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Arts, J.H.E. (author), Kuper, C.F. (author), TNO Voeding (author)Although a number of test protocols have been developed to predict respiratory allergenic potential, none of these are widely applied or fully accepted. However, given the serious health problems caused by respiratory allergy and the ever-increasing stream of new chemicals into workplaces, early identification of chemical respiratory allergens...article 2003
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TNO BIBRA (author), Edwards, C.A. (author), Rumney, C. (author), Davies, M. (author), Parrett, A.M. (author), Dore, J. (author), Martin, F. (author), Schmitt, J. (author), Stahl, B. (author), Norin, E. (author), Midtvedt, T. (author), Rowland, I.R. (author), Heavey, P. (author), Köhler, H. (author), Stocks, B. (author), Schroten, H. (author)Objectives: Bacterial colonization of the infant gut may have important influences on the development of gastrointestinal, respiratory, and allergic disease. Early diet is a major determinant of the gut microflora. It is very difficult to carry out studies in human infants that can investigate the interaction of diet, flora, and mucosa. In this...article 2003
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Jansen, S.C. (author), van Dusseldorp, M. (author), Bottema, K.C. (author), Dubois, A.E.J. (author)Objective: To evaluate the scientific evidence for purported intolerance to dietary biogenic amines. Data Sources: MEDLINE was searched for articles in the English language published between January 1966 and August 2001. The keyword biogenic amin* was combined with hypersens*, allerg*, intoler*, and adverse. Additionally, the keywords histamine,...article 2003
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Kimber, I. (author), Dearman, R.J. (author), Penninks, A.H. (author), Knipples, L.M.J. (author), Buchanan, R.B. (author), Hammerberg, B. (author), Jackson, H.A. (author), Helm, R.M. (author)Because of the public concern surrounding the issue of the safety of genetically modified organisms, it is critical to have appropriate methodologies to aid investigators in identifying potential hazards associated with consumption of foods produced with these materials. A regent panel of experts convened by the Food and Agriculture Organization...article 2003
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de Pater, N. (author), Doekes, G. (author), Miedema, E. (author), Goede, H. (author), van Hemmen, J. (author), Heederik, D. (author)Beroepsmatige blootstelling aan meelstof kan leiden tot klachten aan de luchtwegen zoals astma en rhinitis. Deze klachten worden toegeschreven aan de in het stof aanwezige tarwe-allergenen en schimmel alpha-amylase. Het doel van het onderzoek is op basis van de resultaten een taakstelling te formuleren voor een reductie van de blootstelling aan...book 2003
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TNO Arbeid (author), van de Bovenkamp, J.M. (author), Gallis, R. (author), Miedema, E.P. (author)De beroepsziekte ‘latex allergie' komt steeds meer voor. Op verzoek van de branchebegeleidingscommissie in het kader van het arboconvenant algemene ziekenhuizen heeft TNO Arbeid een analyse gemaakt van de kosten en baten van de invoering van non-latex handschoenen. De analyse van kosten en baten richt zich onder meer op de vraag of de...report 2003
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Arts, J. (author), Kuper. F., (author)Beroepsastma en andere luchtwegallergieën komen veel voor. Het aantal allergieveroorzakende stoffen is namelijk groot en neemt nog altijd toe. Goede testmethoden om luchtwegallergieën op te sporen zijn daarom gewild. Ze zijn helaas ook moeilijk te ontwikkelen. TNO denkt echter een goede teststrategie gevonden te hebben. De dierproeven...article 2002
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Koppelman, S.J. (author), Vlooswijk, R.A.A. (author), Knippels, L.M.J. (author), Hessing, M. (author), Knol, E.F. (author), van Reijsen, F.C. (author), Bruijnzeel-Koomen, C.A.F.M. (author)Background: The serology of peanut allergy seems to be different in various parts of the world. We analyzed the composition of 13 samples of three varieties of peanut in order to compare their allergenic nature. Methods: Peanut cultivars that are commonly processed in the West were analyzed for protein content, protein composition, and Ara h 1...article 2001
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Kruisselbrink, A. (author), Heijne Den Bak-Glashouwer, M.J. (author), Havenith, C.E.G. (author), Thole, J.E.R. (author), Janssen, R. (author)Recent evidence suggests that chronic exposure to lactobacilli, which are part of the normal intestinal flora, inhibits the development of allergic disorders. Allergy is mediated by Th2 cells, which produce high levels of IL4 and IL5, and suppressive effects of lactic acid bacteria on the development of allergy have been attributed to their Th1...article 2001
