Searched for: subject:"Animals"
(81 - 100 of 1,459)

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Saccenti, E. (author), Tenori, L. (author), Verbruggen, P. (author), Timmerman, M.E. (author), Bouwman, J. (author), van der Greef, J. (author), Luchinat, C. (author), Smilde, A.K. (author)
Background: Metabolomics has attracted the interest of the medical community for its potential in predicting early derangements from a healthy to a diseased metabolic phenotype. One key issue is the diversity observed in metabolic profiles of different healthy individuals, commonly attributed to the variation of intrinsic (such as (epi)genetic...
article 2014
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Kim, E.S. (author), Cha, Y. (author), Ham, M. (author), Jung, J. (author), Kim, S.G. (author), Hwang, S. (author), Kleemann, R. (author), Moon, A. (author)
A crucial role of the inflammatory lipid sphingosine-1-phosphate (S1P) in breast cancer aggressiveness has been reported. Recent clinical studies have suggested that C-reactive protein (CRP) has a role in breast cancer development. However, limited information is available on the molecular basis for the expression of CRP and its functional...
article 2014
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Baumans, V. (author), van Loo, P.L.P. (author)
Housing systems for captive animals have often been designed on the basis of economic and ergonomic considerations, such as equipment, costs, space, workload, ability to observe the animals and to maintain a certain degree of hygiene, with little or no consideration for animal welfare. Environmental refinement can be defined as any modification...
article 2013
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Gvaramia, D. (author), Blaauboer, M.E. (author), Hanemaaijer, R. (author), Everts, V. (author)
Fibrosis underlies the pathogenesis of numerous diseases and leads to severe damage of vital body organs and, frequently, to death. Better understanding of the mechanisms resulting in fibrosis is essential for developing appropriate treatment solutions and is therefore of upmost importance. Recent evidence suggests a significant antifibrotic...
article 2013
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van der Weerdt, C.A. (author), Vonder, M.R. (author)
Het doel van het project Smart Dairy Farming (SDF) is het ondersteunen van melkveehouders bij de verzorging van individuele dieren, om daarmee een goede gezondheid, een langer leven en een langere productietijd van de koe te bewerkstelligen. Daartoe ontwikkelt Smart Dairy Farming sensoren en andere technologische hulpmiddelen, beslismodellen,...
report 2013
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van der Weerdt, C.A. (author), Vonder, M.R. (author)
Het doel van het project Smart Dairy Farming (SDF) is het ondersteunen van melkveehouders bij de verzorging van individuele dieren, om daarmee een goede gezondheid, een langer leven en een langere productietijd van de koe te bewerkstelligen. Daartoe ontwikkelt Smart Dairy Farming sensoren en andere technologische hulpmiddelen, beslismodellen,...
report 2013
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Strikwold, M. (author), Spenkelink, B. (author), Woutersen, R.A. (author), Rietjens, I.M.C.M. (author), Punt, A. (author)
In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like the no observed adverse...
article 2013
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)
The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...
article 2013
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Coulier, L. (author), Muilwijk, B. (author), Bijlsma, S. (author), Noga, M. (author), Tienstra, M. (author), Attali, A. (author), van Aken, H. (author), Suidgeest, E. (author), Tuinstra, T. (author), Luider, T.M. (author), Hankemeier, T. (author), Bobeldijk, I. (author)
Analysis of metabolites in biofluids by gas chromatography-mass spectrometry (GC-MS) after oximation and silylation is a key method in metabolomics. The GC-MS method was modified by a modified vial design and sample work-up procedure in order to make the method applicable to small volumes of cerebrospinal fluid (CSF), i. e. 10 μL, with similar...
article 2013
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van der Weerdt, C.A. (author), Vonder, M.R. (author)
Het doel van het project Smart Dairy Farming (SDF) is het ondersteunen van melkveehouders bij de verzorging van individuele dieren, om daarmee een goede gezondheid, een langer leven en een langere productietijd van de koe te bewerkstelligen. Daartoe ontwikkelt Smart Dairy Farming sensoren en andere technologische hulpmiddelen, beslismodellen,...
report 2013
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Teunis, M. (author), Corsini, E. (author), Smits, M. (author), Madsen, C.B. (author), Eltze, T. (author), Ezendam, J. (author), Galbiati, V. (author), Gremmer, E. (author), Krul, C.A.M. (author), Landin, A. (author), Landsiedel, R. (author), Pieters, R. (author), Rasmussen, T.F. (author), Reinders, J. (author), Roggen, E. (author), Spiekstra, S. (author), Gibbs, S. (author)
At present, the identification of potentially sensitizing chemicals is carried out using animal models. However, it is very important from ethical, safety and economic point of view to have biological markers to discriminate allergy and irritation events, and to be able to classify sensitizers according to their potency, without the use of...
