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van Weerden, E.J. (author), Huisman, J. (author)In a study with twelve pigs of 60-70 kg live weight provided with a re-entrant cannula at the end of the ileum, and twelve intact, non-cannulated pigs, the fate of dietary doses of 100 and 200 g isomalt/kg during gastrointestinal passage was examined. From sugar analyses in ileal chyme it was calculated that 0.43 and 0.30 of the isomalt consumed...article 1993
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- van Hoof, H.A.J.M. (author) article 1993
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Instituut CIVO-Toxicologie en Voeding TNO (author), den Besten, C. (author), van Bladeren, P.J. (author), Duizer, E. (author), Vervoort, J. (author), Rietjens, I.M.C.M. (author)In the present study the oxidative dehalogenation of a para-halogenated phenol was studied using pentafluorophenol and its non-para-halogenated analogue 2,3,5,6-tetrafluorophenol as model compounds. 19F NMR was used to characterize the metabolite patterns. In order to study the primary oxidation products of the microsomal cytochrome P450...article 1993
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Medisch Biologisch Laboratorium TNO (author), Verdoes, J.C. (author), Punt, P.J. (author), Schrickx, J.M. (author), van Verseveld, H.W. (author), Stouthamer, A.H. (author), van den Hondel, C.A.M.J.J. (author)A strategy, based on the usage of the amdS selection marker and a cosmid vector containing four copies of the glucoamylase gene (glaA), was developed to obtain glucoamylase (GLA)-overproducing A. niger strains. With this strategy, fungal strains carrying up to 200 copies of the glaA gene could be isolated at a relatively high frequency. In each...article 1993
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van Gijzen, M.B. (author)A group of preconditioners for systems of linear equations arising from finite element discretization, which is of increasing interest, is the class of element-by-element preconditioners. These preconditioners allow the solution of a system without the need to assemble the global stiffness matrix. The success of a preconditioner depends on how...article 1993
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Grøn, B. (author), Filion-Myklebust, C. (author), Benninck, A. (author), Nieuwenhuizen, W. (author), Matsueda, G.R. (author), Brosstad, F. (author), Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author)alpha-polymer formation, as opposed to gamma-chain dimerization has been considered a relatively late event in factor XIII-induced fibrin stabilization. Recently it has been shown, however, that plasma from healthy individuals and from patients with fibrinaemia contains small amounts of soluble fibrin/fibrinogen oligomers interlinked through...article 1992
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Verrips, G.H. (author), Frencken, J.E. (author), Kalsbeek, H. (author), ter Horst, G. (author), Filedt Kok-Weimar, T.L. (author), TNO Preventie en Gezondheid (author)The aim of this study was threefold: first, to assess the oral health of Turkish, Moroccan, Surinamese, Dutch and "other" 5-yr-old children living in Amsterdam; second, to identify risk indicators for caries, in addition to ethnicity; and third, to identify potential risk factors related to differences in caries experience in these children....article 1992
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de Lange, J. (author), van Eck, P. (author), Elliott, G.R. (author), de Kort, W.L.A.M. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)To overcome most of the disadvantages of current models to investigate percutaneous penetration of drugs or toxic substances, a model is proposed here based on the isolated pig ear, which is obtained at the slaughterhouse, and perfused with oxygenated blood from the same pig. To determine the viability of the preparations, we measured glucose...article 1992
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Brouwer, R. (author), Brouwer, D.H. (author), Tijssen, S.C.H.A. (author), van Hemmen, J.J. (author), Medisch Biologisch Laboratorium TNO (author)The relationship between the levels of dermal and respiratory exposure to pesticides and the amount of pesticide on the leaves of the plants has been studied during cutting of carnations in greenhouses. The study was focused on four pesticides and performed in 18 farms in the Netherlands. Dermal exposure measured by using long-sleeved cotton...article 1992
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Kalsbeek, H. (author), Verrips, E. (author), Dirks, O.B. (author), TNO Preventie en Gezondheid (author)A study was executed to investigate the relation between the use of fluoride tablets by children in the age period 1.5-6 yr on the one hand and the caries experience at the age of 6 and 15 yr and the prevalence of fluorosis at the age of 15 yr on the other hand. The year of birth of the child, the motivation of the mother to engage in preventive...article 1992
