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Derksen, G.C.H. (author), Holthoon, F.L. (author), Willemen, H.M. (author), Krul, C.A.M. (author), Franssen, M.C.R. (author), van Beek, T.A. (author)Madder, used as a red dye, contains anthraquinones, and some of these can react with DNA possibly causing mutagenic effects. This is especially true for 1,3-dihydroxyanthraquinones with a hydroxymethyl (e.g., lucidin 6, ibericin 10) or methyl group (e.g., rubiadin 9) at C-2. In this research, a new process was developed through which the...article 2021
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Bär, A. (author), Krul, C.A.M. (author), Jonker, D. (author), de Vogel, N. (author), TNO Voeding (author)Alpha-cyclodextrin glucosyltransferase (α-CGTase, EC 2.4.1.19) is an amylolytic enzyme used for the production of α-cyclodextrin (α-CD), a novel, soluble dietary fiber, from food-grade starch. The safety of an α-CGTase preparation obtained by batch fermentation from a recombinant strain of Escherichia coli K12 harboring the α-CGTase gene from...article 2004
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TNO Voeding (author), Kuilman-Wahls, M.E.M. (author), Vilar, M.S. (author), de Nijs-Tjon, L. (author), Maas, R.F.M. (author), Fink-Gremmels, J. (author)Cyclopiazonic acid and aflatoxin B1 are mycotoxins which can both be produced by the same moulds. Men can be exposed to these mycotoxins directly via ingestion of plant-derived food, as well as, indirectly via consumption of animal products. Although it is well known that aflatoxin B1 is mutagenic, contradictory results exist on the mutagenicity...article 2002
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Wilmer, J.W.G.M. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)The effects of 3 different retinoids (all-trans-retinol, all-trans-retinoic acid, and all-trans-retinyl acetate) on the mutagenic activity of cigarette-smoke condensate were investigated in Salmonella typhimurium TA98. Neither an enhancing nor an inhibitory effect of the retinoids on the mutagenicity of cigarette-smoke condensate was observed....article 1986
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- Instituut CIVO-Toxicologie en Voeding TNO (author), Willems, M.I. (author), de Raat, W.K. (author) article 1985
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Centraal Instituut voor Voedingsonderzoek TNO (author), de Raat, W.K. (author), Willems, M.I. (author), de Meijere, F.A. (author)It has been shown that the spontaneous revertants in the Ames test can depend on the amount and type of bottom agar on the plates. The most clear-cut effect was found with his G46 strains, carrying the ??uvrB mutation, and with the new hisG428 strain, TA102. Evidence of mutagenic impurities in agar has been found. Chemicals/CAS: agar, 9002-18-0;...article 1984
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Mattern, I.E. (author), Cocchiarella, L. (author), van Kralingen, C.G. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)Eleven platinum compounds with nitrogen donor ligands, previously tested for anti-tumour activity were studied for induction of prophage lambda and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic...article 1982
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Mattern, I.E. (author), van der Zwaan, W. (author), Vink, G.J. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: 4 nitroquinoline 1 oxide, 56-57-5; benzo[a]pyrene, 50-32-8; nitrofural, 59-87-0article 1981
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Wade, D.R. (author), Lohman, P.H.M. (author), Mattern, I.E. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)A commercial sample of the tuberculostatic drug isoniazid (INH) was found to have a weak mutagenic activity towards Salmonella typhimurium strains TA100 and TA1535. The addition of a rat or mouse liver homogenate to the test system decreased the mutagenic effect of INH. Hydrazine, an impurity of the INH sample, was also weakly mutagenic in...article 1981
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- Cocchiarella, L. (author), Mattern, I.E. (author), van Kralingen, C.G. (author), Medisch Biologisch Laboratorium TNO (author) article 1980