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Blom, W.M. (author), Michelsen-Huisman, A.D. (author), van Os-Medendorp, H. (author), van Duijn, G. (author), de Zeeuw-Brouwer, M.L. (author), Versluis, A. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Kruizinga, A.G. (author), Knulst, A.C. (author), Houben, G.F. (author)Background: Accidental allergic reactions to food are frequent and can be severe and even fatal. Objective: We sought to analyze the culprit food products and levels of unexpected allergens in accidental reactions. Methods: A prospective cohort study was conducted in adults (n = 157) with a physician-confirmed diagnosis of food allergy. During a...article 2018
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Birot, S. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Crépet, A. (author), Christensen, T. (author), Brockhoff, P.B. (author)To prevent allergic reactions, food producers have to be able to make a knowledge based decision on whether to label their products with precautionary labelling. As many manufactured food products are sold in different countries across Europe, the allergen risk assessment should be estimated at the European levels. As currently, there are no pan...article 2018
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Michelsen-Huisman, A.D. (author), van Os-Medendorp, H. (author), Blom, W.M. (author), Versluis, A. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Kruizinga, A.G. (author), Houben, G.F. (author), Knulst, A.C. (author)[No abstract available]article 2018
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Remington, B.C. (author), Krone, T. (author), Koppelman, S.J. (author)Background: The clinical relevance of increasing an allergic individual's peanut sensitivity threshold by immunotherapy, that is, eliciting dose (ED) to 300 or 1000 mg peanut protein, has not been previously characterized in a European population. In this study, we quantify the clinical benefits of an increased threshold of reaction following...article 2018
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Remington, B. (author), Broekman, H.C.H. (author), Blom, W.M. (author), Capt, A. (author), Crevel, R.W.R. (author), Dimitrov, I. (author), Faeste, C.K. (author), Fernandez-Canton, R. (author), Giavi, S. (author), Houben, G.F. (author), Glenn, K.C. (author), Madsen, C.B. (author), Kruizinga, A.K. (author), Constable, A. (author)The development and introduction of new dietary protein sources has the potential to improve food supply sustainability. Understanding the potential allergenicity of these new or modified proteins is crucial to ensure protection of public health. Exposure to new proteins may result in de novo sensitization, with or without clinical allergy, or...article 2018
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Fieten, K.B. (author), Totté, J.E.E. (author), Levin, E. (author), Reyman, M. (author), Meijer, Y. (author), Schuren, F.H.J. (author), Pasmans, S.G.M.A. (author), Pasmans, S.G.M.A. (author)Background: Exposure to microbes may be important in the development of atopic disease. Atopic diseases have been associated with specific characteristics of the intestinal microbiome. The link between intestinal microbiota and food allergy has rarely been studied, and the gold standard for diagnosing food allergy (double-blind placebo...article 2018
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Blankestijn, M.A. (author), den Hartog Jager, C.F. (author), Blom, W.M. (author), Otten, H.G. (author), de Jong, G.A.H. (author), Gaspari, M. (author), Houben, G.F. (author), Knulst, A.C. (author), Verhoeckx, K.C.M. (author)Background: The role of sensitization to commercially available allergens of English walnut (Juglans regia) Jug r 1, 2 and 3 in walnut allergy has been previously investigated in walnut allergic adults and was unable to explain all cases of walnut allergy. Objectives: Identify recognized walnut allergens, other than the ones previously...article 2018
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Mazzucchelli, G. (author), Holzhauser, T. (author), Cirkovic Velickovic, T. (author), Diaz-Perales, A. (author), Molina, E. (author), Roncada, P. (author), Rodrigues, P. (author), Verhoeckx, K. (author), Hoffmann-Sommergruber, K. (author)Food allergies are recognized as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well-known foods and foods containing genetically modified ingredients is installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods,...article 2018
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Smits, M. (author), Le, T.M. (author), Welsing, P. (author), Houben, G. (author), Knulst, A. (author), Verhoeckx, K. (author)Sensitization and allergy to legumes can be influenced by different factors, such as exposure, geographical background, and food processing. Sensitization and the allergic response to legumes differs considerably, however, the reason behind this is not yet fully understood. The aim of this study is to investigate if there is a correlation...article 2018
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Masthoff, L.J.N. (author), Blom, W.M. (author), Rubingh, C.M. (author), Klemans, R.J.B. (author), Remington, B.C. (author), Bruijnzeel-Koomen, C.A.F.M. (author), van Hoffen, E. (author), Houben, G.F. (author), Meyer, Y. (author), Pasmans, S.G.M.A. (author), Knulst, A.C. (author)[No abstract available] Chemicals / CAS immunoglobulin E, 37341-29-0; Allergens; Antigens, Plant; Cor a 14 allergen, hazelnut; Cor a 9 protein, hazelnut; Immunoglobulin E; Plant Proteins.article 2018
