Searched for: subject:"Animals"
(1,401 - 1,420 of 1,459)

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document
Vos, O. (author), Wilschut, I.J.C. (author), Medisch Biologisch Laboratorium TNO (author)
Mobilization of CFUs from haemopoietic tissues into circulation was studied after injection of different bacterial lipopolysaccharides (LPS), zymosan, phytohaemagglutinin (PHA), concanavalin A (Con A), trypsin and di-isopropyl-fluorophosphate-inhibited trypsin. All bacterial LPS used gave an increase of CFUs in the peripheral blood at 1 h after...
article 1979
document
Feron, V.J. (author), Kruysse, A. (author), Immel, H.R. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, salivation, nasal discharge,...
article 1979
document
Pouwels, P.H. (author), de Groot, G.P. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: tryptophan, 6912-86-3, 73-22-3; Antibiotics, Aminoglycoside; DNA-Directed RNA Polymerases, EC 2.7.7.6; Heparin, 9005-49-6; Rifampin, 13292-46-1; RNA, Bacterial; Tryptophan, 73-22-3
article 1979
document
Polak, R.L. (author), Molenaar, P.C. (author), Medisch Biologisch Laboratorium TNO (author)
A new procedure is described for the estimation of ACh by pyrolysis-gas chromatography/mass spectrometry. ACh iodide and the iodides of ACh-d16 or propionylcholine are slowly demethylated at 250??C by pyrolysis on the tip of a glass probe after insertion into the heated entrance of a glass tube leading to a packed capillary column. The volatile...
article 1979
document
Smokovitis, A. (author), Astrup, T. (author), Gaubius instituut TNO (author)
Fibrinolytic activity (caused by a plasminogen activator) in the spinal cord was highest in the rat, lowest in the rabbit, and intermediate in the guinea pig. In all species the activity was highest in relation to the pia mater. The central spinal canal was active in the rat and the rabbit, but mostly inactive in the guinea pig. Foci of activity...
article 1978
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Tulleken, C.A.F. (author), van Dieren, A. (author), Mollevanger, W.J. (author), van Eijck, P. (author), Inst. Med. Phys., TNO, Utrecht, Netherlands (author)
In a group of 21 cats, the middle cerebral artery pressure (MCAP) was recorded by means of a catheter introduced into the artery at its origin, just distal to the occlusion. The effects of hypertension, hypercapnia, and hypocapnia were studied. In a group of five cats, both middle cerebral arteries (MCA) were catheterized and the pressure was...
article 1978
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Tanger, H.J. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
A method is described whereby open field behaviour of rats can be automatically registered using a TV camera, a video converter, an X-Y recorder and a papertape puncher. Use is made of the scanning properties of the TV camera to obtain the X and Y coordinates of the rat's position and to print this position on an X-Y recorder to obtain the...
article 1978
document
Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 hr/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal...
article 1978
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Mattern, I.E. (author), Greim, H. (author), Medisch Biologisch Laboratorium TNO (author)
Bacterial systems for the screening of chemical substances for mutagenic potential are receiving widespread attention. Now that many laboratories have introduced these test systems and a large number of substances has been tested, discrepancies in the results have become apparent. To discuss this problem, a workshop was organized at Neuherberg ...
article 1978
document
Widmer, M.B. (author), Balner, H. (author), Primatencentrum TNO (author)
Ten antisera containing antibodies directed against specificities controlled by the Ia1 locus of rhesus monkeys were tested for their ability to inhibit the MLC reaction. In cultures with responding cells from the serum producer, all sera with anti-Ia1, activity depressed the stimulatory capacity of cells carrying the Ia1 antigen in question. In...
article 1978
document
Sonneveld, P. (author), Radiobiologisch Instituut TNO (author)
Adriamycin (ADR)-induced cardiomyopathy was studied in a rat model by means of electrocardiograms (ECGs), light microscopy, and determination of heart weight. Pretreatment with D-α-tocopherol (α-T) 24 hours prior to a high dose of ADR diminishes cardiotoxic effects, as judged by ECG changes, decreases in heart weight, and histologic changes. The...
article 1978
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van Putten, L.M. (author), Smink, T. (author), Radiobiologisch Instituut TNO (author)
Chemicals/CAS: misonidazole, 13551-87-6; Nitroimidazoles; Radiation-Sensitizing Agents
article 1978
document
von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)
A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...
article 1978
document
Vos, O. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: Lipopolysaccharides
article 1978
document
Hooisma, J. (author), Slaaf, D.W. (author), Meeter, E. (author), Stevens, W.F. (author), Medisch Biologisch Laboratorium TNO (author)
The influence of various neural explants on the morphology and the survival of chick muscle fibers was studied. A method was developed to evaluate the condition of the muscle fibers using the following four morphological parameters: cross striation, thickness, number of fibers and absence of vacuoles. Chick as well as mouse spinal cord explants...
article 1978
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Stevens, W.F. (author), Slaaf, D.W. (author), Hooisma, J. (author), Magchielse, T. (author), Meeter, E. (author), Medisch Biologisch Laboratorium TNO (author)
A less complicated source of neurons suitable for this type of studies is the parasympathetic ciliary ganglion. In the pigeon and in the chick this ganglion is known to contain only two classes of neurons, both of which are cholinoceptive and cholinergic and that innervate the muscle fibres of the choroid plexus of the eye, the sphincter iridis...
article 1978
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Maat, B. (author), Radiobiologisch Instituut TNO (author)
Recent data on extrapulmonary colony formation after heparin administration are inconclusive. A systemic study of this topic was undertaken with 4 experimental tumour systems and 2 distinct periods of reduced clotting capacity in rats and mice. I.v. injection of various numbers of tumour cells into i.p. heparinized animals leads to: Significant...
article 1978
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van der Waaij, D. (author), Tieleman-Speltie, T.M. (author), Roeck de - Houben, A.M.J. (author), Radiobiologisch Instituut TNO (author)
Lethally irradiated conventional mice were killed at daily intervals after irradiation. A high correlation was found between the occurrence of bacterial over-growth in the digestive tract and invasion into the regional lymph nodes the spleen and the blood. By oral contamination of mice with quite high doses of either an exogenous or an...
article 1978
document
Widmer, M.B. (author), Balner, H. (author), Primatencentrum TNO (author)
The genetic basis for MLC reactivity in rhesus monkeys was further investigated. Cells from an intra-RhLA recombinant monkey were MLC reactive with those of an SD-identical sib and with each of two sets of homozygous typing cells carrying either paternal haplotype. Also, cells from a pair of RhLA- identical sibs reacted in MLC with each other,...
article 1978
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Kilbey, B.J. (author), Igali, S. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)
A statement of general principles and minimal criteria for the screening of chemicals for potential mutagenicity in man that may be used as guidelines for regulatory agencies and industrial organisations. To make clear the potentialities and current limitations of short-term mutagenicity testing for the prediction of genetic and carcinogenic...
article 1978
Searched for: subject:"Animals"
(1,401 - 1,420 of 1,459)

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