Searched for: subject:"Animals"
(1 - 7 of 7)
document
Praaning-van Dalen, D.P. (author), Brouwer, A. (author), Knook, D.L. (author), Instituut voor experimentele gerontologie TNO (author)
The clearance of five radioactively labeled test substances - polyvinylpyrrolidone, colloidal albumin, antimony sulfur colloid, endotoxin, and heparin - by the reticuloendothelial system was studied after i.v. injection of these substances into rats. The participation of parenchymal, Kupffer, and endothelial liver cells could be determined after...
article 1981
document
Seifert, W.F. (author), Bosma, A. (author), Brouwer, A. (author), Hendriks, H.F.J. (author), Roholl, P.J.M. (author), van Leeuwen, R.E.W. (author), de Thiel van-Ruiter, G.C.F. (author), Seifert-Bock, I. (author), Knook, D.L. (author), TNO Preventie en Gezondheid (author)
Earlier studies have shown that retinoid administration suppresses the generation of hepatic fibrosis and stimulates its regression in normal (i.e., vitamin A-sufficient) carbon tetrachloride-treated rats. This study focuses on the possible role of a marginal or deficient vitamin A status on carbon tetrachloride-induced fibrosis. This...
article 1994
document
Bosma, A. (author), Seifert, W.F. (author), de Thiel van - Ruiter, G.C.F. (author), van Leeuwen, R.E.W. (author), Blauw, B. (author), Roholl, P. (author), Knook, D.L. (author), Brouwer, A. (author), Gaubius Laboratory TNO Preventie en Gezondheid Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Rats were malnourished for 12 months with a highly inadequate fat-rich, calorie-sufficient but otherwise poly-deficient liquid diet composed of mashed potatoes with mayonnaise, comparable with the nutritional intake of many chronic alcoholics. When alcohol was incorporated into this diet, administered as whisky in drinking water available ad...
article 1994
document
Praaning-Van Dalen, D.P. (author), Knook, D.L. (author), Instituut voor experimentele gerontologie TNO (author)
Chemicals/CAS: Serum Albumin, Bovine
article 1982
document
Knook, D.L. (author), Sleyster, E.C. (author), Teutsch, H.F. (author), Instituut voor Experimentele Gerontologie TNO (author)
Chemicals/CAS: glucose 6 phosphate dehydrogenase, 37259-83-9, 9001-40-5; Glucosephosphate Dehydrogenase, EC 1.1.1.49
article 1980
document
Knook, D.L. (author), Instituut voor experimentele gerontologie TNO (author)
Highly purified suspensions of parenchymal, endothelial and Kupffer cells were prepared from the rat liver. The respective roles of these cell classes in the degradation of proteins was investigated by analysing the cellular distribution of two lysomal proteases. The specific arginine naphthylamidase activity was 2 times higher in Kupffer cells...
article 1977
document
Instituut voor experimentele gerontologie TNO (author), Knook, D.L. (author), Blansjaar, N. (author), Sleyster, E.C. (author)
Non-parenchymal cell suspensions were prepared from rat livers by three different methods based on a collagenase, a pronase and a combined collagenase-pronase treatment. The highest yield of Kupffer and endothelial cells was obtained with the pronase treatment. Attempts were made for a further purification of these cells by Metrizamide density...
article 1977
Searched for: subject:"Animals"
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