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Stevens, W.F. (author), Slaaf, D.W. (author), Hooisma, J. (author), Magchielse, T. (author), Meeter, E. (author), Medisch Biologisch Laboratorium TNO (author)A less complicated source of neurons suitable for this type of studies is the parasympathetic ciliary ganglion. In the pigeon and in the chick this ganglion is known to contain only two classes of neurons, both of which are cholinoceptive and cholinergic and that innervate the muscle fibres of the choroid plexus of the eye, the sphincter iridis...article 1978
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van der Waaij, D. (author), Tieleman-Speltie, T.M. (author), Roeck de - Houben, A.M.J. (author), Radiobiologisch Instituut TNO (author)Lethally irradiated conventional mice were killed at daily intervals after irradiation. A high correlation was found between the occurrence of bacterial over-growth in the digestive tract and invasion into the regional lymph nodes the spleen and the blood. By oral contamination of mice with quite high doses of either an exogenous or an...article 1978
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Widmer, M.B. (author), Balner, H. (author), Primatencentrum TNO (author)The genetic basis for MLC reactivity in rhesus monkeys was further investigated. Cells from an intra-RhLA recombinant monkey were MLC reactive with those of an SD-identical sib and with each of two sets of homozygous typing cells carrying either paternal haplotype. Also, cells from a pair of RhLA- identical sibs reacted in MLC with each other,...article 1978
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Kilbey, B.J. (author), Igali, S. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)A statement of general principles and minimal criteria for the screening of chemicals for potential mutagenicity in man that may be used as guidelines for regulatory agencies and industrial organisations. To make clear the potentialities and current limitations of short-term mutagenicity testing for the prediction of genetic and carcinogenic...article 1978
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Wolthuis, O.L. (author), Kepner, L.A. (author), Medisch Biologisch Laboratorium TNO (author)The bisquarternary mono-oxime HI-6, and to a lesser extent HS-6, caused functional recovery of neuromuscular transmission in vivo and in vitro when given 60 min after soman, i.e. when the soman-cholinesterase (AChE) complex is said to be fully 'aged'. Atropinised rats, with the tracheas intubated, received 4 x LD50 soman i.v. and were kept alive...article 1978
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de Mik, G. (author), de Groot, I. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: ozone, 10028-15-6; Aerosols; Cyclohexanes; DNA, Bacterial; Ozone, 10028-15-6article 1978
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Gaubius instituut TNO (author), van Ruijven-Vermeer, I.A.M. (author), Nieuwenhuizen, W. (author)Rat fibrinogen was purified from rat plasma by using lysine-Sepharose chromatography, repeated precipitation with 25%-satd. (HN4)2SO4 and gel chromatography on Sepharose 6B. To minimize proteolytic activity, rats were injected intravenously with Trasylol before bleeding and the collected blood was treated with Trasylol and di-isopropyl...article 1978
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Kepner, L.A. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of HS-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer 'delayed deaths' were seen...article 1978
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Creemers, P. (author), Ouwehand, J. (author), Bentveizen, P. (author), Radiobiologisch Instituut TNO (author)The vaccines used in this study were derived from purified murine mammary tumor virus (MuMTV) preparations. Approximately 60% of the protein fractions consisted of the major viral membrane glycoprotein gp52. Inoculation sc of 10 pg MuMTV-S-derived vaccine significantly delayed the appearance of primary mammary tumors in GR and BALB/cfC3H mice ...article 1978
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Gaubius instituut TNO (author), van Ruijven-Vermeer, I.A.M. (author), Nieuwenhuizen, W. (author), Nooijen, W.J. (author)The authors studied the binding of Ca to rat fibrinogen and plasmic fibrin(ogen) degradation products by means of equilibrium dialysis with special reference to the protective effect of Ca2+ in the plasmic degradation of fibrinogen. Direct binding studies demonstrate that rat fibrinogen and the plasmic degradation products D(cate) and D-dimer...article 1978