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Mattern, I.E. (author), van Noort, J.M. (author), van den Berg, P. (author), Archer, D.B. (author), Roberts, I.N. (author), van den Hondel, C.A.M.J.J. (author), Medisch Biologisch Laboratorium TNO (author)In the present study, the extracellular protease activity in a strain of the filamentous fungus Aspergillus niger was investigated and mutant strains deficient in the production of extracellular proteases were isolated. The major protease, which is responsible for 80-85% of the total activity, is aspergillopepsin A, a protein of ca. 43 kDa, the...article 1992
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Leer, R.J. (author), van Luijk, N. (author), Posno, M. (author), Pouwels, P.H. (author), Medisch Biologisch Laboratorium TNO (author)The DNA sequences of a 2.4 kb plasmid (p353-2) from Lactobacillus pentosus MD353 and a 1.9 kb plasmid (p8014-2) from Lactobacillus plantarum ATCC 8014 show 81.5% overall similarity. Both plasmids carry elements (replication protein gene, plus-origin and minus-origin of replication), which are typical of plasmids that replicate via a rolling...article 1992
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Verkerk, P.H. (author), Buitendijk, S.E. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)It is generally believed that non-differential misclassification will lead to a bias toward the null-value. However, using one graphical and one numerical example, we show that in situations where underestimation more than overestimation is the problem, non-differential misclassification may lead to a bias away from the null-value for...article 1992
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Schaapveld, K. (author), van de Water, H.P.A. (author), Bergsma, E.W. (author), Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author)In the last few years prevention has again become the focus of attention because of various international developments such as the WHO strategy for Health for All by the year 2000. When resources are scarce, it is all the more important to set priorities. This applies to prevention as well as to curative care. In this paper, we describe a method...article 1992
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Coelingh, J.P. (author), van Wijk, A.J.M. (author), Cleijne, J.W. (author), Pleune, R. (author), TNO Milieu, energie en procesinnovatie (author)In The Netherlands it is foreseen that wind turbines will be installed on offshore locations in the North Sea before the year 2010. Therefore adequate knowledge of the offshore wind climate should be obtained, both for the estimation of energy yields and for the determination of wind load parameters. For this purpose databases of two offshore...article 1992
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van Eijsden, R.R. (author), Hoedemaeker, F.J. (author), Díaz, C.L. (author), Lugtenberg, B.J.J. (author), de Sylvia Pater, B. (author), Kijne, J.W. (author)As part of a strategy to determine the precise role of pea (Pisum sativum) lectin, Psl, in nodulation of pea by Rhizobium leguminosarum, mutations were introduced into the genetic determinant for pea lectin by site-directed mutagenesis using PCR. Introduction of a specific mutation, N125D, into a central area of the sugar-binding site resulted...article 1992
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Instituut voor verouderings- en vaatziekten onderzoek TNO (author), Yonekawa, O. (author), Voskuilen, M. (author), Nieuwenhuizen, W. (author)In previous publications [e.g. Voskuilen, Vermond, Veeneman, Van Boom, Klasen, Zegers and Nieuwenhuizen (1987) J. Biol. Chem. 262, 5944-5946] we have shown that fibrin(ogen) chain fragment Aα-(148-160) contains a site that contributes to the acceleration of Glu-plasminogen activation by tissue-type plasminogen activator (t-PA). In contrast with...article 1992
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Centraal Instituut voor Voedingsonderzoek TNO (author), Huisman, J. (author), Heinz, T. (author), van der Poel, A.F.B. (author), van Leeuwen, P. (author), Souffrant, W.B. (author), Verstegen, M.W.A. (author)The faecal and ileal true protein digestibilities of the raw pea (Pisum sativum) varieties finale and frijaune and the ileal true protein digestibility of steam-processed common beans (Phaseolus vulgaris) were measured in piglets using the 15N-dilution technique. The faecal true protein digestibility of both pea varieties was about 97. The ileal...article 1992
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- Instituut CIVO-Toxicologie en Voeding TNO (author), van Faassen, A. (author), van 't Veer, P. (author), Bausch-Goldbohm, R.A. (author), Sturmans, F. (author), Hermus, R.J.J. (author) article 1992
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Hoofdgroep Maatschappelijke Technologie TNO (author), Duyzer, J.H. (author), Verhagen, H.L.M. (author), Weststrate, J.H. (author), Bosveld, F.C. (author)The dry deposition flux of NH3 to coniferous forest was determined by the micrometeorological gradient method using a 36m high tower. Aerodynamic characteristics of the site were studied, using a second tower erected in the forest 100m from the first. Fluxes and gradients of heat and momentum measured on both towers indicated a fairly...article 1992