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Magos, L. (author), TNO BIBRA International Ltd, Woodmansterne Rd, Carshalton, Surrey SM5 4DS, United Kingdom Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Chemicals/CAS: Biological Products; Ethylmercury Compounds; Food Additives; Pharmaceutical Preparations; Preservatives, Pharmaceutical; Thimerosal, 54-64-8article 2001
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Arts, J.H.E. (author), de Koning, M.W. (author), Bloksma, N. (author), Kuper, C.F. (author), TNO Voeding (author)Several acid anhydrides are known for their sensitizing and irritative properties. Since both irritation and respiratory allergy can cause changes of lung function, proper testing of allergen-dependent effects on the respiratory tract requires knowledge of the respiratory irritant effects. To study the latter effects, groups of female Brown...article 2001
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Knippels, L.M.J. (author), van der Kleij, H.P.M. (author), Koppelman, S.J. (author), Houben, G.F. (author), Penninks, A.H. (author), Felius, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Background: No adequate enteral sensitization models are available to study food allergy and the allergenicity of food proteins. To further validate an enteral brown Norway (BN) rat sensitization model under development, we studied specific protein recognition to determine whether a comparable pattern of proteins is recognized by the rat immune...article 2000
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Knippels, L.M.J. (author), Penninks, A.H. (author), van Meeteren, M. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)No adequate enteral sensitization models are available to study food allergy and allergenicity of food proteins. Using a previously described oral sensitization protocol to sensitize Brown Norway rats (BN) to food proteins, the influence of genetically-based strain-specific characteristics of the immune system on the outcome of oral...article 1999
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Koppelman, S. (author), Knulst, A.C. (author), Koers, W.J. (author), Penninks, A.H. (author), Peppelman, H. (author), Vlooswijk, R. (author), Pigmans, I. (author), van Duijn, G. (author), Hessing, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Hazelnuts are widely used in the food industry owing to their nutritive value and taste. The amount of hazelnut present in a recipe is usually considered as a mark of quality. On the other hand, contamination of foods that normally do not contain hazelnuts is a threat for patients with a hazelnut allergy. For this reason, the availability of a...article 1999
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Koppelman, S.J. (author), Wensing, M. (author), de Jong, G.A.H. (author), Knulst, A.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A new process for restructured meat and fish has been introduced to the market recently. Its main compound is casein, and it may therefore endanger patients with a milk allergy. Chemicals/CAS: Anti-Inflammatory Agents; Caseins; Lactoglobulins; Methylprednisolone, 83-43-2article 1999
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Knippels, L.M.J. (author), Penninks, A.H. (author), Smit, J.J. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Although several in vivo antigenicity assays using parenteral immunization are operational, no full validated enteral models are available to study food allergy and allergenicity of food proteins. To further validate a developed enteral Brown Norway (BN) rat food allergy model, systemic and local immune-mediated reactions were studied upon oral...article 1999
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Knippels, L.M.J. (author), Penninks, A.H. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Background: One of the major factors that may have negatively affected the results of many oral sensitization studies in animals has been unscheduled dietary preexposure of the test animals or their parental generations to the antigen under investigation. Objective: The influence of dietary preexposure to soy protein on oral sensitization...article 1998
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Nijmeijer, B.A. (author), Steenvoorden, D.P.T. (author), Beijersbergen Van Henegouwen, G.M.J. (author), Roza, L. (author), Vink, A.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Topical application of N-acetylcysteine prior to UVB irradiation of BALB/c mice has previously been shown to inhibit systemic suppression of the contact hypersensitivity response. Formation of cis-urocanic acid, however, is not affected. Besides urocanic acid, UV-induced DNA damage has been held responsible for the initiation of suppression of...article 1998
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Knippels, L.M.J. (author), Penninks, A.H. (author), Spanhaak, S. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Background: Although several in vivo antigenicity assays using parenteral immunization are operational, no adequate enteral sensitization models are available to study food allergy and allergenicity of food proteins. Objective: This paper describes the development of an enteral model for food allergy research in the Brown Norway (BN) rat....article 1998