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van Doorn, C. (author), Vink, M. (author), van der Poll, J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A gas chromatographic method, with electron capture detection and mass spectrometric confirmation, is described for the determination of chlorothalonil and its metabolite 4-hydroxy-2,5,6-trichloroisophtalonitrile (HTI) in water samples. Water is saturated with sodium chloride and acidified to pH < 2 with dilute sulfuric acid. After extraction...article 1995
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Kardinaal, A.F.M. (author), Aro, A. (author), Kark, J.D. (author), Riemersma, R.A. (author), van 't Veer, P. (author), Gomez-Aracena, J. (author), Kohlmeier, L. (author), Ringstad, J. (author), Martin, B.C. (author), Mazaev, V.P. (author), Delgado-Rodriguez, M. (author), Thamm, M. (author), Huttunen, J.K. (author), Martin-Moreno, J.M. (author), Kok, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Because antioxidants may play a role in the prevention of coronary heart disease by inhibiting the peroxidation of polyunsaturated fatty acids (PUFAs), the combined association of diet-derived antioxidants and PUFAs with acute myocardial infarction (MI) was investigated. This multicenter case- control study included 674 patients and 725 control...article 1995
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Papp, Z. (author), Driessen, B.J.F. (author), Technisch Physische Dienst TNO - TH (author)The paper presents an adaptive nonlinear (state-) feedback control structure, where the nonlinearities are implemented as smooth fuzzy mappings defined as rule sets. The fine tuning and adaption of the controller is realized by an indirect adaptive scheme, which modifies the parameters of the fuzzy mapping. The performance index gradients are...conference paper 1995
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Jonker, D. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)To compare the possible effects of microwave and conventional cooking on a range of common dietary components, mixed human diets containing beef, potatoes and vegetables were fed to groups of 10 male and 10 female Wistar rats for 13 wk. The diet ingredients were cooked by either of the methods in a normal and an abused manner, the latter...article 1995
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Vink, P. (author), Peeters, M. (author), Grundemann, R.W.M. (author), Smulders, P.G.W. (author), Kompier, M.A.J. (author), Dul, J. (author), TNO Preventie en Gezondheid (author)A step-by-step approach to better work, aimed at reducing mental and physical workload in office work, is evaluated. This approach is based on a strong commitment of the management in the enterprise, and on as much direct worker participation as possible. After every step the workers proposed how to continue and a steering group led by the...article 1995
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de Nooy, A.E.J. (author), Besemer, A.C. (author), van Bekkum, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The kinetics of the TEMPO-mediated oxidation of methyl α-D- glucopyranoside to sodium methyl α-D-glucopyranosiduronate were studied. An intermediate was found which was identified as the hydrated aldehyde. This was oxidised in the same manner as the alcohol, with pseudo first order rate constants ratio k(obs,ald)/k(obs,alc) = 7. The reaction...article 1995
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Attenborough, K. (author), Taherzadeh, S. (author), Bass, H.E. (author), Di, X. (author), Raspet, R. (author), Becker, G.R. (author), Gdesen, A. (author), Chrestman, A. (author), Daigle, G.A. (author), L' Esp‚rance, A. (author), Gabillet, Y. (author), Gilbert, K.E. (author), Li, Y.L. (author), White, J. (author), Naz, P. (author), Noble, J.M. (author), van Hoof, H.A.J.M. (author), TNO Fysisch en Elektronisch Laboratorium (author)The computational tools available for prediction of sound propagation through the atmosphere have increased dramatically during the past decade. The numerical techniques include analytical solutions for selected index of refraction profiles, ray trace techniques which include interaction with a complex impedance boundary, a Gaussian beam ray...article 1995
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Prins Maurits Laboratorium TNO (author), Absil, L.H.J. (author), Kodde, H.H. (author), Weerheijm, J. (author)Noise pollution around military training facilities caused by firing of explosives, artillery or large caliber guns poses a severe problem to neighbouring communities. One possible way to attenuate the blast is the construction of blast walls close to the explosion center. This paper describes a combined experimental and numerical study of the...conference paper 1995
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van den Brink, J.M. (author), van Zeijl, C.M.J. (author), Brons, J.F. (author), van den Hondel, C.A.M.J.J. (author), van Gorcom, R.F.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In this paper, we describe the cloning and molecular characterization of the Aspergillus niger cytochrome P450 reductase (CPR) gene, cprA. Attempts to clone the cprA gene by heterologous hybridization techniques were unsuccessful. Using the polymerase chain reaction (PCR) with degenerate primers based on conserved regions found in cpr genes from...article 1995
