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Ponsen, L. (author), Jonkman, E.J. (author), TNO Res. Unit Clin. Neurophysiol., c/o Westeinde Hosp., 2512 VA The Hague, Netherlands Medisch Biologisch Laboratorium TNO (author)Part I of this article reviewed aetiological and clinical phenomena related to the Creutzfeldt-Jakob disease. A case history of one patient was presented together with some electro-encephalographic aspects in relation to this disease and results of computer analysis of the EEG. The slow virus concept and its implications for treatment of...article 1981
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Nooijen, W.J. (author), Koppert, P.W. (author), Gaubius instituut TNO (author)A specific glucagon antiserum was generated in rabbits using a derivatisation of the methionine residue in glucagon. A sensitive and specific assay for glucagon has been developed. Interference with the assay system by plasma factors was abolished by both extraction of plasma samples and the production of glucagon-free plasma for each individual...article 1981
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Wolthuis, O. (author), Vanwersch, R.A.P. (author), van der Wiel, H.J. (author), Medisch Biologisch Laboratorium TNO (author)Previous results had shown that bis-pyridinium oximes, particularly HI-6 are quite effective therapeutically in soman-poisoned rats and mice in vivo and in the rat diaphragm preparation in vitro. The aim of the present study was to investigate the efficacy of bis-pyridinium oximes on soman-inhibited neuromuscular transmission in muscle...article 1981
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Gaubius Instituut TNO (author), Havekes, L. (author), Vermeer, B.J. (author), Brugman, T. (author), Emeis, J. (author)Chemicals/CAS: Lipoprotein(a); Lipoproteins; Lipoproteins, LDL; Receptors, Cell Surface; Receptors, LDLarticle 1981
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Kruisbeek, A.M. (author), Steinmeier, F.A. (author), Instituut voor experimentele gerontologie TNO (author)Much data support the notion that with increasing age a decline in T cell effector function occurs. In the present study, qualitative rather than quantitative age-related changes in vitro alloreactive cytotoxic T lymphocyte (CTL) responses were observed. The level of specific alloreactive CTL responses was not consistently lower in aged mice,...article 1980
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Meihuizen, S.P. (author), Blansjaar, N. (author), Instituut voor experimentele gerontologie TNO (author)Hepatocyte morphology of the three zones of the liver lobule was evaluated by stereological analysis in 3-month-old and 35-month-old virgin female WAG/Rij rats. In the old rats, the volume of the nucleus and cytoplasm, and volume densities of smooth endoplasmic reticulum and lysosomes were increased in all areas of the liver lobule, while the...article 1980
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de Koning-Verest, I.F. (author), Medisch Biologisch Laboratorium TNO (author)The metabolism of glutamate, taken as an index of the metabolic state of the brain, was studied in brains of 3-, 12- and 30-month-old rats. Following the injection of a mixture of [3H]acetate and d-[2-14C]glucose, the brain levels of glutamate and aspartate were decreased in 30-month-old rats when compared with those of 3-month-old rats. No...article 1980
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Radl, J. (author), de Glopper, E. (author), van den Berg, P. (author), van Zwieten, M.J. (author), Instituut voor experimentele gerontologie TNO (author)The influence of thymectomy on the appearance of idiopathic paraproteinemia (IP) during aging was investigated in mice of the C57BL/KaLwRij and CBA/BrARij strains, which under normal conditions develop IP in high and low frequency, respectively. Compared with sham-thymectomized mice, C57BL mice thymectomized at a young adult age showed a...article 1980
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Nederlands Instituut voor Praeventieve Gezondheidszorg TNO (author), Blom, J.L. (author), Barth, P.G. (author), Visser, S.L. (author)With routine techniques the flash-evoked VEPs in 11 consecutive age groups between 0-6 years, each consisting of 8 children, were measured under clinical circumstances. The children were carefully screened to fit within predetermined normal limits. The main results are: (1) The primary part, consisting of 3 components, is well discernible at...article 1980
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Radl, J. (author), de Glopper, E. (author), Schuit, H.R.E. (author), Zurcher, C. (author), Instituut voor experimentele gerontologie TNO (author)Transplantation experiments in the C57BL/KaLwRij mouse model of idiopathic paraproteinemia (IP) showed that an IP-producing clone can be further propagated in young, lethally irradiated mice and also equally as well in nonirradiated recipients by a bone marrow and/or spleen cell transfer. The latency period before the original paraprotein was...article 1979
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- Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Bowles, C.H. (author) doctoral thesis 1979
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Knook, D.L. (author), Instituut voor experimentele gerontologie TNO (author)Ageing is associated with declines in the functional capacities of several organs. General causes for the decline can be divided into: 1. intrinsic cellular causes and 2. extracellular causes, e.g., changes in blood circulation and distribution. For the first group of causes, there is evidence for a decrease in the numbers of long-lived cells in...article 1978
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Haaijman, J.J. (author), van den Borne, H.W. (author), Instituut voor experimentele gerontologie TNO (author)An inventory of the recently concluded, current and planned gerontological research in the Netherlands has been made. About 160 investigators are committed to this kind of research, on which they spend 71 man years. In terms of manpower, the most effort is spent in social gerontology (76 investigators, 29.23 man years), followed by biomedical...article 1978
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von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...article 1978
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Hollander, C.F. (author), Instituut voor experimentele gerontologie TNO (author)The main goal of experimental aging research is to understand the mechanisms of aging in order to rationally approach the health problems of the aged as well as to increase the quality of life in this phase of human existence. Animal models are needed to obtain this goal. It is outlined that the approach of biomedical research on aging should be...article 1978
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Wolthuis, O.L. (author), Kepner, L.A. (author), Medisch Biologisch Laboratorium TNO (author)The bisquarternary mono-oxime HI-6, and to a lesser extent HS-6, caused functional recovery of neuromuscular transmission in vivo and in vitro when given 60 min after soman, i.e. when the soman-cholinesterase (AChE) complex is said to be fully 'aged'. Atropinised rats, with the tracheas intubated, received 4 x LD50 soman i.v. and were kept alive...article 1978
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Instituut voor experimentele gerontologie TNO (author), Blankwater, M.J. (author)A review of the present knowledge of the effect of age on the humoral immune response of mice is presented. It is shown that the capacity to mount an antibody response decreases with age, especially when the immune system is challenged for the first time by low doses of antigen, and when T cells are required for the response. Literature data are...article 1978
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- Jonkman, E.J. (author), Mosmans, P.C.M. (author) other 1977
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Instituut voor experimentele gerontologie TNO (author), Kruisbeek, A.M. (author)Age related changes in lipopolysaccharide (LPS) and concanavalin A (ConA) responsiveness of rat spleen lymphocytes as judged by 14C TdR incorporation were studied. It was found that responses to both mitogens decreased with advancing age. This report shows that the reduced 14C TdR incorporation could not be attributed to decreased cell survival...article 1976
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- Gezondheidsorganisatie TNO Werkgroep bejaardenonderzoek TNO (author), Beek, A. (author), van Zonneveld, R.J. (author) report 1975