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Verhoeckx, K.C.M. (author), van Broekhoven, S. (author), den Hartog-Jager, C.F. (author), Gaspari, M. (author), de Jong, G.A.H. (author), Wichers, H.J. (author), van Hoffen, E. (author), Houben, G.F. (author), Knulst, A.C. (author)Scope: Due to the imminent growth of the world population, shortage of protein sources for human consumption will arise in the near future. Alternative and sustainable protein sources (e.g. insects) are being explored for the production of food and feed. In this project, the safety of Yellow mealworms (Tenebrio molitor L.) for human consumption...article 2014
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Blom, W.M. (author), Knulst, A. (author), Houben, G.F. (author)Food allergic patients average one unexpected allergic reaction per yeer. A major cause of reactions is the unintentional presence ofallergens in packaged foods as a result of cross contamination during production. Consumers encounter voluntary labeling alerts like "may contain traces of ..." which show a poor correlation with the actual...article 2014
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Klein Entink, R.H. (author), Remington, B.C. (author), Blom, W.M. (author), Rubingh, C.M. (author), Kruizinga, A.G. (author), Baumert, J.L. (author), Taylor, S.L. (author), Houben, G.F. (author)For most allergenic foods, limited availability of threshold dose information within the population restricts the advice on action levels of unintended allergenic foods which should trigger advisory labeling on packaged foods.The objective of this paper is to provide guidance for selecting an optimal sample size for threshold dosing studies for...article 2014
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Kuper, C.F. (author), Ruehl-Fehlert, C. (author), Elmore, S.A. (author), Parker, G.A. (author)Cells of the immune system are found in every organ, from the classic lymphoid organs to tissues such as liver, mucosae, and omental adipose tissue. Toxicity to the immune system may be from a direct or indirect injury to lymphoid organs. The morphological responses range from lymphocyte depletion to proliferation, and may result in an increased...bookPart 2013
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Food avoidance in children with adverse food reactions: Influence of anxiety and clinical parametersLe, T.M. (author), Zijlstra, W.T. (author), van Opstal, E.Y. (author), Knol, M.J. (author), L'Hoir, M.P. (author), Knulst, A.C. (author), Pasmans, S.G.M.A. (author)Background: Many children in the general population avoid food because of self-reported adverse food reactions (AFR). Food avoidance can have negative consequences for well-being and nutritional status. This study aimed to investigate which factors are related to avoidance behavior in children (10-13 yr old) from the general population. Methods:...article 2013
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Masthoff, L.J. (author), Hoff, R. (author), Verhoeckx, K.C.M. (author), van Os-Medendorp, H. (author), Michelsen-Huisman, A. (author), Baumert, J.L. (author), Pasmans, S.G. (author), Meijer, Y. (author), Knulst, A.C. (author)Background Allergenicity of foods can be influenced by processing. Tree nuts are an important source of nutrition and increasingly consumed; however, processing methods are quite variable and data are currently lacking on the effects of processing on allergenicity. Objective To perform a systematic literature review on the effects of food...article 2013
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- Bousquet, J. (author), Anto, J. (author), Sunyer, J. (author), Nieuwenhuijsen, M. (author), Vrijheid, M. (author), Keil, T. (author) article 2013
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Madsen, C.B. (author), Houben, G. (author), Hattersley, S. (author), Crevel, R.W.R. (author), Remington, B.C. (author), Baumert, J.L. (author)Regulatory thresholds for allergenic foods have not yet been developed. This means that public and industrial risk managers do not have regulatory thresholds to decide if a content or level of contamination is acceptable or not. For a long time, data have been inadequate to define safe thresholds for food allergens. More and more challenge data...bookPart 2013
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van Esch, B.C.A.M. (author), van Bilsen, J.H.M. (author), Jeurink, P.V. (author), Garssen, J. (author), Penninks, A.H. (author), Smit, J.J. (author), Pieters, R.H.H. (author), Knippels, L.M.J. (author)This study describes two phases of a multi-phase project aiming to validate a mouse model for cow's milk allergy to assess the potential allergenicity of hydrolysed cow's milk based infant formulas (claim support EC-directive 2006/141/E). The transferability and the discriminatory power of this model was evaluated in 4 research centers. Mice...article 2013
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Dambacher, W.M. (author), de Kort, E.H.M. (author), Blom, W.M. (author), Houben, G.F. (author), de Vries, E. (author)Background: Children with cow's milk allergy (CMA) need a cow's milk protein (CMP) free diet to prevent allergic reactions. For this, reliable allergy-information on the label of food products is essential to avoid products containing the allergen. On the other hand, both overzealous labeling and misdiagnosis that result in unnecessary...article 2013
