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Linders, Y.F.M. (author), Lentz, L.R. (author), Blom, W.M. (author), Michelsen-Huisman, A. (author), Strikwerda, J. (author), van Dijk, L.M. (author), Knulst, A.C. (author), Houben, G.F. (author), van Os-Medendorp, H. (author), Holleman, B.C. (author)While there are EU laws for priority allergenic ingredients information on food product packaging, there is no legislation about Precautionary Allergen Labelling (PAL) for unintended allergen presence (UAP). As a result, PAL is used in different ways by different manufacturers and retailers, which hampers consumers’ interpretation of the...article 2023
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Katz, Y. (author), Melchior, M. (author), Elizur, A. (author), Nachshon, L. (author), Remington, B.C. (author), Leshno, M. (author)Background: The safe consumption of foods depends on their allergen content in relation to patients’ lowest observed adverse effect level (LOAEL) and no observed adverse effect level (NOAEL), as well as other factors. In the case of milk, data on LOAEL and NOAEL are limited and conflicting. Objective: To determine the threshold dose distribution...article 2023
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Co-sensitization between legumes is frequently seen, but variable and not always clinically relevantSmits, M. (author), Verhoeckx, K. (author), Knulst, A. (author), Welsing, P. (author), de Jong, A. (author), Gaspari, M. (author), Ehlers, A. (author), Verhoeff, P. (author), Houben, G. (author), Le, T.M. (author)Background: Food allergy to peanut and soybean, both legumes, is highly prevalent. The consumption of other legumes and legume protein isolates, some of which may be considered novel foods, is increasing. This may lead to an increase in sensitization and allergy and may pose a risk for legume-allergic (e.g. peanut and soybean) patients due to...article 2023
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Blom, W.M. (author), Westerhout, J. (author), Houben, G.F. (author)Lack of guidance regarding selection of food intake values for allergen risk assessment can lead to different outcomes for similar levels of allergens in food products. Several food consumption survey databases (United States, North-West Europe, and Netherlands) were analyzed to identify optimal food intake percentiles using a sensitivity...article 2023
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Blom, W.M. (author), Westerhout, J. (author), Houben, G.F. (author)The need for region-specific food intake values to accurately estimate food allergen risk is underscored by the recent Ad Hoc Joint Food and Agriculture Organization/World Health Organization (FAO/WHO) Expert Consultation on Risk Assessment of Food Allergens (1). A recent study published by Sun et al. in China CDC Weekly 2022, titled A Chinese...article 2023
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Turner, P.J. (author), Patel, N. (author), Campbell, D.E. (author), Sampson, H.A. (author), Maeda, M. (author), Katsunuma, T. (author), Westerhout, J. (author), Blom, W.M. (author), Baumert, J.L. (author), Houben, G.F. (author), Remington, B.C. (author)Background: Cow's milk (CM) is an increasingly common cause of severe allergic reactions, but there is uncertainty with respect to severity of reactions at low-level CM exposure, as well as the reproducibility of reaction thresholds. Objective: We undertook an individual participant data (IPD) meta-analysis of studies reporting double-blind,...article 2022
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Houben, G.F. (author), Blom, W.M. (author), Meijerink, M. (author)Food allergy has been recognized already in early history as a condition triggered in some individuals upon consumptions of specific foods. However, its recognition as an essential element to be addressed in food safety management is of much more recent date. As a consequence, risk assessment and risk management practices for food allergy are...bookPart 2022
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Blom, W.M. (author), Westerhout, J. (author), Baumert, J.L. (author), Meima, M.Y. (author), Turner, P.J. (author), Ebisawa, M. (author), Yanagida, N. (author), Remington, B.C. (author), Houben, G.F. (author)Access to Eliciting Doses (ED) for allergens enables advanced food allergen risk assessment. Previously, the full ED range for 14 allergenic foods, including milk, and recommendations for their use were provided (Houben et al., 2020). Additional food challenge studies with cow's milk-allergic patients added 247 data points to the original...article 2022
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- Turner, P.J. (author), Baumert, J.L. (author), Beyer, K. (author), Brooke-Taylor, S. (author), Comberiati, P. (author), Crevel, R.W.R. (author), Gerdts, J.D. (author), Hazel G.M., (author), Houben, G.F. (author), Hourihane, J.O'B (author), Konstantinou, G.N. (author), La Vieille, S. (author), Moya, B. (author), Muraro, A. (author), Mills, E.N.C. (author), Patel, N. (author), Podestà, M. (author), Popping, B. (author), Reese, I. (author), Roberts, G. (author), Said, M. (author), Santos, A.F. (author), Schnadt, S. (author), Taylor, S.L. (author), Vlieg-Boerstra, B. (author), Remington, B.C. (author) article 2022
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Remington, B.C. (author), Baumert, J. (author), Blom, W.M. (author), Bucchini, L. (author), Buck, N. (author), Crevel, R. (author), de Mooij, F. (author), Flanagan, S. (author), Hindley, J. (author), Javed, B. (author), Stavropoulou, D.A. (author), van den Dungen, M.W. (author), van Ravenhorst, M. (author), Wang, S. (author), Walker, M. (author)Quantitative risk assessment (QRA) for allergens exists in many different forms with different requirements placed on the risk assessor depending on the question that needs to be answered. An electronic workshop held in October 2020 and comprising representatives from a wide range of food allergy and allergen stakeholder groups identified that a...article 2022
