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Nickolson, V.J. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)The effect of Piracetam on rat cerebral protein metabolism in vivo and in vitro was studied. It was found that the drug stimulates the uptake of labelled leucine by cerebral cortex slices, has no effect on the incorporation of leucine into cerebral protein, neither in slices nor in vivo, but inhibits the breakdown of newly formed protein in...article 1976
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Vos, O. (author), Grant, G.A. (author), Budke, L. (author), Medisch Biologisch Laboratorium RVO-TNO (author)The effect of diamide on the radiosensitivity of T cells was investigated under oxic and anoxic conditions. The compound was found to sensitize the cells under both conditions. Under oxic conditions, exposure for 10 min before and during irradiation to 0.1, 0.5 and 1.0 mM diamide produced dose modifying factors of 0.81, 0.60 and 0.55,...article 1976
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Wolthuis, O.L. (author), de Wied, D. (author), Medisch Biologisch Laboratorium TNO Chemisch Laboratorium TNO (author)Averaged visual evoked responses (VER) in cortical area 17 were recorded one hour after the administration of 7-l-phe ACTH(4-10) or 7-d-phe ACTH(4-10) to artificially ventilated rats, paralysed with gallamine. In addition, the effects of these peptides on spontaneous motor behavior were analyzed. The results show that the latencies of all VER...article 1976
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van Putten, L.M. (author), Kram, L.K.J. (author), van Dierendonck, H.H.C. (author), Radiobiologisch Instituut TNO (author)In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and...article 1975
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Broerse, J.J. (author), Radiobiologisch Instituut TNO (author)Values of the relative biological effectiveness (RBE) of fast neutrons for effect on normal tissue depend not only on the neutron energy and the dose, but also on the type of tissue irradiated. Values of the RBE of 15 MeV neutrons are reviewed for rapidly proliferating rodent tissue, such as mouse bone marrow, mouse intestine and rat skin...article 1974
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Polak, R.L. (author), Molenaar, P.C. (author), Medisch Biologisch Laboratorium TNO (author)Demethylation by sodium benzenethiolate has been used to analyse mixtures of isotopic variants of acetylcholine (ACh) by gas chromatography/mass spectrometry (GC/MS). The present experiments show that demethylation by pyrolysis is also suitable for the simultaneous determination of deuterium labelled variants of ACh by means of GC/MS. However,...article 1974
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van Beek, L. (author), Feron, V.J. (author), de Groot, A.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Alkali treated spun soy isolate was fed to rats at dietary levels of 5, 10, and 20% for a period of 90 days. The results failed to reveal any adverse effects on general appearance, growth, feeding efficiency, hematological indices, blood serum values, urine composition, kidney function, organ weights, and gross and microscopic pathology except...article 1974
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- Padmos, P. (author) other 1974
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Radiobiologisch Instituut TNO (author), Sindram, P.J. (author), Snow, G.B. (author), van Putten, L.M. (author)Chemicals/CAS: folinate calcium, 1492-18-8, 51057-63-7; folinic acid, 58-05-9, 68538-85-2; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Leucovorin, 58-05-9; Methotrexate, 59-05-2article 1974
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Centraal Instituut voor Voedingsonderzoek TNO (author), Leegwater, D.C. (author), de Groot, A.P. (author), van Kalmthout Kuyper, M. (author)The effect of hydroxypropyl starches (degree of substitution (DS) 0.025-0.106), lactose, raw potato starch, polyethylene glycol 1000 or magnesium sulphate on caecal size and some constituents of the caecal contents was studied in male rats of ages varying from 4 wk to 3 mth in experiments lasting from 10 days to 3 mth. All the test compounds...article 1974
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Ormai, S. (author), Hagenbeek, A. (author), Palkovits, M. (author), van Bekkum, D.W. (author), Radiobiologisch Instituut TNO (author)The changes in lymphocyte kinetics induced by the lymphocyte mobilizing agent polymethacrylic acid (PMAA) were studied in the normal rat. Quantitative data are presented concerning the degree of lymphocyte mobilization in the spleen and in various lymph nodes at different times after PMAA administration. Data were also obtained regarding the...article 1973
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Molenaar, P.C. (author), Polak, R.L. (author), Nickolson, V.J. (author), Medisch Biologisch Laboratorium TNO (author)Slices from rat brain cortex were incubated for either 5 or 60 min in a medium containing [3H]choline and 4.7 or 25 mM KCl. Bioassayable ACh and labelled ACh were determined in the incubation medium, in the total tissue homogenate and in subcellular fractions. Raising the KCl concentration from 4.7 to 25 mM stimulated the release and synthesis...article 1973
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- Boorman, G.A. (author), Zurcher, C. (author), Hollander, C.F. (author), Feron, V.J. (author), Centraal instituut voor voedingsonderzoek Instituut voor experimentele gerontologie TNO Radiobiologisch Instituut (author) article 1973
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Radiobiologisch Instituut TNO (author), van den Berg, K.J. (author), Betel, I. (author)Chemicals/CAS: 2 amino 2 methylpropionic acid, 62-57-7; amino acid, 65072-01-7; concanavalin A, 11028-71-0; sodium, 7440-23-5; Amino Acids; Aminoisobutyric Acids; Concanavalin A, 11028-71-0; Cyclopentanes; Sodium, 7440-23-5article 1973
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Instituut voor experimentele gerontologie TNO (author), Dicke, K.A. (author), van Noord, M.J. (author), Maat, B. (author)The colony forming unit culture (CFU C) in the thin layer agar colony technique is considered to be representative for hemopoietic stem cells (HSC), according to studies in mouse and monkey bone marrow. Using this in vitro assay as a guide, stem cell concentrates were prepared from monkey and human bone marrow by repeated density gradient...article 1973
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Medisch Biologisch Labortorium TNO (author), Westerveld, A. (author), Visser, R.P.L.S. (author), Freeke, M.A. (author), Bootsma, D. (author)The PGK activity was assayed in diploid, hyperdiploid, tetraploid, and hybrid cells all originating from the same Chinese hamster cell line (DON line). A relationship between gene multiplicity and enzyme activity was observed. Selective pressure on the HGPRT locus by growth of hybrid cells in the presence of 8-azaguanine resulted in decreased...article 1972
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van Putten, L.M. (author), Lelieveld, P. (author), Radiobiologisch Instituut TNO (author)The sensitivity of resting spleen colony-forming cells in normal mouse bone marrow and of rapidly-proliferating spleen colony-forming cells in repopulating mouse spleen to a number of bis-chloro-aethyl-amines was determined. The rapidly-growing cells were more sensitive to each of the agents than the resting cells. The equal degree of...article 1971
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- Offers, S. (author), Bentvelzen, P. (author), Radiobiologisch Instituut TNO (author) article 1971
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van den Berg, K.J. (author), Betel, I. (author), Radiobiologisch Instituut TNO (author)Chemicals/CAS: 2 amino 2 methylpropionic acid, 62-57-7; carbon, 7440-44-0; thymidine, 50-89-5; tritium, 10028-17-8; Aminoisobutyric Acids; Carbon Isotopes; Lectins; Thymidine, 50-89-5; Tritium, 10028-17-8article 1971
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de Groot, A.P. (author), Til, H.P. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Yeast grown on hydrocarbons according to the n-paraffin process of The British Petroleum Company Ltd. was fed to groups of male and female rats at dietary levels of 10, 20 and 30% for 1 yr. Two control diets were used, one being similar to the yeast diet but with soya-bean meal substituted for yeast and the other being the institute's stock diet...article 1970