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Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author), Verlinde, J.D. (author), Boer, H.D. (author)
The experiments of Havens, Ward, Drill and Paul, a Neefe and his associates4, 5,~,~ and:Paul, Havens, Sabin and Philip 9 on human volunteers make the virus etiology of infectious hepatitis at the least highly probable. The virus seems to be present in the blood, the feces and perhaps in the urine and the throat washings. As the human experiment...
article 1948
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Hollander, C.F. (author), Instituut voor experimentele gerontologie TNO (author), GO RBI IVEG (author)
Cartilaginous tissue in the heart of rat has been described in literature by some as an ageing phenomenon, while others have observed it in young animals. Hearts of rats of different ages were studied for the occurence and localization of cartilaginous tissue. A cartilaginous focus has been regularly found in rats as young as 1 week old. This...
article 1968
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Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P. (author)
Studies in rats on iocetamic acid show that the LD50 levels of this compound compare favorably with those of a number of other oral cholecystographic agents. Pathologic effects are not found in rats and cats in studies of the subacute toxicity. Incompatibility with an anesthetic or a tranquilizer is not found. The elimination pattern of...
article 1969
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Centraal Instituut voor Voedingsonderzoek TNO (author), Janbroers, J.M. (author), Sanders, J.C. (author), Til, H.P. (author), Feron, V.J. (author), de Groot, A.P., (author)
A new oral cholecystographic medium called iocetamicacid was submitted to a toxicologic study in rats and dogs. Dosages, which were equivalent to 200 and 1000 mg of the compound per kilogram of body weight per day and were 5 times and 25 times the human routine dose, were administered daily for 3 weeks in order to establish whether the substance...
article 1969
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de Groot, A.P. (author), Til, H.P. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Yeast grown on hydrocarbons according to the n-paraffin process of The British Petroleum Company Ltd. was fed to groups of male and female rats at dietary levels of 10, 20 and 30% for 1 yr. Two control diets were used, one being similar to the yeast diet but with soya-bean meal substituted for yeast and the other being the institute's stock diet...
article 1970
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de Groot, A.P. (author), Til, H.P. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Yeast grown on hydrocarbons according to the gas-oil process was fed to rats at dietary levels of 10, 20 or 30% for 1 yr. Two control diets were used, one being similar to the yeast diets but containing soyabean-oil meal instead of yeast and the other being the institute's stock diet. The yeast diets had no effect on mortality, general condition...
article 1970
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van Putten, L.M. (author), Lelieveld, P. (author), Radiobiologisch Instituut TNO (author)
The sensitivity of resting spleen colony-forming cells in normal mouse bone marrow and of rapidly-proliferating spleen colony-forming cells in repopulating mouse spleen to a number of bis-chloro-aethyl-amines was determined. The rapidly-growing cells were more sensitive to each of the agents than the resting cells. The equal degree of...
article 1971
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Offers, S. (author), Bentvelzen, P. (author), Radiobiologisch Instituut TNO (author)
article 1971
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van den Berg, K.J. (author), Betel, I. (author), Radiobiologisch Instituut TNO (author)
Chemicals/CAS: 2 amino 2 methylpropionic acid, 62-57-7; carbon, 7440-44-0; thymidine, 50-89-5; tritium, 10028-17-8; Aminoisobutyric Acids; Carbon Isotopes; Lectins; Thymidine, 50-89-5; Tritium, 10028-17-8
article 1971
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Ormai, S. (author), Hagenbeek, A. (author), Palkovits, M. (author), van Bekkum, D.W. (author), Radiobiologisch Instituut TNO (author)
The changes in lymphocyte kinetics induced by the lymphocyte mobilizing agent polymethacrylic acid (PMAA) were studied in the normal rat. Quantitative data are presented concerning the degree of lymphocyte mobilization in the spleen and in various lymph nodes at different times after PMAA administration. Data were also obtained regarding the...
article 1973
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Molenaar, P.C. (author), Polak, R.L. (author), Nickolson, V.J. (author), Medisch Biologisch Laboratorium TNO (author)
Slices from rat brain cortex were incubated for either 5 or 60 min in a medium containing [3H]choline and 4.7 or 25 mM KCl. Bioassayable ACh and labelled ACh were determined in the incubation medium, in the total tissue homogenate and in subcellular fractions. Raising the KCl concentration from 4.7 to 25 mM stimulated the release and synthesis...
article 1973
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Boorman, G.A. (author), Zurcher, C. (author), Hollander, C.F. (author), Feron, V.J. (author), Centraal instituut voor voedingsonderzoek Instituut voor experimentele gerontologie TNO Radiobiologisch Instituut (author)
article 1973
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Radiobiologisch Instituut TNO (author), van den Berg, K.J. (author), Betel, I. (author)
Chemicals/CAS: 2 amino 2 methylpropionic acid, 62-57-7; amino acid, 65072-01-7; concanavalin A, 11028-71-0; sodium, 7440-23-5; Amino Acids; Aminoisobutyric Acids; Concanavalin A, 11028-71-0; Cyclopentanes; Sodium, 7440-23-5
article 1973
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Instituut voor experimentele gerontologie TNO (author), Dicke, K.A. (author), van Noord, M.J. (author), Maat, B. (author)
The colony forming unit culture (CFU C) in the thin layer agar colony technique is considered to be representative for hemopoietic stem cells (HSC), according to studies in mouse and monkey bone marrow. Using this in vitro assay as a guide, stem cell concentrates were prepared from monkey and human bone marrow by repeated density gradient...
article 1973
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Broerse, J.J. (author), Radiobiologisch Instituut TNO (author)
Values of the relative biological effectiveness (RBE) of fast neutrons for effect on normal tissue depend not only on the neutron energy and the dose, but also on the type of tissue irradiated. Values of the RBE of 15 MeV neutrons are reviewed for rapidly proliferating rodent tissue, such as mouse bone marrow, mouse intestine and rat skin...
article 1974
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Polak, R.L. (author), Molenaar, P.C. (author), Medisch Biologisch Laboratorium TNO (author)
Demethylation by sodium benzenethiolate has been used to analyse mixtures of isotopic variants of acetylcholine (ACh) by gas chromatography/mass spectrometry (GC/MS). The present experiments show that demethylation by pyrolysis is also suitable for the simultaneous determination of deuterium labelled variants of ACh by means of GC/MS. However,...
article 1974
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van Beek, L. (author), Feron, V.J. (author), de Groot, A.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Alkali treated spun soy isolate was fed to rats at dietary levels of 5, 10, and 20% for a period of 90 days. The results failed to reveal any adverse effects on general appearance, growth, feeding efficiency, hematological indices, blood serum values, urine composition, kidney function, organ weights, and gross and microscopic pathology except...
article 1974
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Padmos, P. (author)
other 1974
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Radiobiologisch Instituut TNO (author), Sindram, P.J. (author), Snow, G.B. (author), van Putten, L.M. (author)
Chemicals/CAS: folinate calcium, 1492-18-8, 51057-63-7; folinic acid, 58-05-9, 68538-85-2; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Leucovorin, 58-05-9; Methotrexate, 59-05-2
article 1974
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van Putten, L.M. (author), Kram, L.K.J. (author), van Dierendonck, H.H.C. (author), Radiobiologisch Instituut TNO (author)
In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and...
article 1975
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