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Gaubius Instituut TNO (author), Lombardi, P. (author), Sijbrands, E.J.G. (author), van de Giessen, K. (author), Smelt, A.H.M. (author), Kastelein, J.J.P. (author), Frants, R.R. (author), Havekes, L.M. (author)Familial hypercholesterolemia (FH) results from mutations in the low density lipoprotein receptor (LDLR) gene. We applied denaturing gradient gel electrophoresis (DGGE) to screen for sequence variations in the coding and splice site consensus sequences of the LDLR gene. For amplification of each exon by the polymerase chain reaction (PCR),...article 1995
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Gaubius Instituut TNO (author), Bakker, A.H.F. (author), Weening-Verhoeff, E.J.D. (author), Verheijen, J.H. (author)To describe the role of the lysyl binding site in the interaction of tissue-type plasminogen activator (t-PA, FGK1K2P) with a forming fibrin clot, we performed binding experiments with domain deletion mutants GK1K2P, K2P, and the corresponding point mutants lacking the lysyl binding site in the absence and the presence of ε-amino caproic acid ...article 1995
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van Hoof, H.A.J.M. (author)Bij Defensie spelen vele zaken op het gebied van Beveiliging. TNO-FEL heeft als primaire taak de Krijgsmacht bij technisch wetenschappelijke vraagstukken te ondersteunen en dus ook op het gebied van de Beveiliging. De expertise bij TNOFEL ligt voornamelijk op het gebied van informatie-beveiliging en beveiliging van objecten en terreinen met...article 1995
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- Kocken, C.H.M. (author), Milek, R.L.B. (author), Lensen, T.H.W. (author), Kaslow, D.C. (author), Schoenmakers, J.G.G. (author), Konings, R.N.H. (author) article 1995
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Prins Maurits Laboratorium TNO (author), Duisterwinkel, A.E. (author), van Bokhoven, J.J.G.M. (author)A calorimetric method is described for the determination of adsorption and desorption of adsorptives that are liquid at room temperature, focussing on the sorption of water. Together with the isotherms, the sorption thermodynamics is determined in one experiment by determining the heat flow needed for generating the vapour and the heat flow...article 1995
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Lourenco, P.B. (author), Rots, J.G. (author), Blauwendraad, J. (author)Two models for the micro- and macro-analysis of masonry structures are presented. For the micro modeling of masonry, an interface failure criterion that includes a straight tension cut-off, the Coulomb friction law and an elliptical cap is proposed. The inelastic behavior includes tensile strength softening, cohesion softening, compressive...article 1995
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Vrouwenvelder, A.C.W.M. (author)The basic principles of probability based methods for the design and operation of offshore structures are presented. Basic formulae of the Load and Resistance Factor Design method, as well as the calibration principles are given and discussed. Design procedures in present day codes of practice are reviewed in the light of recent developments....conference paper 1995
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Centraal Instituut voor Voedingsonderzoek TNO (author), Huisman, M. (author), Koopman-Esseboom, C. (author), Lanting, C.I. (author), van der Paauw, C.G. (author), Tuinstra, L.G.M.T. (author), Fidler, V. (author), Weisglas-Kuperus, N. (author), Sauer, P.J.J. (author), Boersma, E.R. (author), Touwen, B.C.L. (author)The neurological optimality of 418 Dutch children was evaluated at the age of 18 months, in order to determine whether prenatal and breast milk mediated exposure to polychlorinated biphenyls (PCBs) and dioxins affected neurological development. Half of the infants were breast-fed, the other half were formula-fed. PCB concentrations in cord and...article 1995
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Kompier, M. (author), de Gier, E. (author), Smulders, P. (author), Draaisma, D. (author), TNO Preventie en Gezondheid (author)A comparative inventory of regulations, policies and practices in The Netherlands, Sweden, UK, Germany and France with regard to the prevention of work stress was carried out. In each country data were collected by means of interviews with key informants and through exploring relevant documents and literature. It was found that Sweden. The...article 1994
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Ganesh, S. (author), Sier, C.F.M. (author), Griffioen, G. (author), Vloedgraven, H.J.M. (author), de Boer, A. (author), Welvaart, K. (author), van de Velde, C.J.H. (author), van Krieken, J.H.J.M. (author), Verheijen, J.H. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)Human colorectal carcinogenesis has been shown previously to be associated with impressive changes in the tissue levels of plasminogen activators and their inhibitors, exemplified by an increase in the urokinase-type plasminogen activator (u-PA) and the inhibitors PAI-1 and PAI-2, and a decrease in tissue-type plasminogen activator (t-PA). In...article 1994
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Slagboom, P.E. (author), Droog, S. (author), Boomsma, D.I. (author), TNO Preventie en Gezondheid (author)Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telomeres terminate in tandemly arranged repeat arrays consisting of the (TTAGGG) motif. The length of these arrays in cells from human mitotic tissues is inversely related to the age of the donor, indicating telomere reduction with age. In addition...article 1994