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Radiobiologisch Instituut TNO (author), van Putten, L.M. (author), Smink, T. (author)Chemicals/CAS: misonidazole, 13551-87-6; Nitroimidazoles; Radiation-Sensitizing Agentsarticle 1978
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Radiobiologisch Instituut TNO (author), Maat, B. (author)Recent data on extrapulmonary colony formation after heparin administration are inconclusive. A systemic study of this topic was undertaken with 4 experimental tumour systems and 2 distinct periods of reduced clotting capacity in rats and mice. I.v. injection of various numbers of tumour cells into i.p. heparinized animals leads to: Significant...article 1978
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Kruysse, A. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)The inhalation toxicity of peroxyacetyl nitrate (PAN) was examined in acute (single exposure), subacute (4-wk repeated exposure) and subchronic (13-wk repeated exposure) studies in rats. The 4-hr LC50 was found to be 95 ppm. In the 4-wk study rats were exposed to 0, 0.9, 4.1 or 11.8 ppm PAN vapor for 6 hr/day, 5 days/wk. Exposure to 11.8 ppm...article 1977
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van der Waaij, D. (author), Vossen, J.M. (author), Korthals Altes, C. (author), Hartgrink, C. (author), Radiobiologisch Instituut TNO (author)Antibiotic decontamination of the digestive tract can suppress or eliminate all microorganisms in this tract that are sensitive to the antibiotics used for decontamination. Experimental work in animals has indicated that colonization resistance (CR) decreases to extremely low values during decontamination as a result of the suppression of the...article 1977
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van Velsen, F.L. (author), Nickolson, V.J. (author), Medisch Biologisch Laboratorium TNO Medisch Fysisch Instituut TNO (author)The effects of the myotonic agent, 9-anthroic acid (ANCA), and the acetylcholinesterase (AChE) inhibitor, soman, on the isolated phrenic nerve-diaphragm preparation of the rat were studied. ANCA induced after-contractions which followed the twitches evoked by either direct or indirect stimulation. In the intermittently stimulated muscle the...article 1977
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Polak, R.L. (author), Molenaar, P.C. (author), van Gelder, M. (author), Medisch Biologisch Laboratorium RVO-TNO (author)The uptake of [14C]choline was studied in cortical slices from rat brain after their incubation in a Krebs-Henseleit medium containing either 4.7 mM-KCl (low K), 25 mM-KCl (high K) or 25 mM-KCl without calcium (Ca free, high K). With 0.84 μM-[14C]choline in the medium the uptake per gram of tissue was 0.62 nmol after incubation in low K medium,...article 1977
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Haaijman, J.J. (author), Brinkhof, J. (author), Instituut voor Experimentele Gerontologie TNO (author), IVEG (author)The IgG fractions of rabbit antisera specific for the Fc part of mouse IgA, IgM, and the four subclasses of IgG (1, 2a, 2b, and 3) were coupled covalently to Sepharose beads by the cyanogen bromide method. The beads were then incubated with different dilutions of mouse serum. The mouse immunoglobulins (Ig) binding to the beads were demonstrated...article 1977
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Instituut voor experimentele gerontologie TNO (author), Knook, D.L. (author), Blansjaar, N. (author), Sleyster, E.C. (author)Non-parenchymal cell suspensions were prepared from rat livers by three different methods based on a collagenase, a pronase and a combined collagenase-pronase treatment. The highest yield of Kupffer and endothelial cells was obtained with the pronase treatment. Attempts were made for a further purification of these cells by Metrizamide density...article 1977
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Knook, D.L. (author), Instituut voor experimentele gerontologie TNO (author)Highly purified suspensions of parenchymal, endothelial and Kupffer cells were prepared from the rat liver. The respective roles of these cell classes in the degradation of proteins was investigated by analysing the cellular distribution of two lysomal proteases. The specific arginine naphthylamidase activity was 2 times higher in Kupffer cells...article 1977
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- Instituut voor Visserijprodukten TNO (author), van Spreekens, K.J.A. (author) article 1977