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Medisch Biologisch Labortorium TNO (author), Polak, R.L. (author), Sellin, L.C. (author), Thesleff, S. (author)The acetylcholine (ACh) content and spontaneous and evoked release of ACh in rat extensor digitorum longus (EDL) muscles were determined by pyrolysis mass fragmentography. The determinations were made on muscles paralysed by local application of botulinum toxin (BoTx) type A, on unpoisoned muscles, surgically denervated or reinnervated muscles....article 1981
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Centraal Instituut voor Voedingsonderzoek TNO (author), Spit, B.J. (author), Wibowo, A.A.E. (author), Ferron, V.J. (author), Zielhuis, R.L. (author)Electron microscopical studies were carried out on the kidneys of rabbits given s.c. injections of 0 (control), 0.25 or 0.50 mg lead acetate/kg b.w. 3 times a week during 14 weeks. At the end of the experimental period the animals had lead blood levels of 60, 500 and 600 ??g/1 whole blood respectively. Treatment-related renal changes were found...article 1981
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Krump-Konvalinkova, V. (author), van den Berg, K.J. (author), Radiobiologisch Instituut TNO (author)All normal cells are thought to carry genetic information for oncogenic transformation, which, on activation to continuous expression. might make the cell cancerous. The presently known transforming retroviruses contain transforming genes which were probably derived by recombination of a slow oncogenic retrovirus with cellular sequences closely...article 1980
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Zelle, B. (author), Reynolds, R.J. (author), Kottenhagen, M.J. (author), Schuite, A. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)Chinese hamster ovary cells were used to compare the cytotoxicity and mutagenicity of far-UV radiation emitted by a low-pressure mercury, germicidal lamp (wavelength predominantly 254 nm) with that of near-UV radiation emitted by a fluorescent lamp with a continuous spectrum (Westinghouse 'Sun Lamp'), of which only the radiation with wavelengths...article 1980
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- van Zwieten, M.J. (author), Solleveld, H.A. (author), Lindsey, J.R. (author), Instituut voor experimentele gerontologie TNO (author) article 1980
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Kruisbeek, A.M. (author), Steinmeier, F.A. (author), Instituut voor experimentele gerontologie TNO (author)Much data support the notion that with increasing age a decline in T cell effector function occurs. In the present study, qualitative rather than quantitative age-related changes in vitro alloreactive cytotoxic T lymphocyte (CTL) responses were observed. The level of specific alloreactive CTL responses was not consistently lower in aged mice,...article 1980
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Bleichrodt, J.F. (author), Roos-Verheij, W.S.D. (author), Medisch Biologisch Laboratorium TNO (author)Under conditions where the reversion of an amber mutant of bacteriophage ?? by ??-rays is enhanced by subjecting the irradiated phage to SOS repair, ??-ray-induced reversion of two T7 ambers is not influenced by this error-prone bacterial repair system. The survival of T7 ??-irradiated under anoxic conditions is somewhat enhanced by SOS repair,...article 1980
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Vos, O. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: cysteine, 4371-52-2, 52-89-1, 52-90-4; mercaptamine, 156-57-0, 60-23-1; n (1 adamantylmethyl)thioglycolamidine, 60833-81-0article 1980
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- Grollé, T. (author), Kuiper, J. (author), Hoofdgroep Maatschappelijke Technologie TNO (author) article 1980
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- Bol, J. (author), van Overeem, E.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1980
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Guinan, M.E. (author), Astrup, T. (author), Gaubius instituut TNO (author)The arteries of the rat usually possess considerably higher endothelium-related fibrinolytic activity than corresponding veins. This finding contrasts observations in most other species, including man. The use of the rat in experimental work on thrombotic vascular disease should be evaluated with due regard to the specific properties of the...article 1980
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Wade, M.H. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)The role of the pyrimidine dimer in cell killing, DNA synthesis and repair has been studied by utilizing the light-requiring DNA-repair mechanism of photo-reactivation in UV-irradiated chicken-embryo fibroblasts. Survival, as measured by colony-forming ability at 41??C, is increased in cells left in the light. The initial inhibition of DNA...article 1980
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Meihuizen, S.P. (author), Blansjaar, N. (author), Instituut voor experimentele gerontologie TNO (author)Hepatocyte morphology of the three zones of the liver lobule was evaluated by stereological analysis in 3-month-old and 35-month-old virgin female WAG/Rij rats. In the old rats, the volume of the nucleus and cytoplasm, and volume densities of smooth endoplasmic reticulum and lysosomes were increased in all areas of the liver lobule, while the...article 1980
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Smokovitis, A. (author), Astrup, T. (author), Gaubius instituut TNO (author)Rabbit skin, normally of low fibrinolytic activity, and guinea-pig skin, of medium activity, after crush injury or after the intradermal or subcutaneous injection of aluminum hydroxide, show a remarkable increase in fibrinolytic activity. The activity is caused by a plasminogen activator and is related to blood vessels. Occasionally, intense...article 1980
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Vos, O. (author), Luiten, F. (author), Ploemacher, R.E. (author), Medisch Biologisch Laboratorium TNO (author)Treatment of mice with high doses of endotoxin (ET) affected the CFU(s) population in bone marrow, spleen and liver. By 7 days after injection the number of CFU(s) in bone marrow had decreased and the number in spleen and liver had increased. The experimental data show that if mice were irradiated and reconstituted with bone marrow 7 days after...article 1980
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Knook, D.L. (author), Sleyster, E.C. (author), Teutsch, H.F. (author), Instituut voor Experimentele Gerontologie TNO (author)Chemicals/CAS: glucose 6 phosphate dehydrogenase, 37259-83-9, 9001-40-5; Glucosephosphate Dehydrogenase, EC 1.1.1.49article 1980
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Dienske, H. (author), van Vreeswijk, W. (author), Koning, H. (author), Primatencentrum TNO (author)13 laboratory-born female monkeys were allowed to remain with their mothers for about 4 mo and were subsequently singly caged in rooms where they were able to see other monkeys. Ss that did not see mothers caring for their infants neglected their own firstborn. In contrast, Ss that were allowed to observe separately caged mother–infant pairs...article 1980
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Plooy, A.C.M. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)Ten platinum (Pt) coordination complexes with different ligands, comprising both Pt(II) and Pt(IV) complexes of which the cis-compounds all possessed at least some anti-tumour activity and the trans-compounds were inactive, were tested as to their effect on cell survival and the induction and repair of DNA damage in cultured Chinese hamster...article 1980
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- Feron, V.J. (author), van den Heuvel, P.D. (author), Koeter, H.B.W.M. (author), Beems, R.B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author) article 1980
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de Koning-Verest, I.F. (author), Medisch Biologisch Laboratorium TNO (author)The metabolism of glutamate, taken as an index of the metabolic state of the brain, was studied in brains of 3-, 12- and 30-month-old rats. Following the injection of a mixture of [3H]acetate and d-[2-14C]glucose, the brain levels of glutamate and aspartate were decreased in 30-month-old rats when compared with those of 3-month-old rats. No...article 1980