Searched for: subject:"Animals"
(1 - 16 of 16)
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Westerterp, M. (author), Berbée, J.F.P. (author), Delsing, D.J.M. (author), Jong, M.C. (author), Gijbels, M.J.J. (author), Dahlmans, V.E.H. (author), Offerman, E.H. (author), Romijn, J.A. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
Mice that overexpress human apolipoprotein C-I (apoC-I) homozygously (APOC1+/+ mice) are protected against obesity and show cutaneous abnormalities. Although these effects can result from our previous observation that apoC-I inhibits FFA generation by LPL, we have also found that apoC-I impairs the uptake of a FFA analog in adipose tissue. In...
article 2007
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Goudriaan, J.R. (author), Dahlmans, V.E.H. (author), Teusink, B. (author), Ouwens, D.M. (author), Febbraio, M. (author), Maassen, J.A. (author), Romijn, J.A. (author), Havekes, L.M. (author), Voshol, P.J. (author), Gaubius Instituut TNO (author)
CD36 (fatty acid translocase) is involved in high-affinity peripheral fatty acid uptake. Mice lacking CD36 exhibit increased plasma free fatty acid and triglyceride (TG) levels and decreased glucose levels. Studies in spontaneous hypertensive rats lacking functional CD36 link CD36 to the insulin-resistance syndrome. To clarify the relationship...
article 2003
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Muurling, M. (author), Jong, M.C. (author), Mensink, R.P. (author), Hornstra, G. (author), Dahlmans, V.E.H. (author), Pijl, H. (author), Voshol, P.J. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Previous studies have shown that energy restriction (ER) or low-fat (LF) diets have beneficial effects on high-fat (HF) diet-induced obesity and non-insulin-dependent diabetes. However, comparison between ER and low-fat diet regarding the effect on insulin resistance and lipid metabolism has not been reported. After inducing insulin resistance...
article 2002
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Koopmans, S.J. (author), Jong, M.C. (author), Que, I. (author), Dahlmans, V.E.H. (author), Pijl, H. (author), Radder, J.K. (author), Frölich, M. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Aims/hypothesis. Insulin resistance for glucose metabolism is associated with hyperlipidaemia and high blood pressure. In this study we investigated the effect of primary hyperlipidaemia on basal and insulin-mediated glucose and on non-esterified fatty acid (NEFA) metabolism and mean arterial pressure in hyperlipidaemic transgenic mice...
article 2001
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Goudriaan, J.R. (author), Tacken, P.J. (author), Dahlmans, V.E.H. (author), Gijbels, M.J.J. (author), van Dijk, K.W. (author), Havekes, L.M. (author), Jong, M.C. (author), Gaubius Instituut TNO (author)
It has previously been reported that mice lacking the VLDL receptor (VLDLR-/-) exhibit normal plasma lipid levels and a modest decrease in adipose tissue mass. In the present study, the effect of VLDLR deficiency on profound weight gain was studied in mice. Obesity was induced either by feeding of a high-fat, high-calorie (HFC) diet or by...
article 2001
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Jong, M.C. (author), Rensen, P.C.N. (author), Dahlmans, V.E.H. (author), van der Boom, H. (author), van Berkel, T.J.C. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated hepatic uptake of TG-rich lipoproteins and/or the lipoprotein lipase (LPL)-mediated hydrolysis of TG. Accordingly, apoC3 knockout (apoC3-/-) mice are hypotriglyceridemic. In the present study,...
article 2001
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Post, S.M. (author), de Roos, B. (author), Vermeulen, M. (author), Afman, L. (author), Jong, M.C. (author), Dahlmans, V.E.H. (author), Havekes, L.M. (author), Stellaard, F. (author), Katan, M.B. (author), Princen, H.M.G. (author), Gaubius Instituut TNO (author)
Cafestol, a diterpene present in unfiltered coffee, potently increases serum cholesterol levels in humans. So far, no suitable animal model has been found to study the biochemical background of this effect. We determined the effect of cafestol on serum cholesterol and triglycerides in different mouse strains and subsequently studied its...
article 2000
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Jong, M.C. (author), Hendriks, W.L. (author), van Vark, L.C. (author), Dahlmans, V.E.H. (author), Groener, J.E.M. (author), Havekes, L.M. (author), Gaubius instituut TNO (author)
The present study examined the relative contributions of the different pathways by which oxidatively modified VLDL (oxVLDL) promotes the uptake and intracellular accumulation of lipids in J774 macrophages. VLDL was oxidized for a maximum of 4 hours, resulting in an increase in thiobarbituric acid- reactive substances and an increased...
