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Wark, P.A. (author), Weijenberg, M.P. (author), van 't Veer, P. (author), van Wijhe, G. (author), Luchtenborg, M. (author), van Muijen, G.N.P. (author), de Goeij, A.F.P.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: Clinical and pathologic differences exist between colon carcinomas deficient and proficient in the mismatch repair protein hMLH1. Animal and in vitro studies suggest that fruits, vegetables, folate, and antioxidants are associated with colonic expression of mismatch repair genes. Methods: Associations between consumption of fruits...article 2005
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Ullmann, U. (author), Haller, J. (author), Bakker, G.C.M. (author), Brink, E.J. (author), Weber, P. (author), TNO Kwaliteit van Leven (author)A number of studies have shown that tea catechins can inhibit intestinal iron absorption, mostly iron in the nonhaem form. This randomized, double-blind, placebo-controlled, 3-periods cross-over study examined the degree of inhibition of nonhaem iron absorption by pure crystalline epigallocatechin gallate (EGCG). The study was designed to show...article 2005
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Post, S.M. (author), Groenendijk, M. (author), Solaas, K. (author), Rensen, P.C.N. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)Objective-Cholesterol 7α-hydroxylase (cyp7a1) catalyzes the rate-limiting step in conversion of cholesterol to bile acids. To study the relationship between bile acid biosynthesis and triglyceride metabolism, we cross-bred mice lacking cyp7a1 on a hyperlipidemic APOE*3-Leiden background. Methods and Results-Female mice received a chow or...article 2004
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Price, R.J. (author), Scott, M.P. (author), Walters, D.G. (author), Stierum, R.H. (author), Groten, J.P. (author), Meredith, C. (author), Lake, B.G. (author), TNO Voeding (author)The effect of thiabendazole (TB) on some rat hepatic xenobiotic metabolising enzymes has been investigated. Male Sprague-Dawley rats were fed control diet or diets containing 102-5188 ppm TB for 28 days. As a positive control for induction of hepatic xenobiotic metabolism, rats were also fed diets containing 1457 and 10,155 ppm butylated...article 2004
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Krul, C.A.M. (author), Zeilmaker, M.J. (author), Schothorst, R.C. (author), Havenaar, R. (author), TNO Voeding (author)Human exposure to carcinogenic N-alkylnitrosamines can occur exogenously via food consumption or endogenously by formation of these compounds through nitrosation of amine precursors. Information on the intragastric formation of NDMA from complex mixtures of precursors and inhibitors in humans is not available. In this study the formation of N...article 2004
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TNO Preventie en Gezondheid (author), Jukema, J.W. (author), van der Hoorn, J.W.A. (author)Hypertension and hyperlipidaemia are major risk factors for the development of atherosclerosis. Calcium channel blockers (CCBs) have been used for decades and have established antihypertensive effects. Statins have been extensively used because of their potent lipid lowering properties. Amongst other factors, inflammation and oxidation are...article 2004
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Dommels, Y.E.M. (author), Haring, M.M.G. (author), Keestra, N.G.M. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)This study was conducted to investigate the role of the enzyme cyclooxygenase (COX) and its prostaglandin product PGE2 in n-6 and n-3 polyunsaturated fatty acid (PUFA)-mediated effects on cellular proliferation of two human colorectal carcinoma cell lines. The long chain PUFAs eicosapentaenoic acid (EPA; 20:5n-3) and arachidonic acid (AA; 20:4n...article 2003
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Jonker, D. (author), Kuper, C.F. (author), Fraile, N. (author), Estrella, A. (author), Rodríguez Otero, C. (author), TNO Voeding (author)Lycopene, as a suspension in sunflower oil (20% w/w), was tested for subchronic toxicity by administration at dietary concentrations of 0, 0.25, 0.50, and 1.0% to groups of 20 male and 20 female Wistar rats for a period of 90 days. The lycopene examined in this study was derived from a fungal biomass (Blakeslea trispora). Lycopene intake was...article 2003
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Hoppe, P.P. (author), Krämer, K. (author), van den Berg, H. (author), Steenge, G. (author), van Vliet, T. (author), TNO Voeding (author)Background: Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. Aim of the study: To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel trial. Methods: Three...article 2003
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Rhodes, L.E. (author), Shahbakhti, H. (author), Azurdia, R.M. (author), Moison, R.M.W. (author), Steenwinkel, M.J.S.T. (author), Homburg, M.I. (author), Dean, M.P. (author), McArdle, F. (author), Beijersbergen van Henegouwen, G.M.J. (author), Epe, B. (author), Vink, A.A. (author)Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) protect against photocarcinogenesis in animals, but prospective human studies are scarce. The mechanism(s) underlying the photoprotection are uncertain, although ω-3 PUFAs may influence oxidative stress. We examined the effect of supplementation on a range of indicators of ultraviolet...article 2003