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Michelsen-Huisman, A.D. (author), van Os-Medendorp, H. (author), Versluis, A. (author), Kruizinga, A.G. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Houben, G.F. (author), Knulst, A.C. (author)Unexpected reactions occur in patients with food allergy, but frequency data are scare. This prospective study investigates the frequency, severity and causes of unexpected allergic reactions to food in adults with a doctor's diagnosed food allergy. Participants complete an online questionnaire after every unexpected reaction and send in the...article 2013
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Jacobs, J.H. (author), Fuertes, E. (author), Krop, E.J.M. (author), Spithoven, J. (author), Tromp, P. (author), Heederik, D.J.J. (author)Objectives: To describe associations among swimming, respiratory health, allergen sensitisation and Clara cell protein 16 (CC16) levels in Dutch schoolchildren. Trichloramine levels in swimming pool air were determined to assess potential exposure levels. Methods: Respiratory health and pool attendance information was collected from 2359...article 2012
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van Bilsen, J.H.M. (author), Ronsmans, S. (author), Crevel, R.W.R. (author), Rona, R.J. (author), Przyrembel, H. (author), Penninks, A.H. (author), Contor, L. (author), Houben, G.F. (author)Identification of allergenic foods of public health importance should be based on well-defined criteria. Björkstén et al. (2008) proposed that the criteria should assess the evidence for an IgE mechanism, the reaction, the potency and the severity of the effect of the food and its prevalence. This study evaluated the application of the proposed...article 2011
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Meijster, T. (author), Warren, N. (author), Heederik, D. (author), Tielemans, E. (author)Rationale: Insight into the effectiveness of intervention strategies will help realise a decrease in the occupational disease burden from (allergic) respiratory diseases in the bakery population. Objectives: To use a simulation model to assess the impact of different intervention strategies on the disease burden of the bakery population over...article 2011
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van Triel, J.J. (author), van Bree, B.W.J. (author), Roberts, D.W. (author), Muijser, H. (author), Duistermaat, E. (author), Woutersen, R.A. (author), Kuper, C.F. (author)Previously, a selection of low molecular weight contact and respiratory allergens had tested positive in both a skin and a respiratory local lymph node assay (LLNA), but formaldehyde was negative for sensitization by inhalation. To investigate whether this was due to intrinsic properties of aldehyde sensitizers, the structurally related allergen...article 2011
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van Triel, J.J. (author), Arts, J.H. (author), Muijser, H. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)Previously, the contact allergen dinitrochlorobenzene (DNCB) was identified as a sensitizer by inhalation in BALB/c mice; in addition, DNCB induced a lymphocytic infiltrate in the larynx of dermally sensitized Th1-prone Wistar rats upon a single inhalation challenge. In the present study, repeated inhalation exposures to DNCB were investigated...article 2010
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Arts, J.H.E. (author), Jacobs, E.J. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, it was studied whether airway irritation by sulfur dioxide (SO<sub>2</sub>) would enhance respiratory allergic reactions to trimellitic anhydride (TMA), using a rat model. Brown Norway (BN) rats were topically...article 2010
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Meijster, T. (author), Tielemans, E. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Introduction: We evaluated the effect on exposure of an intervention programme, which focused on risk education and providing information on good work practices. This intervention programme was enrolled as part of a Dutch covenant in the flour processing industry (industrial bakeries, flour mills, ingredient producers). Methods: Data from...article 2009
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Peeters, K.A.B.M. (author), Koppelman, S.J. (author), Penninks, A.H. (author), Lebens, A. (author), Bruijnzeel-Koomen, C.A.F.M. (author), Hefle, S.L. (author), Taylor, S.L. (author), van Hoffen, E. (author), Knulst, A.C. (author), TNO Kwaliteit van Leven (author)Background: The use of lupine in food has been increasing during the last decade and allergic reactions to lupine have been reported, especially in peanut-allergic patients. The frequency and the degree of cross-reactivity to other legumes are not known. The aim of the study was to investigate the frequency of sensitization to lupine, and in...article 2009
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Taylor, S.L. (author), Gendel, S.M. (author), Houben, G.F. (author), Julien, E. (author), TNO Kwaliteit van Leven (author)Food allergies are caused by immunological reactions in individuals sensitized to normal protein components of foods. For any given sensitized individual, the severity of a reaction is generally assumed to be proportional to the dose of allergenic protein. There is substantial clinical evidence that threshold doses exist for the elicitation of...article 2009