Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice

The circadian clock, shift work, and tissue-specific insulin resistance

Anti-PCSK9 antibodies inhibit pro-atherogenic mechanisms in APOE*3Leiden.CETP mice

The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST

Systems approach for classifying the response to biological therapies in patients with rheumatoid arthritis in clinical practice

Purification and Characterization of Naturally Occurring Post-Translationally Cleaved Ara h 6 an Allergen That Contributes Substantially to the Allergenic Potency of Peanut

Food processing and allergenicity

A fungal biofilm reactor based on metal structured packing improves the quality of a Gla::GFP fusion protein produced by Aspergillus oryzae

The ultimate radiochemical nightmare: Upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia

The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab

Toll-like receptor 2 activation by β2→1-fructans protects barrier function of t84 human intestinal epithelial cells in a chain length-dependent manner

Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry: Morphology selective binding of Fabs to hepatitis B virus capsids

PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE

The Göttingen minipig® as an alternative non-rodent species for immunogenicity testing: A demonstrator study using the IL-1 receptor antagonist anakinra

Bioanalytical LC-MS/MS of protein-based biopharmaceuticals

Is the tiered immunogenicity testing of biologics the adequate approach in preclinical development?

Exploring an orbitrap analyzer for the characterization of intact antibodies by native mass spectrometry

αB-crystallin is a target for adaptive immune responses and a trigger of innate responses in preactive multiple sclerosis lesions

Developmental immunotoxicity of methylmercury: The relative sensitivity of developmental and immune parameters