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van den Brandt, P.A. (author), Zeegers, M.P.A. (author), Bode, P. (author), Goldbohm, R.A. (author)Results of a randomized controlled trial have suggested a protective effect of selenium against prostate cancer. Few other prospective studies have been conducted to confirm or refute this. The association between prostate cancer and baseline toenail selenium level was evaluated in the Netherlands Cohort Study, conducted among 58,279 men, aged...article 2003
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TNO Voeding (author), Awad, H.M. (author), Boersma, M.G. (author), Boeren, S. (author), van Bladeren, P.J. (author), Vervoort, J. (author), Rietjens, I.M.C.M. (author)Oxidation of flavonoids with a catechol structural motif in their B ring leads to formation of flavonoid quinone/quinone methides, which rapidly react with GSH to give reversible glutathionyl flavonoid adducts. Results of the present study demonstrate that as a thiol-scavenging agent for this reaction Cys is preferred over GSH and N...article 2003
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- Stahl, W. (author), van den Berg, H. (author), Arthur, J. (author), Bast, A. (author), Dainty, J. (author), Faulks, R.M. (author), Gärtner, C. (author), Haenen, G. (author), Hollman, P. (author), Holst, B. (author), Kelly, F.J. (author), Cristina Polidori, M. (author), Rice-Evans, C. (author), Southon, S. (author), van Vliet, T. (author), Viña-Ribes, J. (author), Williamson, G. (author), Astley, S.B. (author) article 2002
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Gómez-Aracena, J. (author), Martin-Moreno, J.M. (author), Riemersma, R.A. (author), Bode, P. (author), Gutiérrez-Bedmar, M. (author), Gorgojo, L. (author), Kark, J.D. (author), Garcia-Rodríguez, A. (author), Gomez-Gracia, E. (author), Kardinaal, A.F.M. (author), Aro, A. (author), van 't Veer, P. (author), Wedel, H. (author), Kok, F.J. (author), Fernández-Crehuet, J. (author)The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 μg/kg in cases and 7.75 μg/kg in...article 2002
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Schuurman, A.G. (author), Goldbohm, R.A. (author), Brants, H.A.M. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objectives: The roles of retinol, vitamins C and E, and carotenoids as risk factors for prostate carcinoma are still questionable. We evaluated these in the Netherlands Cohort Study. Methods: The cohort study consisted of 58,279 men ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 642 incident prostate carcinoma cases were...article 2002
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Gierus, M. (author), Schwarz, F.J. (author), Kirchgessner, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In three separate trial series (TS) the effect of diet composition on selenium (Se) status of dairy cows were investigated. Diets were formulated based mainly on grass (TS1), grass silage (TS2) or maize silage (TS3) with different levels of Se supplementation. Each TS comprised a total of 30 dairy cows and contained one treatment group without...article 2002
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Helmroth, I.E. (author), Dekker, M. (author), Hankemeier, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The effect of solvent absorption on additive migration was studied by relating the diffusion coefficient (D) of Irganox 1076 to the maximum solvent absorption of different solvents in low-density polyethylene (LDPE) film. Solvents tested were ethanol, isopropanol, isooctane, ethylacetate, cyclohexane, tributyrin, tricaprylin and olive oil....article 2002
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van den Berg, R. (author), van Vliet, T. (author), Broekmans, W.M.R. (author), Cnubben, N.H.P. (author), Vaes, W.H.J. (author), Roza, L. (author), Haenen, G.R.M.M. (author), Bast, A. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The potential benefits of a high fruit and vegetable intake on the antioxidant status and on relevant biomarkers of oxidative damage to lipids, proteins and DNA and on (functional) markers of oxidative stress were evaluated. A randomized, free living, open placebo-controlled cross-over trial of 3 wk, with a 2-wk washout period between treatments...article 2001
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Diplock, A.T. (author), van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: Antioxidants; Vitaminsarticle 2001
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Cnubben, N.H.P. (author), Rietjens, I.M.C.M. (author), Wortelboer, H. (author), van Zanden, J.J. (author), van Bladeren, P.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH itself is a critical factor in maintaining the cellular redox balance and has been demonstrated to be involved in regulation of cell signalling and repair pathways. Enhanced expression of...article 2001