Searched for: subject%3A%22Aorta%22
(41 - 57 of 57)

Pages

document
de Winther, M.P.J. (author), Gijbels, M.J.J. (author), van Dijk, K.W. (author), van Gorp, P.J.J. (author), Suzuki, H. (author), Kodama, T. (author), Frants, R.R. (author), Havekes, L.M. (author), Hofker, M.H. (author), Gaubius instituut TNO (author)
Apolipoprotein (apo) E3Leiden is a dysfunctional apo E variant associated with familial dysbetalipoproteinemia in humans. Transgenic mice carrying the APOE3Leiden gene develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. An early step in atherosclerosis is foam cell formation, which is thought to result from the...
article 1999
document
Stergiopulos, N. (author), Westerhof, B.E. (author), Westerhof, N. (author), TNO Biomedical Instrumentation (author)
We propose a new method to derive aortic pressure from peripheral pressure and velocity by using a time domain approach. Peripheral pressure is separated into its forward and backward components, and these components are then shifted with a delay time, which is the ratio of wave speed and distance, and added again to reconstruct aortic pressure....
article 1998
document
Leppänen, P. (author), Luoma, J.S. (author), Hofker, M.H. (author), Havekes, L.M. (author), Ylä-Herttuala, S. (author), Gaubius Instituut TNO (author)
Apo E3-leiden transgenic mice express human dysfunctional apo E variant and develop hyperlipidemia and atherosclerosis on a high fat/high cholesterol diet. We characterized diet-induced atherosclerotic lesions in apo E3-leiden transgenic mice using immunocytochemical methods in order to examine foam cell formation and determine whether advanced...
article 1998
document
Blum, V. (author), Carrière, E.G.J. (author), Kolsters, W. (author), Mosterd, W.L. (author), Schiereck, P. (author), Wesseling, K.H. (author), TNO Biomedical Instrumentation (author)
The purpose of this study was to compare aortic blood pressure (AOR) to peripheral measurements by the Riva-Rocci/Korotkov (RRK) and Finapres continuous finger pressure (FIN) methods during dynamic and static exercise. A tip manometer was introduced in the ascending aorta after coronary angiography in 7 cardiac patients with good exercise...
article 1997
document
Groot, P.H.E. (author), van Vlijmen, B.J.M. (author), Benson, G.M. (author), Hofker, M.H. (author), Schiffelers, R. (author), Vidgeon-Hart, M. (author), Havekes, L.M. (author), Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Frythe, Welwyn, Hertfordshire, United Kingdom TNO-Prevention and Health, Gaubius Laboratory, Leiden, Netherlands SmithKline Beecham Pharmaceuticals, Frythe, Welwyn (Herts), AL6 9AR, United Kingdom TNO Preventie en Gezondheid (author)
Transgenic mice overexpressing the human dysfunctional apolipoprotein E variant, APOE*3 Leiden, develop hyperlipidemia and are highly susceptible to diet-induced atherosclerosis. In the present study, we investigated the effects of diet composition and feeding period on serum cholesterol exposure and the amount of atherosclerosis in the aortic...
article 1996
document
van Leeuwen, R.T.J. (author), Quax, P.H.A. (author), Tippins, J.R. (author), Antoniw, J.W. (author), Andreotti, F. (author), Maseri, A. (author), Kluft, C. (author), Sperti, G. (author), Gaubius Instituut TNO (author)
Background: Lipopolysaccharide (endotoxin) has been shown to increase the expression of plasminogen activator inhibitor type-1 (PAI-1) in the vessel wall. Endotoxin is known to increase PAI-1 production in endothelial cells, but its action on smooth muscle cells (SMCs) is presently not clear. In this study we determined the effect of endotoxin...
article 1996
document
Draijer, R. (author), Atsma, D.E. (author), van der Laarse, A. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the endothelial permeability is increased by thrombin. In this study, we have investigated the mechanism by which cGMP improves the endothelial barrier function and examined whether nitric oxide (NO) can serve as an...
article 1995
document
van Ree, J.H. (author), van den Broek, W.J.A.A. (author), Dahlmans, V.E.H. (author), Wieringa, B. (author), Frants, R.R. (author), Havekes, L.M. (author), Hofker, M.H. (author), TNO Preventie en Gezondheid (author)
Chemicals/CAS: Apolipoproteins E; Cholesterol, 57-88-5
article 1995
document
