Searched for: subject%3A%22Animals%22
(1 - 8 of 8)
document
Seifert, W.F. (author), Bosma, A. (author), Brouwer, A. (author), Hendriks, H.F.J. (author), Roholl, P.J.M. (author), van Leeuwen, R.E.W. (author), de Thiel van-Ruiter, G.C.F. (author), Seifert-Bock, I. (author), Knook, D.L. (author), TNO Preventie en Gezondheid (author)
Earlier studies have shown that retinoid administration suppresses the generation of hepatic fibrosis and stimulates its regression in normal (i.e., vitamin A-sufficient) carbon tetrachloride-treated rats. This study focuses on the possible role of a marginal or deficient vitamin A status on carbon tetrachloride-induced fibrosis. This...
article 1994
document
Kwekkeboom, J. (author), Princen, H.M.G. (author), van Voorthuizen, E.M. (author), Meijer, P. (author), Kempen, H.J.M. (author), Gaubius Instituut TNO (author)
Intracellular accumulation of 37°C of 50 μM [14C]taurocholic acid by hepatocytes of pig and rat, cultured for 24 hours, and by human hepatocytes, cultured for 12 hours, reached equilibrium after an incubation time of 1 to 2 hours. Maximum capacity to accumulate taurocholate intracellularly was assessed in 3-hour incubations with increasing...
article 1989
document
Horbach, G.J.M.J. (author), Princen, H.M.G. (author), van der Kroef, M. (author), van Bezooijen, C.F.A. (author), Yap, S.H. (author)
To investigate the regulation of age-related changes in albumin synthesis in the rat liver, total postnuclear RNA and polyribosomes, both membrane-bound and free, were prepared from livers of rats of different ages. By the use of a specific complementary DNA probe, the albumin mRNA sequence content was quantitated in these RNA fractions. These...
article 1984
document
Feron, V.J. (author), Hendriksen, C.F.M. (author), Speek, A.J. (author), Til, H.P. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A lifespan oral toxicity of vinyl chloride monomer (VCM) was carried out in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10% VCM solution in soya-bean oil. The VCM doses (actual...
article 1981
document
Radiobiologisch Instituut TNO (author), Sonneveld, P. (author), van Bekkum, D.W. (author)
Adriamycin (ADR) accumulates in well-perfused organs in the rat. This effect is especially evident for long periods in marrow and spleen of healthy animals. In rats bearing the Brown Norway Acute Myeloid Leukaemia (BNML) the in vitro distribution is significantly different. Maximum ADR levels in those organs which are morphologically infiltrated...
article 1981
document
Meihuizen, S.P. (author), Blansjaar, N. (author), Instituut voor experimentele gerontologie TNO (author)
Hepatocyte morphology of the three zones of the liver lobule was evaluated by stereological analysis in 3-month-old and 35-month-old virgin female WAG/Rij rats. In the old rats, the volume of the nucleus and cytoplasm, and volume densities of smooth endoplasmic reticulum and lysosomes were increased in all areas of the liver lobule, while the...
article 1980
document
Knook, D.L. (author), Instituut voor experimentele gerontologie TNO (author)
Highly purified suspensions of parenchymal, endothelial and Kupffer cells were prepared from the rat liver. The respective roles of these cell classes in the degradation of proteins was investigated by analysing the cellular distribution of two lysomal proteases. The specific arginine naphthylamidase activity was 2 times higher in Kupffer cells...
article 1977
document
Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P., (author)
A new oral cholecystographic medium called iocetamicacid was submitted to a toxicologic study in rats and dogs. Dosages, which were equivalent to 200 and 1000 mg of the compound per kilogram of body weight per day and were 5 times and 25 times the human routine dose, were administered daily for 3 weeks in order to establish whether the substance...
article 1969
Searched for: subject%3A%22Animals%22
(1 - 8 of 8)