Comparing high altitude treatment with current best care in Dutch children with moderate to severe atopic dermatitis (and asthma): Study protocol for a pragmatic randomized controlled trial (DAVOS trial)

Background: About 10 to 20% of children in West European countries have atopic dermatitis (AD), often as part of the atopic syndrome. The full atopic syndrome also consists of allergic asthma, allergic rhinitis and food allergy. Treatment approaches for atopic dermatitis and asthma include intermittent anti-inflammatory therapy with...

Vertical emission profiles for Europe based on plume rise calculations

The vertical allocation of emissions has a major impact on results of Chemistry Transport Models. However, in Europe it is still common to use fixed vertical profiles based on rough estimates to determine the emission height of point sources. This publication introduces a set of new vertical profiles for the use in chemistry transport modeling...

Estimating wind velocities from limited sailplane flight data

The problem of estimating wind velocities from limited flight data recordings is considered, with application to sailplane flights in high-altitude mountain waves. Sailplane flight recorders routinely measure only GPS position and, infrequently, also airspeed and the problem is underdetermined. Maximum likelihood and maximum a posteriori...

The climatic-altitude chamber as development and validation tool

Two major trends can be identified for powertrain control in the next decade. The legislation will more and more focus on in-use emissions. Together with the global trend to reduce the CO 2 emissions, this will lead to an integral drive train approach. To develop and validate this integral drive train approach, the need for a new chapter in...

Real-Time Physiological and Psycho-Physiological Status Monitoring

Dismounted warfighting groups are increasingly recognizing the benefits of knowing the medical status information that body-worn computerized physiological sensor systems can provide. This report on real-time physiological and psycho-physiological status monitoring reviews: a) Physiological monitoring system architectures, methods for managing...

Acetazolamide improves cerebral oxygenation during exercise at high altitude

Acute mountain sickness is thought to be triggered by cerebral hypoxemia and be prevented by acetazolamide (Actz). The effect of Actz on cerebral oxygenation at altitude remains unknown. In 16 members of the 2005 Dutch Cho Oyu (8201 m, Tibet) expedition, the influence of Actz and exercise (750 mg PO daily) on heart rate, peripheral and regional...

Resistance index of frostbite as a predictor of cold injury in arctic operations

Cold-induced vasodilation (CIVD) is mentioned as a mechanism that may prevent the occurrence of local cold injuries. The magnitude of the CIVD reaction differs considerably between subjects and there were some indications that those subjects with a fast CIVD reaction with high amplitude had a reduced risk for cold injuries. The purpose of this...

Randvoorwaarden aan een verblijf op grote hoogte bij bestaande gezondheidsproblemen [Preconditions for a stay in high altitude areas in the case of existing health problems]

Various symptoms can arise during a stay in high altitude areas (above 2500 m), such as tissue hypoxia and in particular pulmonary and brain oedema. Patients with existing health problems can expect to develop more complaints or more severe complaints at an earlier stage. For a number of these patients a stay in high altitude areas should be...

Desloratadine shows no effect on performance during 6 h at 8,000 ft simulated cabin altitude

Sustained vigilance is required by pilots and crew during flight; therefore, the use of antihistamines with sedating properties is widely prohibited. The purpose of this study was to determine the effects of desloratadine, a long-acting, nonsedating antihistamine, on healthy volunteers placed under conditions of simulated cabin pressure. Methods...

Finger cold-induced vasodilation: A review

Cold-induced vasodilation (CIVD) in the finger tips generally occurs 5-10 min after the start of local cold exposure of the extremities. This phenomenon is believed to reduce the risk of local cold injuries. However, CIVD is almost absent during hypothermia, when survival of the organism takes precedence over the survival of peripheral tissue....

Hypoxic syncope in airline passengers

Cold induced peripheral vasodilation at high altitudes- a field study

A significant reduction in cold-induced vasodilation (CIVD) is observed at high altitudes. No agreement is found in the literature about acclimatization effects on CIVD. Two studies were performed to investigate the effect of altitude acclimatization on CIVD. In the first study 13 male subjects immersed the distal phalanx of the left middle...

Point Target Extinction and Scintillation as function of range at LAPTEX, Crete

The range performance of IRST sensors is partly determined by the propagation of the atmosphere. For low altitude targets the boundary layer of the atmosphere introduces a variety of effects due to inhomogeneities, for which model predictions are not yet well validated. For this reason NATO Research Study Group 5 on "Maritime Infrared Target and...