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Verkerk, P.H. (author), Buitendijk, S.E. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)It is generally believed that non-differential misclassification will lead to a bias toward the null-value. However, using one graphical and one numerical example, we show that in situations where underestimation more than overestimation is the problem, non-differential misclassification may lead to a bias away from the null-value for...article 1992
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Schaapveld, K. (author), van de Water, H.P.A. (author), Bergsma, E.W. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)In the last few years prevention has again become the focus of attention because of various international developments such as the WHO strategy for Health for All by the year 2000. When resources are scarce, it is all the more important to set priorities. This applies to prevention as well as to curative care. In this paper, we describe a method...article 1992
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Coelingh, J.P. (author), van Wijk, A.J.M. (author), Cleijne, J.W. (author), Pleune, R. (author), TNO Milieu, energie en procesinnovatie (author)In The Netherlands it is foreseen that wind turbines will be installed on offshore locations in the North Sea before the year 2010. Therefore adequate knowledge of the offshore wind climate should be obtained, both for the estimation of energy yields and for the determination of wind load parameters. For this purpose databases of two offshore...article 1992
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van Eijsden, R.R. (author), Hoedemaeker, F.J. (author), Díaz, C.L. (author), Lugtenberg, B.J.J. (author), de Sylvia Pater, B. (author), Kijne, J.W. (author)As part of a strategy to determine the precise role of pea (Pisum sativum) lectin, Psl, in nodulation of pea by Rhizobium leguminosarum, mutations were introduced into the genetic determinant for pea lectin by site-directed mutagenesis using PCR. Introduction of a specific mutation, N125D, into a central area of the sugar-binding site resulted...article 1992
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Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Yonekawa, O. (author), Voskuilen, M. (author), Nieuwenhuizen, W. (author)In previous publications [e.g. Voskuilen, Vermond, Veeneman, Van Boom, Klasen, Zegers and Nieuwenhuizen (1987) J. Biol. Chem. 262, 5944-5946] we have shown that fibrin(ogen) chain fragment Aα-(148-160) contains a site that contributes to the acceleration of Glu-plasminogen activation by tissue-type plasminogen activator (t-PA). In contrast with...article 1992
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Centraal Instituut voor Voedingsonderzoek TNO (author), Huisman, J. (author), Heinz, T. (author), van der Poel, A.F.B. (author), van Leeuwen, P. (author), Souffrant, W.B. (author), Verstegen, M.W.A. (author)The faecal and ileal true protein digestibilities of the raw pea (Pisum sativum) varieties finale and frijaune and the ileal true protein digestibility of steam-processed common beans (Phaseolus vulgaris) were measured in piglets using the 15N-dilution technique. The faecal true protein digestibility of both pea varieties was about 97. The ileal...article 1992
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- Instituut CIVO-Toxicologie en Voeding TNO (author), van Faassen, A. (author), van 't Veer, P. (author), Bausch-Goldbohm, R.A. (author), Sturmans, F. (author), Hermus, R.J.J. (author) article 1992
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Hoofdgroep Maatschappelijke Technologie TNO (author), Duyzer, J.H. (author), Verhagen, H.L.M. (author), Weststrate, J.H. (author), Bosveld, F.C. (author)The dry deposition flux of NH3 to coniferous forest was determined by the micrometeorological gradient method using a 36m high tower. Aerodynamic characteristics of the site were studied, using a second tower erected in the forest 100m from the first. Fluxes and gradients of heat and momentum measured on both towers indicated a fairly...article 1992
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Instituut CIVO-Toxicologie en Voeding TNO (author), Groten, J.P. (author), Luten, J.B. (author), van Bladeren, P.J. (author)It has been shown that addition of extra calcium/phosphorus (Ca/P), zinc (Zn) and iron (Fe2+) to the diet results in a significant protection against cadmium (Cd) accumulation and toxicity in rats fed inorganic Cd salt. However, it is not clear whether the presence of these mineral supplements in the diet also protects against the Cd uptake from...article 1992
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- Instituut voor Bouwmaterialen en Bouwconstructies TNO (author) other 1992
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Medisch Biologisch Laboratorium TNO (author), Brouwer, D.H. (author), Brouwer, R. (author), de Mik, G. (author), Maas, C.L. (author), van Hemmen, J.J. (author)Respiratory exposure and dermal exposure of the hands and forearms to the pesticides chlorothalonil, thiophanate-methyl, thiram, and zineb during application and during crop activities have been measured on 18 farms for carnation culture in glass-covered greenhouses in the Netherlands. Farms were selected according to a 'worst case' strategy...article 1992