article 2013
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Zeegers, M.P. (author), Nekeman, D. (author), Khan, H.S. (author), van Dijk, B.A.C. (author), Goldbohm, R.A. (author), Schalken, J. (author), Shajahan, S. (author), Pearlman, A. (author), Oddoux, C. (author), van den Brandt, P.A. (author), Schouten, L.J. (author), Ostrer, H. (author), TNO Preventie en Gezondheid (author)
Background:Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate...
article 2013
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van der Weerdt, C.A. (author), Vonder, M.R. (author)
Het doel van het project Smart Dairy Farming (SDF) is het ondersteunen van melkveehouders bij de verzorging van individuele dieren, om daarmee een goede gezondheid, een langer leven en een langere productietijd van de koe te bewerkstelligen. Daartoe ontwikkelt Smart Dairy Farming sensoren en andere technologische hulpmiddelen, beslismodellen,...
report 2013
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Harb, H. (author), van Tol, E.A.F. (author), Heine, H. (author), Braaksma, M. (author), Gross, G. (author), Overkamp, K. (author), Hennen, M. (author), Alrifai, M. (author), Conrad, M.L. (author), Renz, H. (author), Garn, H. (author)
Background: Oral supplementation with probiotic bacteria can protect against the development of allergic and inflammatory diseases. Objective: The aim of this study was to investigate potential immunomodulatory and allergy-protective effects of processed Lactobacillus rhamnosus GG (LGG)-derived supernatants early in life in neonatal mice....
article 2013
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Khedoe, P.P.S.J. (author), Wong, M.C. (author), Wagenaar, G.T.M. (author), Plomp, J.J. (author), van Eck, M. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Hiemstra, P.S. (author), Berbée, J.F.P. (author)
Background: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation, airways obstruction and emphysema, and is a risk factor for cardiovascular disease (CVD). However, the contribution of these individual COPD components to this increased risk is unknown. Therefore, the aim of this study was to determine the...
article 2013
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Alić, L. (author), van Vliet, M. (author), Wielopolski, P.A. (author), ten Hagen, T.L.M. (author), van Dijke, C.F. (author), Niessen, W.J. (author), Veenland, J.F. (author)
Experimental evidence supports an association between heterogeneity in tumor perfusion and response to chemotherapy/radiotherapy, disease progression and malignancy. Therefore, changes in tumor perfusion may be used to assess early effects of tumor treatment. However, evaluating changes in tumor perfusion during treatment is complicated by...
article 2013
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Wopereis, S. (author), Radonjic, M. (author), Rubingh, C. (author), van Erk, M. (author), Smilde, A. (author), van Duyvenvoorde, W. (author), Cnubben, N. (author), Kooistra, T. (author), van Ommen, B. (author), Kleemann, R. (author)
The prevalence of diabetes mellitus Type 2 could be significantly reduced by early identification of subjects at risk, allowing for better prevention and earlier treatment. Glucose intolerance (GI) is a hallmark of the prediabetic stage. This study aims at identifying 1) prognostic biomarkers predicting the risk of developing GI later in life...
article 2012
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Louisse, J. (author)
doctoral thesis 2012
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Mariman, R. (author), Kremer, S.H.A. (author), van Erk, M. (author), Lagerweij, T. (author), Koning, F. (author), Nagelkerken, L. (author)
Background: Host-microbiota interactions in the intestinal mucosa play a major role in intestinal immune homeostasis and control the threshold of local inflammation. The aim of this study was to evaluate the efficacy of probiotics in the recurrent trinitrobenzene sulfonic acid (TNBS)-induced colitis model and gain more insight into protective...
article 2012
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Reus, A.A. (author), Usta, M. (author), Kenny, J.D. (author), Clements, P.J. (author), Pruimboom-Brees, I. (author), Aylott, M. (author), Lynch, A.M. (author), Krul, C.A.M. (author)
An in vivo photomicronucleus test (MNT) using rat skin, the target organ for photoirritancy and carcinogenicity, was recently described. The assay was evaluated using fluoroquinolone (FQ) antibiotics with varying degrees of phototoxic potency (i.e. sparflocacin [SPFX], lomefloxacin [LOFX], ciprofloxacin [CIFX], levofloxacin [LEFX], gemifloxacin ...
article 2012
Searched for: subject:"Animals"
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