Searched for: subject:"Animals"
(1 - 11 of 11)
document
Reijnen, M.M.P.J. (author), Holmdahl, L. (author), Kooistra, T. (author), Falk, P. (author), Hendriks, T. (author), van Goor, H. (author), TNO Kwaliteit van Leven (author)
Background: This study assessed the peritoneal fibrinolytic response during the first week after colonic surgery in rats with and without bacterial peritonitis, and possible modulation of the response by two hyaluronan-based antiadhesive agents. Methods: A colonic anastomosis was constructed in 90 male Wistar rats. Peritonitis was induced in...
article 2002
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Lansink, M. (author), Jong, M. (author), Bijsterbosch, M. (author), Bekkers, M. (author), Toet, K. (author), Havekes, L. (author), Emeis, J. (author), Kooistra, T. (author), Gaubius instituut TNO (author)
Several clinical studies have demonstrated an inverse relationship between circulating levels of estrogen and tissue-type plasminogen activator (t-PA). The present study was designed to test the hypothesis that estrogen lower plasma levels of t-PA by increasing its clearance from the bloodstream. 17α-Ethinyl estradiol (EE) treatment resulted in...
article 1999
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Nieuwenhuys, C.M.A. (author), Béguin, S. (author), Offermans, R.F.G. (author), Emeis, J.J. (author), Hornstra, G. (author), Heemskerk, J.W.M. (author), Gaubius Instituut TNO (author)
We investigated the effects of dietary polyunsaturated fatty acids (PUFAs) on blood lipids and processes that determine hemostatic potential: platelet activation, coagulation, and fibrinolysis. For 8 to 10 weeks, Wistar rats were fed a high-fat diet containing various amounts (2% to 16%) of n-3 PUFAs derived from fish oil (FO) or a diet enriched...
article 1998
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Kooistra, T. (author), Schrauwen, Y. (author), Arts, J. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The fibrinolytic activity of blood is to a large extent determined by the plasma level of tissue-type plasminogen activator (t-PA). Changes in the plasma level of t-PA are mainly achieved by the endothelium by two mechanisms: (a) a rapid, short-term release of t-PA, which occurs within minutes (acute release, regulated secretion) and (b) a long...
article 1994
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Emeis, J.J. (author), van den Hoogen, C.M. (author), Gaubius Laboratory IVVO-TNO, P.O. Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Pharmacological modulation of the in vivo induction of plasminogen activator inhibitor type-1 (PAI-1) synthesis was studied in rats using the induction of PAI-1 by endotoxin as a model system. Both the cyclooxygenase inhibitors acetylsalicylic acid and indomethacin enhanced PAI-1 induction. The combined cyclooxygenase-lipoxygenase inhibitor,...
article 1992
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Kooistra, T. (author), Opdenberg, J.P. (author), Toet, K. (author), Hendriks, H.F.J. (author), van den Hoogen, R.M. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Tissue-type plasminogen activator (t-PA) and its inhibitor, plasminogen activator inhibitor 1 (PAI-1), play an important role in regulating the fibrinolytic capacity of plasma. Both t-PA and PAI-1 are synthesized by the endothelium. We report that retinoic acid (vitamin A acid) and other retinoids rather specifically stimulate the production of...
article 1991
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Tranquille, N. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The acute release of tissue-type plasminogen activator (t-PA) was studied in perfused rat hindlegs. Pretreatment of rats with the protein synthesis inhibitor cycloheximide (2 mg/kg) at 1, 3 or 5 h prior to perfusion of rat hindlegs did not influence the amount of t-PA released by platelet-activating factor (20 nM) or bradykinin (1 μM). The...
article 1989
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Emeis, J.J. (author), Kluft, C. (author), Gaubius instituut TNO (author)
Platelet-activating factor (PAF-acether; 1-O-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) induced the release of plasminogen activator in rat, both in vivo and in perfused hind legs. The released plasminogen activator was shown by immunologic and functional criteria to be tissue-type plasminogen activator (t-PA). Release of t-PA by PAF...
article 1985
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Guinan, M.E. (author), Astrup, T. (author), Gaubius instituut TNO (author)
The arteries of the rat usually possess considerably higher endothelium-related fibrinolytic activity than corresponding veins. This finding contrasts observations in most other species, including man. The use of the rat in experimental work on thrombotic vascular disease should be evaluated with due regard to the specific properties of the...
article 1980
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Smokovitis, A. (author), Astrup, T. (author), Gaubius instituut TNO (author)
Rabbit skin, normally of low fibrinolytic activity, and guinea-pig skin, of medium activity, after crush injury or after the intradermal or subcutaneous injection of aluminum hydroxide, show a remarkable increase in fibrinolytic activity. The activity is caused by a plasminogen activator and is related to blood vessels. Occasionally, intense...
article 1980
document
Smokovitis, A. (author), Astrup, T. (author), Gaubius instituut TNO (author)
Fibrinolytic activity (caused by a plasminogen activator) in the spinal cord was highest in the rat, lowest in the rabbit, and intermediate in the guinea pig. In all species the activity was highest in relation to the pia mater. The central spinal canal was active in the rat and the rabbit, but mostly inactive in the guinea pig. Foci of activity...
article 1978
Searched for: subject:"Animals"
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