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Medisch Biologisch Laboratorium TNO (author), Jongen, M.J.M. (author), Engel, R. (author), Leenheers, L.H. (author)An HPLC method was developed for estimation of dermal exposure of greenhouse workers to the pesticide bupirimate. Chromatography was performed on a cyano-modified silica column with methanol-water (6:4 by volume) containing 5 g/L ammonium sulfate as eluent. UV detection at 310 nm was used for quantitation. Dermal exposure was assessed by letting...article 1992
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Daanen, H.A.M. (author), van de Linde, F.J.G. (author)Four noninvasive rewarming techniques for mildly hypothermic subjects were compared. Seven subjects were cooled in a water bath of 15°C for 2 h to an average esophageal temperature (Tes) of 36°C. Thereafter, the subjects were rewarmed by immersion of the body in a water bath of 42°C (Method 1), the body but not the extremities in water of 42°C ...article 1992
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Instituut CIVO-Toxicologie en Voeding TNO (author), Houben, G.F. (author), Abma, P.M.H. (author), van den Berg, H. (author), van Dokkum, W. (author), van Loveren, H. (author), Penninks, A.H. (author), Seinen, W. (author), Spanhaak, S. (author), Vos, J.G. (author), Ockhuizen, T. (author)Administration of the colour additive Caramel Colour III to rats has been associated with decreased numbers of lymphocytes and several other changes in the immune system, as well as in immune function parameters, specifically in animals fed a diet with a relatively low vitamin B6 content. The effects are caused by the imidazole derivative 2...article 1992
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Lokman, B.C. (author), van Santen, P. (author), Verdoes, J.C. (author), Kruse, J. (author), Leer, R.J. (author), Posno, M. (author), Pouwels, P.H. (author), Medisch Biologisch Laboratorium TNO (author)A cluster of three genes involved in D-xylose catabolism (viz. xylose genes) in Lactobacillus pentosus has been cloned in Escherichia coli and characterized by nucleotide sequence analysis. The deduced gene products show considerable sequence similarity to a repressor protein involved in the regulation of expression of xylose genes in Bacillus...article 1991
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van Noort, J.M. (author), van den Berg, P. (author), Mattern, I.E. (author), Medisch Biologisch Laboratorium TNO (author)A method for the visualization of individual proteases within a complex biological sample is described. In a single chromatographic step, proteases can be separated from other biomolecules by selective binding to immobilized bacitracin, a peptide antibiotic. Following desorption, proteases may be separated by SDS-polyacrylamide gel...article 1991
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van Noord-Zaadstra, B.M. (author), Looman, C.W.N. (author), Alsbach, H. (author), Habbema, J.D.F. (author), te Velde, E.R. (author), Karbaat, J. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)Objectives - To study the age of the start of the fall (critical age) in fecundity; the probability of a pregnancy leading to a healthy baby taking into account the age of the woman; and, combining these results, to determine the age dependent probability of getting a healthy baby. Design - Cohort study of all women who had entered a donor...article 1991
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Korteling, J.E. (author)Age-related differences in dual-task performance may be affected by factors such as skill integration and perceptual competition. Therefore these factors were examined in a dual-task experiment with young and older adults involving two one-dimensional compensatory tracking tasks. Single-task difficulty was individually adjusted for each subject....article 1991
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Jongen, M.J.M. (author), Ravensberg, J.C. (author), Engel, R. (author), Leenheers, L.H. (author), Medisch Biologisch Laboratorium TNO (author)Health hazard surveys have been conducted on Dutch bulb farms and in greenhouses used for cultivation of carnations in order to determine occupational exposure to the fungicides zineb and maneb. Occupational exposure is estimated by determining inhalatory and dermal exposure. Inhalatory exposure is measured by personal air sampling and dermal...article 1991
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Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author), Gijbels, M.J.J. (author), Visser, J.W.M. (author), Solleveld, H.A. (author), Broerse, J.J. (author), Zurcher, C. (author)Archival paraffin embedded material was used to examine whether additional quantitative criteria would be helpful to discriminate between histologically benign and malignant rat mammary tumours. To this end nuclear DNA content expressed as DNA ploidy index (DI) was measured using flow cytometry (FCM). A total of 63 benign and malignant mammary...article 1991