article 2000
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Gaubius instituut TNO (author), Jong, M.C. (author), Willems-van Dijk, K. (author), Dahlmans, V.E.H. (author), van der Boom, H. (author), Kobayashi, K. (author), Oka, K. (author), Siest, G. (author), Chan, L. (author), Hofker, M.H. (author), Havekes, L.M. (author)
We have shown previously that human apolipoprotein (apo)Cl transgenic mice exhibit hyperlipidaemia, due primarily to an impaired clearance of very-low-density lipoprotein (VLDL) particles from the circulation. In the absence of at least the low-density-lipoprotein receptor (LDLR), it was shown that APOCI overexpression in transgenic mice...
article 1999
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Jong, M.C. (author), Gijbels, M.J.J. (author), Dahlmans, V.E.H. (author), van Gorp, P.J.J. (author), Koopman, S.-J. (author), Ponec, M. (author), Hofker, M.H. (author), Havekes, L.M. (author), Gaubius instituut TNO (author)
Transgenic mice were generated with different levels of human apolipoprotein C1 (APOC1) expression in liver and skin. At 2 mo of age, serum levels of cholesterol, triglycerides (TG), and FFA were strongly elevated in APOC1 transgenic mice compared with wild-type mice. These elevated levels of serum cholesterol and TG were due mainly to an...
article 1998
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Jong, M.C. (author), Dahlmans, V.E.H. (author), Princen, H.M.G. (author), Hofker, M.H. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
To study the in vivo role of apolipoprotein (apo) C1 in lipoprotein metabolism, we have generated transgenic mice expressing the human apo C1 gene. Apo C1 is a small 6.6 kDa protein that is primarily synthesized by the liver and is present on chylomicrons, very low density lipoproteins (VLDL) and high density lipoproteins (HDL). In recent years,...
article 1998
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Jong, M.C. (author), van Ree, J.H. (author), Dahlmans, V.E.H. (author), Frants, R.R. (author), Hofker, M.H. (author), Havekes, L.M. (author), TNO Preventie en Gezondheid (author)
The function of apolipoprotein (apo) C1 in vivo is not clearly defined. Because transgenic mice overexpressing human apoC1 show elevated triacylglycerol (TG) levels, an as yet unknown role for apoC1 in TG metabolism has been suggested. Here we investigated directly the effect of the complete absence of apoC1 on very-low-density lipoprotein (VLDL...
article 1997
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Gaubius Instituut TNO (author), Jong, M.C. (author), Dahlmans, V.E.H. (author), Hofker, M.H. (author), Havekes, L.M. (author)
In the present study it was investigated whether apolipoprotein (apoE) can inhibit the lipoprotein lipase (LPL)-mediated hydrolysis of very-low-density-lipoprotein (VLDL) triacylglycerols (TAGs). Previous studies have suggested such an inhibitory role for apoE by using as a substrate for LPL either plasma VLDL or artificial TAG emulsions. To...
article 1997
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Jong, M.C. (author), Dahlmans, V.E.H. (author), van Gorp, P.J.J. (author), Breuer, M.L. (author), Mol, M.J.T.M. (author), van der Zee, A. (author), Frants, R.R. (author), Hofker, M.H. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Transgenic mice overexpressing human APOE*3Leiden are highly susceptible to diet-induced hyperlipoproteinemia and atherosclerosis due to a defect in hepatic uptake of remnant lipoproteins. In addition to the human APOE*3Leiden gene, these mice carry the human APOC1 gene (APOE*3Leiden- C1). To investigate the possible effect of simultaneous...
article 1996
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van Ree, J.H. (author), van den Broek, W.J.A.A. (author), Dahlmans, V.E.H. (author), Wieringa, B. (author), Frants, R.R. (author), Havekes, L.M. (author), Hofker, M.H. (author), TNO Preventie en Gezondheid (author)
Chemicals/CAS: Apolipoproteins E; Cholesterol, 57-88-5
article 1995
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van Ree, J.H. (author), van den Broek, W.J.A.A. (author), Dahlmans, V.E.H. (author), Groot, P.H.E. (author), Vidgeon-Hart, M. (author), Frants, R.R. (author), Wieringa, B. (author), Havekes, L.M. (author), Hofker, M.H. (author), TNO Preventie en Gezondheid (author)
Apolipoprotein (apo) E is a ligand for the receptor-mediated uptake of lipoprotein remnant particles. Complete absence of apo E in humans leads to a severe form of type III hyperlipoproteinemia. We have used targeted inactivation in murine embryonic stem cells, as also described by others, to specifically study the effects of heterozygous Apoe...
article 1994
Searched for: subject:"Animals"
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