Draijer, R. (author), Vaandrager, A.B. (author), Nolte, C. (author), de Jonge, H.R. (author), Walter, U. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Previous studies demonstrated that the thrombin-induced permeability of endothelial cell monolayers is reduced by the elevation of cGMP. In the present study, the presence of cGMP-dependent protein kinase (cGMP-PK) immunoreactivity and activity in various types of human endothelial cells (ECs) and the role of cGMP-PK in the reduction of thrombin...
article 1995
document
Padro, T. (author), Quax, P.H.A. (author), van den Hoogen, C.M. (author), Roholl, P. (author), Verheijen, J.H. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Plasminogen activator (PA) and PA inhibitor (PAI) antigen, activity, and mRNA were analyzed in the three layers of rat aorta, and the effect of endotoxin on PA and PAI was studied. All PA activity in aorta was identified as tissue-type PA (TPA) activity; no urokinase-type PA was detected. In the tunica adventitia TPA activity, TPA antigen, and...
article 1994
document
van Leeuwen, R.T.J. (author), Kol, A. (author), Andreotti, F. (author), Kluft, C. (author), Maseri, A. (author), Sperti, G. (author), Gaubius Instituut TNO (author)
Background: The role of angiotensin as a vasoconstrictor is well established. Lately, several other actions of this hormone on vascular smooth muscle (VSM) cells have been recognized including the induction of hypertrophy and/or DNA synthesis. Platelet-derived growth factor (PDGF), a mitogen recently shown to increase plasminogen activator...
article 1994
document
van Ree, J.H. (author), van den Broek, W.J.A.A. (author), Dahlmans, V.E.H. (author), Groot, P.H.E. (author), Vidgeon-Hart, M. (author), Frants, R.R. (author), Wieringa, B. (author), Havekes, L.M. (author), Hofker, M.H. (author), TNO Preventie en Gezondheid (author)
Apolipoprotein (apo) E is a ligand for the receptor-mediated uptake of lipoprotein remnant particles. Complete absence of apo E in humans leads to a severe form of type III hyperlipoproteinemia. We have used targeted inactivation in murine embryonic stem cells, as also described by others, to specifically study the effects of heterozygous Apoe...
article 1994
document
TNO Biomedical Instrumentation (author), Wesseling, K.H. (author), Jansen, J.R.C. (author), Settels, J.J. (author), Schreuder, J.J. (author)
We computed aortic flow pulsations from arterial pressure by simulating a nonlinear, time-varying three-element model of aortic input impedance. The model elements represent aortic characteristic impedance, arterial compliance, and systemic vascular resistance. Parameter values for the first two elements were computed from a published, age...
article 1993
document
Atsma, D.E. (author), Feitsma, R.I.J. (author), Camps, J. (author), van 't Hooft, F.M. (author), van der Wall, E.E. (author), Nieuwenhuizen, W. (author), Pauwels, E.K.J. (author), Gaubius Laboratory Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
In this study we evaluated two different 99mTc-labeling techniques to produce 99mTc-low density lipoprotein (99mTc-LDL) suitable for the scintigraphic delineation of experimental atherosclerotic lesions. The two methods are 1) a procedure that uses stannous chloride and sodium borohydride (borohydride method) and 2) a procedure that uses sodium...
article 1993
document
Gaubius Instituut TNO (author), Brommer, E.J.P. (author), van Potter Loon, B.J. (author), Rijken, D.C. (author), van Bockel, J.H. (author)
Chemicals/CAS: Plasminogen, 9001-91-6; Streptokinase, EC 3.4.-.
article 1992
document
Guinan, M.E. (author), Astrup, T. (author), Gaubius instituut TNO (author)
The arteries of the rat usually possess considerably higher endothelium-related fibrinolytic activity than corresponding veins. This finding contrasts observations in most other species, including man. The use of the rat in experimental work on thrombotic vascular disease should be evaluated with due regard to the specific properties of the...
article 1980
document
Hollander, C.F. (author), Instituut voor experimentele gerontologie TNO (author), GO RBI IVEG (author)
Cartilaginous tissue in the heart of rat has been described in literature by some as an ageing phenomenon, while others have observed it in young animals. Hearts of rats of different ages were studied for the occurence and localization of cartilaginous tissue. A cartilaginous focus has been regularly found in rats as young as 1 week old. This...
article 1968
Searched for: subject%3A%22Aorta%22
(41 - 57 of 57)

Pages