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Turner, P.J. (author), Patel, N. (author), Ballmer-Weber, B.K. (author), Baumert, J.L. (author), Blom, W.M. (author), Brooke-Taylor, S. (author), Brough, H. (author), Campbell, D.E. (author), Chen, H. (author), Chinthrajah, R.S. (author), Crevel, R.W.R. (author), Dubois, A.E.J. (author), Ebisawa, M. (author), Elizur, A. (author), Gerdts, J.D. (author), Gowland, M.H. (author), Houben, G.F. (author), Hourihane, J.O.B. (author), Knulst, A.C. (author), La Vieille, S. (author), López, M.C. (author), Mills, E.N.C. (author), Polenta, G.A. (author), Purington, N. (author), Said, M. (author), Sampson, H.A. (author), Schnadt, S. (author), Södergren E., (author), Taylor, S.L. (author), Remington, B.C. (author)Regional and national legislation mandates the disclosure of “priority” allergens when present as an ingredient in foods, but this does not extend to the unintended presence of allergens due to shared production facilities. This has resulted in a proliferation of precautionary allergen (“may contain”) labels (PAL) that are frequently ignored by...article 2022
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Remington, B. (author), Baumert, J. (author), Blom, W.M. (author), Bucchini, L. (author), Buck, N. (author), Crevel, R. (author), de Mooij, F. (author), Flanagan, S. (author), Stavropoulou, A. (author), van den Dungen, M. (author), van Ravenhorst, M. (author), Walker, M. (author), Wang, S. (author)Allergen cross-contact and unintended allergen presence (UAP) are a significant challenge for food operators. The aim of this document is to translate the findings of the Expert Group on ‘Food Allergen Quantitative Risk Assessment (QRA)’ into a Guidance document which provides tools and approaches to help harmonize the data gathering process for...report 2022
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- Meima, M.Y. (author), Blom, W.M. (author), Westerhout, J. (author), Kruizinga, A.G. (author), Remington, B.C. (author), Wheeler, M.W. (author), Houben, G.F. (author) article 2021
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Meima, M.Y. (author), Remington, B.C. (author), Blom, W.M. (author), Baumert, J.L. (author), Taylor, S.L. (author), Jeffery, B. (author), Robert, M.C. (author), Houben, G.F. (author), Lucas Luijckx, N.B. (author)Allergenic food particles (typically ~0.5–5 mm) may unintentionally end up in food products during production and can pose a risk for the allergic consumer. A single particle can provoke allergic symptoms in an allergic consumer when the dose of allergenic protein exceeds minimal eliciting doses. However, there is a lack of fundamental knowledge...article 2021
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Remington, B.C. (author), Westerhout, J. (author), Dubois, A.E.J. (author), Blom, W.M. (author), Kruizinga, A.G. (author), Taylor, S.L. (author), Houben, G.F. (author), Baumert, J.L. (author)Food allergen threshold dose distributions are used in food allergen risk assessment to determine the level of risk within a food-allergic population to a defined exposure amount of allergenic food protein and to help inform allergen risk management decisions. There has been a long-standing interest in determining threshold dose distributions...article 2021
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Taylor, S.L. (author), Houben, G.F. (author), Blom, W.M. (author), Westerhout, J. (author), Remington, B.C. (author), Crevel, R.W.R. (author), Brooke-Taylor, S. (author), Baumert, J.L. (author)Background. Soy is globally recognized as a commonly allergenic food. The VITAL (Voluntary Incidental Trace Allergen Labeling) Scientific Expert Panel (VSEP) of the Allergen Bureau of Australia & New Zealand used data on minimal reactive doses in low-dose clinical challenges of soy-allergic individuals to elaborate and propose the first...article 2021
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Smits, M. (author), Verhoeckx, K. (author), Knulst, A. (author), Welsing, P. (author), de Jong, A. (author), Houben, G.F. (author), Le, T.M. (author)Predicting the allergenicity of novel proteins is challenging due to the absence of validated predictive methods and a well-defined reference set of proteins. The prevalence of sensitization could be a parameter to select reference proteins to characterize allergenic proteins. This study investigated whether the prevalence of sensitization of...article 2021
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Are you concerned about allergenic proteins in food products that your company produces or provides? TNO offers a solid research and expertise base that we commit to developing practical solutions for food business operators. By quantification of allergen risks and support in allergen management, we help you to deliver safe products for allergic...other 2021
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Smits, M. (author), Nooijen, I. (author), Redegeld, F. (author), de Jong, A. (author), Le, T.M. (author), Knulst, A. (author), Houben, G.F. (author), Verhoeckc, K.C.M. (author)Scope: No accepted and validated methods are currently available which can accurately predict protein allergenicity. In this study, the role of digestion and transport on protein allergenicity is investigated. Methods and results: Peanut allergens (Ara h 1, 2, 3, and 6) and a milk allergen (β-lactoglobulin) are transported across pig intestinal...article 2021
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Smits, M. (author), Meijerink, M. (author), Le, T.M. (author), Knulst, A. (author), de Jong, A. (author), Caspers, M.P.M. (author), Lima, E.S. (author), Babe, L. (author), Ladics, G. (author), McClain, S. (author), Houben, G.F. (author), Verhoeckx, K. (author)Background: Food proteins differ in their allergenic potential. Currently, there is no predictive and validated bio-assay to evaluate the allergenicity of novel food proteins. The objective of this study was to investigate the potential of a human peripheral blood mononuclear cell (PBMC) gene expression assay to identify biomarkers to predict...article 2021