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Birot, S. (author), Madsen, C.B. (author), Kruizinga, A.G. (author), Christensen, T. (author), Crépet, A. (author), Brockhoff, P.B. (author)Food allergic subjects need to avoid the allergenic food that triggers their allergy. However, foods can also contain unintended allergens. Food manufacturers or authorities need to perform a risk assessment to be able to decide if unintended allergen presence constitutes a risk to food allergic consumers. One of the input parameters in risk...article 2017
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Broekman, H.C.H.P. (author), Knulst, A.C. (author), de Jong, G. (author), Gaspari, M. (author), den Hartog Jager, C.F. (author), Houben, G.F. (author), Verhoeckx, K.C.M. (author)Scope: The growing world population is a key driver for the exploration of sustainable protein sources to ensure food security. Mealworm and other insects are promising candidates. Previously we found that shrimp allergic patients are at risk for mealworm allergy, and that mealworm can induce a primary allergy. This study set out to investigate...article 2017
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Blom, W.M. (author), Kruizinga, A.G. (author), Rubingh, C.M. (author), Remington, B.C. (author), Crevel, R.W.R. (author), Houben, G.F. (author)Refined vegetable oils including refined peanut oil are widely used in foods. Due to shared production processes, refined non-peanut vegetable oils can contain residual peanut proteins. We estimated the predicted number of allergic reactions to residual peanut proteins using probabilistic risk assessment applied to several scenarios involving...article 2017
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van Bilsen, J.H.M. (author), Sienkiewicz-Szłapka, E. (author), Lozano-Ojalvo, D. (author), Willemsen, L.E.M. (author), Antunes, C.M. (author), Molina, E. (author), Smit, J.J. (author), Wróblewska, B. (author), Wichers, H.J. (author), Knol, E.F. (author), Ladics, G.S. (author), Pieters, R.H.H. (author), Denery-Papini, S. (author), Vissers, Y.M. (author), Bavaro, S.L. (author), Larré, C. (author), Verhoeckx, K.C.M. (author), Roggen, E.L. (author)Background: The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for...article 2017
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Grimshaw, K. (author), Logan, K. (author), O'Donovan, S. (author), Kiely, M. (author), Patient, K. (author), van Bilsen, J. (author), Beyer, K. (author), Campbell, D.E. (author), Garcia-Larsen, V. (author), Grabenhenrich, L. (author), Lack, G. (author), Mills, C. (author), Wal, J.M. (author), Roberts, G. (author)Recommendations and guidelines on the prevention of food allergy have changed in recent decades. The aim of this review of the current evidence and ongoing studies is to provide a comprehensive and up to date picture of prevention of food allergy for healthcare professionals. The review was undertaken as part of the European Union funded...article 2017
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- Remington, B.C. (author) conference paper 2017
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Ruehl-Fehlert, C. (author), Parker, G.A. (author), Elmore, S.A. (author), Kuper, C.F. (author)Cells of the immune system are found in every organ, from the classic lymphoid organs to tissues such as liver, mucosae, and omental adipose tissue. Toxicity to the immune system may be from a direct or indirect injury to lymphoid organs. The morphological responses range from lymphocyte depletion to proliferation, and may result in an increased...bookPart 2017
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Remington, B.C. (author), Westerhout, J. (author), Campbell, D.E. (author), Turner, P.J. (author)We analyzed reaction threshold data from 352 children undergoing open food challenges to hen's egg or cow's milk, either fresh or extensively heated into a muffin. There was no significant shift in dose-distribution curves due to the baking process, implying that existing threshold data for these allergens can be applied to allergen risk...article 2017
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TNO Kwaliteit van Leven (author), Blankestijn, M.A. (author), Blom, W.M. (author), Otten, H.G. (author), Baumert, J.L. (author), Taylor, S.L. (author), Bruijnzeel-Koomen, C.A.F.M. (author), Houben, G.F. (author), Knulst, A.C. (author), Klemans, R.J.B. (author)Chemicals / CAS immunoglobulin E, 37341-29-0; Allergens; Immunoglobulin E; Plant Extracts; Plant Proteinsarticle 2017
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TNO Kwaliteit van Leven (author), Blankestijn, M.A. (author), Remington, B.C. (author), Houben, G.F. (author), Baumert, J.L. (author), Knulst, A.C. (author), Blom, W.M. (author), Klemans, R.J.B. (author), Taylor, S.L. (author)Background In food allergy, eliciting doses (EDs) of foods on a population level can improve risk management and labeling strategies for the food industry and regulatory authorities. Previously, data available for walnut were unsuitable to determine EDs. Objective The objective of this study was to determine EDs for walnut allergic adults and to...article 2017