Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: Expert opinions on the state of affairs and the way forward

Acute effects on brain cholecystokinin-like concentration and anxiety-like behaviour in the female rat upon a single injection of 17β-estradiol

A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices

Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs

Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3

Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity

The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps

In ovo inoculation of chicken embryos with probiotic bacteria and its effect on posthatch Salmonella susceptibility

Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression

Dynamics of the microbiota in response to host infection

The probiotic mixture VSL#3 mediates both pro- and anti-inflammatory responses in bone marrow-derived dendritic cells from C57BL/6 and BALB/c mice

Of monkeys and men: A metabolomic analysis of static and dynamic urinary metabolic phenotypes in two species

Inhibition of the central melanocortin system decreases brown adipose tissue activity

Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin

Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology

Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice, a translational model for atherosclerosis

How to improve housing conditions of laboratory animals: The possibilities of environmental refinement

Role of caveolin-1 in fibrotic diseases

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human