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van Loon, K. (author), Breteler, M.J.M. (author), van Wolfwinkel, L. (author), Rheineck Leyssius, A.T. (author), Kossen, A.S. (author), Kalkman, C.J. (author), van Zaane, B. (author), Peelen, L.M. (author)Altered respiratory rate is one of the first symptoms of medical conditions that require timely intervention, e.g., sepsis or opioid-induced respiratory depression. To facilitate continuous respiratory rate monitoring on general hospital wards a contactless, non-invasive, prototype monitor was developed using frequency modulated continuous wave...article 2016
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Gärtner, F.R. (author), de Miranda, E. (author), Rijnders, M.E. (author), Freeman, L.M. (author), Middeldorp, J.M. (author), Bloemenkamp, K.W.M. (author), Stiggelbout, A.M. (author), van den Akker-van Marle, M.E. (author)Objectives To validate the Labor and Delivery Index (LADY-X), a new delivery-specific utility measure. Study Design and Setting In a test–retest design, women were surveyed online, 6 to 8 weeks postpartum and again 1 to 2 weeks later. For reliability testing, we assessed the standard error of measurement (S.E.M.) and the intraclass correlation...article 2015
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Amelink-Verburg, M.P. (author), Rijnders, M.E.B. (author), Buitendijk, S.E. (author), TNO Kwaliteit van Leven (author)Objective To assess the trends and patterns of referral from midwives to obstetricians within the Dutch maternity care system from 1988 to 2004, and the differences in referral patterns between nulliparous and parous women. Design A descriptive study. Setting The Dutch midwifery database (LVR1), which monitored 74% (1988) to 94% (2004) of all...article 2009
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Buijs, P.C. (author), Lambeek, L.C. (author), Koppenrade, V. (author), Hooftman, W.E. (author), Anema, J.R. (author), TNO Kwaliteit van Leven (author)Introduction: Workers with chronic low back pain (LBP) mean a heavy human and social-economic burden. Their medical histories often include different treatments without attention to work-relatedness or communication with occupational health providers, leaving them passive and medicalized in (outpatient) health care. So we developed and...article 2009
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TNO Preventie en Gezondheid (author), Peters, J.W.B. (author), Koot, H.M. (author), Boer, J.B.de (author), Passchier, J. (author), Bueno de Mesquita, J.M. (author), Jong, F.H.de (author), Duivenvoorden, H.J. (author), Tibboel, D. (author)Objectives. Pain exposure during early infancy affects the pain perception beyond infancy into childhood. The objective of this study was to examine whether major surgery within the first 3 months of life in combination with preemptive analgesia alters pain responses to immunization at 14 or 45 months and to assess whether these alterations are...article 2003
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Bessems, J.G.M. (author), de Groot, M.J. (author), Baede, E.J. (author), te Koppele, J.M. (author), Vermeulen, N.P.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)1. The formation of free radicals during enzyme catalysed oxidation of eight 3,5-disubstituted analogues of paracetamol (PAR) has been studied. A simple peroxidase system as well as cytochrome P450-containing systems were used. Radicals were detected by electron spin resonance (ESR) on incubation of PAR and 3,5-diCH3-, 3,5-diC2H5-, 3,5-ditC4H9-,...article 1998