Searched for: subject:"Animals"
(401 - 416 of 416)

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document
Vos, O. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: Lipopolysaccharides
article 1978
document
Hooisma, J. (author), Slaaf, D.W. (author), Meeter, E. (author), Stevens, W.F. (author), Medisch Biologisch Laboratorium TNO (author)
The influence of various neural explants on the morphology and the survival of chick muscle fibers was studied. A method was developed to evaluate the condition of the muscle fibers using the following four morphological parameters: cross striation, thickness, number of fibers and absence of vacuoles. Chick as well as mouse spinal cord explants...
article 1978
document
Maat, B. (author), Radiobiologisch Instituut TNO (author)
Recent data on extrapulmonary colony formation after heparin administration are inconclusive. A systemic study of this topic was undertaken with 4 experimental tumour systems and 2 distinct periods of reduced clotting capacity in rats and mice. I.v. injection of various numbers of tumour cells into i.p. heparinized animals leads to: Significant...
article 1978
document
van der Waaij, D. (author), Tieleman-Speltie, T.M. (author), Roeck de - Houben, A.M.J. (author), Radiobiologisch Instituut TNO (author)
Lethally irradiated conventional mice were killed at daily intervals after irradiation. A high correlation was found between the occurrence of bacterial over-growth in the digestive tract and invasion into the regional lymph nodes the spleen and the blood. By oral contamination of mice with quite high doses of either an exogenous or an...
article 1978
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Kepner, L.A. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of HS-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer 'delayed deaths' were seen...
article 1978
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Creemers, P. (author), Ouwehand, J. (author), Bentveizen, P. (author), Radiobiologisch Instituut TNO (author)
The vaccines used in this study were derived from purified murine mammary tumor virus (MuMTV) preparations. Approximately 60% of the protein fractions consisted of the major viral membrane glycoprotein gp52. Inoculation sc of 10 pg MuMTV-S-derived vaccine significantly delayed the appearance of primary mammary tumors in GR and BALB/cfC3H mice ...
article 1978
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van der Waaij, D. (author), Vossen, J.M. (author), Korthals Altes, C. (author), Hartgrink, C. (author), Radiobiologisch Instituut TNO (author)
Antibiotic decontamination of the digestive tract can suppress or eliminate all microorganisms in this tract that are sensitive to the antibiotics used for decontamination. Experimental work in animals has indicated that colonization resistance (CR) decreases to extremely low values during decontamination as a result of the suppression of the...
article 1977
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Lubbe, F.H. (author), Rossi, G. (author), Zaalberg, O.B. (author), Medisch Biologisch Laboratorium TNO (author)
A method is described for isolation of antibody forming cells with the help of cluster formation. This was achieved by incubating spleen cells from immunized mice with sheep erythrocytes at 37°C. During incubation rabbit anti mouse immunoglobulin serum was present in order to facilitate the formation of clusters. Thereafter the clusters were...
article 1976
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Vos, O. (author), Budke, L. (author), Grant, G.A. (author), Medisch Biologisch Laboratorium TNO (author)
In tissue culture, protection against X irradiation by a number of cysteamine derivatives was studied and the results were compared with data obtained in mice. Compounds with a covered SH group, like WR 638, cysteamine phosphate, WR 2721 and AE AE 48527, showed practically no protection when dissolved in tissue culture medium, but developed a...
article 1976
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de Groot, A.P. (author), Slump, P. (author), Feron, V.J. (author), van Beek, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To find out whether alkali treated proteins possess nephrotoxic properties, feeding studies were conducted with drastically treated soybean protein and casein, and also with lysinoalanine (LAL), the amino acid known to be formed in proteins subjected to high pH at an elevated temperature. The feeding of synthesized LAL to rats at dietary levels...
article 1976
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Vos, O. (author), Grant, G.A. (author), Budke, L. (author), Medisch Biologisch Laboratorium RVO-TNO (author)
The effect of diamide on the radiosensitivity of T cells was investigated under oxic and anoxic conditions. The compound was found to sensitize the cells under both conditions. Under oxic conditions, exposure for 10 min before and during irradiation to 0.1, 0.5 and 1.0 mM diamide produced dose modifying factors of 0.81, 0.60 and 0.55,...
article 1976
document
van Putten, L.M. (author), Kram, L.K.J. (author), van Dierendonck, H.H.C. (author), Radiobiologisch Instituut TNO (author)
In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and...
article 1975
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Broerse, J.J. (author), Radiobiologisch Instituut TNO (author)
Values of the relative biological effectiveness (RBE) of fast neutrons for effect on normal tissue depend not only on the neutron energy and the dose, but also on the type of tissue irradiated. Values of the RBE of 15 MeV neutrons are reviewed for rapidly proliferating rodent tissue, such as mouse bone marrow, mouse intestine and rat skin...
article 1974
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Dicke, K.A. (author), van Noord, M.J. (author), Maat, B. (author), Instituut voor experimentele gerontologie TNO (author)
The colony forming unit culture (CFU C) in the thin layer agar colony technique is considered to be representative for hemopoietic stem cells (HSC), according to studies in mouse and monkey bone marrow. Using this in vitro assay as a guide, stem cell concentrates were prepared from monkey and human bone marrow by repeated density gradient...
article 1973
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van Putten, L.M. (author), Lelieveld, P. (author), Radiobiologisch Instituut TNO (author)
The sensitivity of resting spleen colony-forming cells in normal mouse bone marrow and of rapidly-proliferating spleen colony-forming cells in repopulating mouse spleen to a number of bis-chloro-aethyl-amines was determined. The rapidly-growing cells were more sensitive to each of the agents than the resting cells. The equal degree of...
article 1971
document
Offers, S. (author), Bentvelzen, P. (author), Radiobiologisch Instituut TNO (author)
article 1971
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