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Pasma, W. (author), Wesselink, E.M. (author), van Buuren, S. (author), de Graaff, J.C. (author), van Klei, W.A. (author)Physiologic data from anesthesia monitors are automatically captured. Yet erroneous data are stored in the process as well. While this is not interfering with clinical care, research can be affected. Researchers should find ways to remove artifacts. The aim of the present study was to compare different artifact annotation strategies, and to...article 2021
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Pasma, W. (author), Peelen, L.M. (author), van den Broek, S. (author), van Buuren, S. (author), van Klei, W.A. (author), de Graaff, J.C. (author)Background: Intraoperative blood pressure has been suggested as a key factor for safe pediatric anesthesia. However, there is not much insight into factors that discriminate between children with low and normal pre-incision blood pressure. Our aim was to explore whether children who have a low blood pressure during anesthesia are different than...article 2020
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Zwart, J.J. (author), Richters, J.M. (author), Öry, F. (author), de Vries, J.I.P. (author), Bloemenkamp, K.W.M. (author), van Roosmalen, J. (author)Objective: To assess incidence of uterine rupture in scarred and unscarred uteri and its maternal and fetal complications in a nationwide design. Design: Population-based cohort study. Setting: All 98 maternity units in the Netherlands. Population: All women delivering in the Netherlands between August 2004 and August 2006 (n = 371 021). Methods...article 2009
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van der Schans, M.J. (author), Lander, B.J. (author), van der Wiel, H. (author), Langenberg, J.P. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)In continuation of our investigations on the toxicokinetics of the volatile nerve agents C(±)P(±)-soman and (±)-sarin, we now report on the toxicokinetics of the rather nonvolatile agent (±)-VX. A validated method was developed to determine blood levels of (±)-VX by means of achiral gas chromatography at blood levels ≥10 pg/ml. The ratio of the...article 2003
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Kornet, L. (author), Jansen, J.R.C. (author), te Nijenhuis, F.C.A.M. (author), Langewouters, G.J. (author), Versprille, A. (author), TNO Biomedical Instrumentation (author)1. The influence of mean pulmonary arterial pressure (mean P(pa)) on dynamic (C(d)) and pseudostatic compliance (C(ps)) of the pulmonary artery was studied at a constant and a changing heart rate. C(d) is the change in cross-sectional area (CSA) relative to the change in P(pa) throughout a heart cycle. C(pa) is the change in mean CSA relative to...article 1998
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TNO Prins Maurits Laboratorium (author), Langenberg, J.P. (author), de Jong, L.P.A. (author), Benschop, H.P. (author)Several p-nitrophenyl phosphoramidates with the general formula RO(NH2)P(O)OC6H4-p-NO2, in which R = CH2CH3, CH2CH2F, CH2CHF2, CH2CF3, CH2CH2CH2CH3, and CH2CH2Cl, as well as (NH2)2P(O)OC6H4-p-NO2 were administered intravenously to guinea pigs as pretreatment compounds for protection against the lethal effects of 1,2,2-trimethylpropyl...article 1996
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TNO Preventie en Gezondheid (author), Vanderkerken, K. (author), Goes, E. (author), de Raeve, H. (author), Radl, J. (author), van Camp, B. (author)The evolution of bone lesions in transplantable C57BL/KaLwRij 5T mouse myeloma (MM) has been followed in vivo. Mice were anaesthetised and a radiograph of the pelvis and hind legs was performed by a radiograph dedicated for mammography. This is the first description of an in vivo technique under experimental conditions whereby the development of...article 1996