (author), Eelderink, C. (author), Noort, M.W.J. (author), Sozer, N. (author), Koehorst, M. (author), Holst, J.J. (author), Deacon, C.F. (author), Rehfeld, J.F. (author), Poutanen, K. (author), Vonk, R.J. (author), Oudhuis, L. (author), Priebe, M.G. (author)Purpose: Underlying mechanisms of the beneficial health effects of low glycemic index starchy foods are not fully elucidated yet. We varied the wheat particle size to obtain fiber-rich breads with a high and low glycemic response and investigated the differences in postprandial glucose kinetics and metabolic response after their consumption....article 2017
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Schrieks, I.C. (author), Stafleu, A. (author), Griffioen-Roose, S. (author), de Graaf, C. (author), Witkamp, R.F. (author), Boerrigter-Rijneveld, R. (author), Hendriks, H.F.J. (author)The aim of this study was to investigate whether food reward plays a role in the stimulating effect of moderate alcohol consumption on subsequent food intake. In addition, we explored the role of oral and gut sensory pathways in alcohol's effect on food reward by modified sham feeding (MSF) or consumption of a preload after alcohol intake.In a...article 2015
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Vernooij-van Langen, A.M.M. (author), van der Pal, S.M. (author), Reijntjens, A.J.T. (author), Loeber, J.G. (author), Dompeling, E. (author), Dankert-Roelse, J.E. (author)Background: False-positive screening results in newborn screening for cystic fibrosis may lead to parental stress, family relationship problems and a changed perception of the child's health. Aim of the study: To evaluate whether parental anxiety induced by a false positive screening result disappears after six months and to assess whether a...article 2014
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Boon, M.R. (author), Kooijman, S. (author), van Dam, A.D. (author), Pelgrom, L.R. (author), Berbée, J.F.P. (author), Visseren, C.A.R. (author), van Aggele, R.C. (author), van den Hoek, A.M. (author), Sips, H.C.M. (author), Lombès, M. (author), Havekes, L.M. (author), Tamsma, J.T. (author), Guigas, B. (author), Meijer, O.C. (author), Jukema, J.W. (author), Rensen, P.C.N. (author)The endocannabinoid system is an important player in energy metabolism by regulating appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (CB1R) leads to long-term maintenance of weight loss and reduction of dyslipidemia in experimental and human obesity. The molecular mechanism by which CB1R blockade...article 2014
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TNO Kwaliteit van Leven (author), Pasman, W.J. (author), Heimerikx, J. (author), Rubingh, C.M. (author), van den Berg, R. (author), O'Shea, M. (author), Gambelli, L. (author), Hendriks, H.F.J. (author), Einerhand, A.W.C. (author), Scott, C. (author), Keizer, H.G. (author), Mennen, L.I. (author)Appetite suppressants may be one strategy in the fight against obesity. This study evaluated whether Korean pine nut free fatty acids (FFA) and triglycerides (TG) work as an appetite suppressant. Korean pine nut FFA were evaluated in STC-1 cell culture for their ability to increase cholecystokinin (CCK-8) secretion vs. several other dietary...article 2008
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Fekkes, M. (author), Pijpers, F.I.M. (author), Fredriks, A.M. (author), Vogels, T. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)OBJECTIVES. A number of studies have shown that victimization from bullying behavior is associated with substantial adverse effects on physical and psychological health, but it is unclear which comes first, the victimization or the health-related symptoms. In our present study, we investigated whether victimization precedes psychosomatic and...article 2006
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Smeets, P.A.M. (author), de Graaf, C. (author), Stafleu, A. (author), van Osch, M.J.P. (author), Nievelstein, R.A.J. (author), van der Grond, J. (author), TNO Kwaliteit van Leven (author)Background: The brain plays a crucial role in the decision to eat, integrating multiple hormonal and neural signals. A key factor controlling food intake is selective satiety, ie, the phenomenon that the motivation to eat more of a food decreases more than does the motivation to eat foods not eaten. Objective: We investigated the effect of...article 2006
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Weenen, H. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)The time dependence of the liking of foodstuffs was investigated in a study with 25 subjects, consisting of three parts: (1) on day one, a sensory specific satiety study, which was extended until 125 min after consumption; (2) on days two to seven, a repeated in home taste and evaluation study; (3) on day eight, a second sensory specific satiety...article 2005
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Blom, W.A.M. (author), Stafleu, A. (author), de Graaf, C. (author), Kok, F.J. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)Background: Ghrelin plays an important role in the regulation of food intake. Little is known about how ghrelin concentrations are modified by dietary factors. Objective: We examined the effects of both amount and type of carbohydrate on ghrelin concentrations and all correlations among the variables ghrelin, glucose, insulin, leptin, and all 4...article 2005
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Snoek, H.M. (author), Huntjens, L. (author), van Gemert, L.J. (author), de Graaf, C. (author), Weenen, H. (author), TNO Voeding (author)Background: Sensory-specific satiety has been found to play an important role in food choice and meal termination, and it might be a factor contributing to obesity. Objective: We hypothesized that obese and normal-weight people have different sensitivities to sensory-specific satiety for high-fat foods. Design: Sensory-specific satiety was...article 2004
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