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Kerkenaar, A. (author), Organisch Chemisch Instituut TNO (author)Chemicals/CAS: metalaxyl, 57837-19-1; mithramycin, 18378-89-7article 1981
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Magchielse, T. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: tubocurarine chloride, 57-94-3, 57-95-4, 8006-51-7article 1981
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Hagenbeek, A. (author), Martens, A.C.M. (author), Radiobiologisch Instituut TNO (author)The efficacy of extracorporeal irradiation of the blood (ECIB) in combination with cell mobilization by dextran sulfate (DS; MW 17,000) was investigated in a rat model for human acute myelocytic leukemia. Repeated injections with DS (q 3 hr) induced a significant increase in the number of peripheral leukemic cells, i.e., up to 4.5 times the...article 1981
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Vriesendorp, H.M. (author), Heidt, P.J. (author), Zurcher, C. (author), Radiobiologisch Instituut TNO (author)Procedures for total and selective gastrointestinal decontamination of dogs are described. The selective procedure removed only Gram negative aerobic bacteria, yeast and fungi. Dogs receiving total decontamination were less susceptible to the GI syndrome following total body irradiation (TBI) than dogs receiving conventional care. After TBI and...article 1981
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Spit, B.J. (author), Feron, V.J. (author), Hendriksen, C.F.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The hepatic angiosarcoma studied was from a male Wistar rat having been exposed to vinyl chloride monomer (VCM) by the oral route for 120 weeks. Widened sinusoids lined by large electron-lucent, spindle-shaped tumor cells and membrane-bound nuclear-free structures were seen in the transitional zone between the tumor mass and the adjacent liver...article 1981
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Schellekens, H. (author), Weimar, W. (author), de Reus, A. (author), Bolhuis, R.L.H. (author), Cantell, K. (author), Instituut voor Experimentele Gerontologie TNO (author)Chemicals/CAS: Adjuvants, Immunologic; Antibodies, Viral; Interferons, 9008-11-1article 1981
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Klein, J.C. (author), Radiobiologisch Instituut TNO (author)In vitro assays that permit cloning of tumour cells in soft agar have been improved during the last 5 years. Two of them are claimed to be useful as test systems for the screening of new anticancer drugs and even for drug sensitivity testing of individual human tumours in devising individualized cancer chemotherapy regimens. Three assays were...article 1981
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Wade, D.R. (author), Lohman, P.H.M. (author), Mattern, I.E. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)A commercial sample of the tuberculostatic drug isoniazid (INH) was found to have a weak mutagenic activity towards Salmonella typhimurium strains TA100 and TA1535. The addition of a rat or mouse liver homogenate to the test system decreased the mutagenic effect of INH. Hydrazine, an impurity of the INH sample, was also weakly mutagenic in...article 1981
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Creemers, P. (author), Radiobiologisch Instituut TNO (author)Sera from normal mice and mice bearing murine mammary tumor virus (MTV)-induced tumors showed cytotoxic reactions to the MTV-producing Mm5mt/cl cell line. The reaction could be blocked by the addition of MTV, but not of purified gp52 and p28. In sera from tumor bearers, cytotoxic responses ranged from 15 to 66%; reactivity was generally highest...article 1981
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Vink, G.J. (author), Davis, P.B. (author), Hooftman, R.N. (author), Mattern, I.E. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: aroclor, 12767-79-2; benzo[a]pyrene, 50-32-8; mesylic acid ethyl ester, 62-50-0; mesylic acid methyl ester, 66-27-3; triaziquone, 68-76-8article 1981
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Benschop, H.P. (author), Berends, F. (author), de Jong, L.P.A. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: soman, 96-64-0; Organophosphorus Compounds; Soman, 96-64-0article 1981
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Rijken, D.C. (author), Wijngaards, G. (author), Welbergen, J. (author), Gaubius instituut TNO (author)Human plasminogen activators were compared immunologically in both a double-diffusion technique and quenching experiments on the fibrinolytic activities of the activators. Antisera against HMW and LMW urokinase and an antiserum against highly purified tissue plasminogen activator from human uterus were used. It was found that uterine tissue...article 1981
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Hooisma, J. (author), de Krijger, J. (author), de Groot, D.M.G. (author), Medisch Biologisch Laboratorium TNO (author)Previously tropic effects of extracts from whole chick embryos and from innervated muscles on cultured muscle cells were described. The present study demonstrated similar effects of extracts from 10-days denervated chick muscles. Extracts from innervated as well as from denervated muscles exsanguinated in vivo with saline prior to dissection...article 1981
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Sonneveld, P. (author), Mulder, J.A. (author), Radiobiologisch Instituut (author)The distribution kinetics of adriamycin in the rat were analyzed by using a multicompartment mathematical model. The set of a priori unknown model parameters, the drug rate constants, were estimated from 48 hr multicompartment drug distribution data by applying multivariate system identification techniques. Simultaneously, the information in all...article 1981
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Hagenbeek, A. (author), Martens, A.C.M. (author), Radiobiologisch Instituut TNO (author)Results of three different regimens of extracorporeal irradiation of the blood (ECIB) are compared (1 X 20,2 X 10, and 4 X 5hr) in a rat model for human acute myelocytic leukemia. The D0 for X rays of leukemic cells in the blood was 68 cGy. The transit dose varied from 380 to 660 cGy. Evaluation was performed by follow-up of the number of...article 1981
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Wolthuis, O.L. (author), Benschop, H.P. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)Anaesthetized, atropinized rats were posioned with 6x LD50 soman (1,2,2-trimethylpropyl methylphosphonofluoridate). Purified acetylcholinesterase, injected i.v. 75 min later, was rapidly inhibited, presumably by soman stored in a 'depot' from which it was gradually released. Existence of a depot is supported by the effect of a soman-simulator (...article 1981
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Nooijen, W.J. (author), Koppert, P.W. (author), Gaubius instituut TNO (author)A specific glucagon antiserum was generated in rabbits using a derivatisation of the methionine residue in glucagon. A sensitive and specific assay for glucagon has been developed. Interference with the assay system by plasma factors was abolished by both extraction of plasma samples and the production of glucagon-free plasma for each individual...article 1981
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Kluft, C. (author), Los, N. (author), Gaubius instituut TNO (author)A procedure to demonstrate two forms of ??2-antiplasmin in plasma, a plasminogen-binding and a non-plasminogen-binding one, is described. The procedure involves crossed immunoelectrophoresis using antiserum against ??2-antiplasmin, with, in the first dimension electrophoresis, lys-plasminogen added to the plasma and the agarose gel. A discrete...article 1981
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...article 1981
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Radiobiologisch Instituut TNO (author), Sonneveld, P. (author), van Bekkum, D.W. (author)Adriamycin (ADR) accumulates in well-perfused organs in the rat. This effect is especially evident for long periods in marrow and spleen of healthy animals. In rats bearing the Brown Norway Acute Myeloid Leukaemia (BNML) the in vitro distribution is significantly different. Maximum ADR levels in those organs which are morphologically infiltrated...article 1981