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Fluitman, K.S. (author), Wijdeveld, M. (author), Davids, M. (author), van Ruiten, C.C. (author), Reinders, I. (author), Wijnhoven, H.A.H. (author), Keijser, B.J.F. (author), Visser, M. (author), Nieuwdorp, M. (author), IJzerman, R.G. (author)Expert groups argue to raise the recommended daily allowance for protein in older adults from 0.8 to 1.2 g/kg/day to prevent undernutrition. However, protein is thought to increase satiety, possibly through effects on gut microbiota and central appetite regulation. If true, raising daily protein intake may work counterproductively. In a...article 2023
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Vreeken, D. (author), Seidel, F. (author), de La Roij, G. (author), Vening, W. (author), den Hengst, W.A. (author), Verschuren, L. (author), Özsezen, S. (author), Kessels, R.P.C. (author), Duering, M. (author), Mutsaerts, H.J.M.M. (author), Kleemann, R. (author), Wiesmann, M. (author), Hazebroek, E.J. (author), Kiliaan, A.J. (author)BACKGROUND AND OBJECTIVE: While underlying pathophysiology linking obesity to brain health is not completely understood, white adipose tissue (WAT) is considered a key player. In obesity, WAT becomes dysregulated, showing hyperplasia, hypertrophy, and eventually inflammation. This disbalance leads to dysregulated secretion of adipokines...article 2023
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Schuller, A.A. (author), Hoekstra, A.R. (author)Aims. With increasing age, the proportion of older individuals visiting a dental clinic decreases. The aim was to gain insight into a) whether frailty or dental status were associated with visiting a dental clinic and b) their perceived barriers to accessing oral health care. Methods. Individuals eligible for the yearly influenza vaccination in...article 2023
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Vreeken, D. (author), Seidel, F. (author), Custers, E.M. (author), Olsthoorn, L. (author), Cools, S. (author), Aarts, E.O. (author), Kleemann, R. (author), Kessels, R. (author), Weismann, M. (author), Hazebroek, E.J. (author), Killiaan, A.J. (author)Importance: Bariatric surgery-induced weight loss is often associated with improved cognitive function. However, improvement in cognitive function is not always exhibited by all patients, and the mechanisms behind cognitive improvement remain unknown. Objective: To investigate the association of changes in adipokines, inflammatory factors, mood,...article 2023
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de Jong, J.C.B.C. (author), Attema, B.J. (author), van der Hoek, M.D. (author), Verschuren, L. (author), Caspers, M.P.M. (author), Kleemann, R. (author), van der Leij, F.R. (author), van den Hoek, A.M. (author), Nieuwenhuizen, A.G. (author), Keijer, J. (author)The prevalence of sarcopenia is increasing while it is often challenging, expensive and time-consuming to test the effectiveness of interventions against sarcopenia. Translational mouse models that adequately mimic underlying physiological pathways could accelerate research but are scarce. Here, we investigated the translational value of three...article 2023
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Seidel, F. (author), Fluiter, K. (author), Kleemann, R. (author), Worms, N. (author), van Nieuwkoop, A. (author), Caspers, M.P.M. (author), Grigoriadis, N. (author), Kiliaan, A.J. (author), Baas, F. (author), Michailidou, I. (author), Morrison, M.C. (author)Introduction: Obesity has been linked to vascular dysfunction, cognitive impairment and neurodegenerative diseases. However, experimental models that recapitulate brain pathology in relation to obesity and vascular dysfunction are still lacking. Methods: In this study we performed the histological and histochemical characterization of brains...article 2023
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Seidel, F. (author), Fluiter, K. (author), Kleemann, R. (author), Worms, N. (author), van Nieuwkoop, A. (author), Caspers, M.P.M. (author), Grigoriadis, N. (author), Kiliaan, A.J. (author), Baas, F. (author), Michailidou, I. (author), Morrison, M.C. (author)[This corrects the article DOI: 10.3389/fncel.2023.1205261.]article 2023
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de Jong, J.C.B.C. (author), Verschuren, L. (author), Caspers, M.P.M. (author), van der Hoek, M.D. (author), van der Leij, F.R. (author), Kleemann, R. (author), van den Hoek, A.M. (author), Nieuwenhuizen, A.G. (author), Keijer, J. (author)Background: Physical weakness is a key component of frailty, and is highly prevalent in older adults. While females have a higher prevalence and earlier onset, sex differences in the development of frailty-related physical weakness are hardly studied. Therefore, we investigated the intramuscular changes that differentiate between fit and weak...article 2023
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Hamzah, N. (author), Höjer Holmgren, K. (author), Åstot, C. (author), van der Schans, M.J. (author), de Reuver, L.P.J. (author), Vanninen, P. (author)The formation of chlorinated organic compounds in concrete debris exposed to reactive chlorine was studied to search for markers specific to chlorine gas exposure. Concrete materials of different origins were exposed to a range of species of reactive chlorine including bleach, humid and dry chlorine gas at different concentrations. Chlorinated...article 2023
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Pak, K. (author), Kooij, T.A.M. (author), de Lange, A.H. (author), van den Heuvel, S. (author), van Veldhoven, M.J.P.M. (author)In order to age successfully at work, people need to maintain or improve their work ability and motivation to work. This implies a process that develops over time and can differ substantially between individuals. This study investigated whether different trajectories of perceived work ability and motivation to work can be distinguished between...article 2023
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de Rond, V. (author), Hulzinga, F. (author), Baggen, R.J. (author), de Vries, A. (author), Orban de Xivry, J.J. (author), Pantall, A. (author), Nieuwboer, A. (author)urpose: Postural control deteriorates with age, especially under dual-task conditions. It is currently unknown how a challenging virtual reality weight-shifting task affects lower back muscle activity. Hence, this study investigated erector spinae neuromuscular control during mediolateral weight-shifting as part of an exergame during single- (ST...article 2023
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Ramsey, K.A. (author), Yeung, S.S.Y. (author), Rojer, A.G.M. (author), Gensous, N. (author), Asamane, E.A. (author), Aunger, J.A. (author), Bondarev, D. (author), Cabbia, A. (author), Doody, P. (author), Iadarola, B. (author), Rodrigues, B. (author), Tahir, M.R. (author), Kallen, V. (author), Pazienza, P. (author), Santos, N.C. (author), Sipilä, S. (author), Thompson, J.L. (author), Meskers, C.G.M. (author), rappenburg, M.C. (author), Whittaker, A.C. (author), Maier1, A.B. (author)Purpose: Evidence-based guidelines on nutrition and physical activity are used to increase knowledge in order to promote a healthy lifestyle. However, actual knowledge of guidelines is limited and whether it is associated with health outcomes is unclear. Participants and Methods: This inception cohort study aimed to investigate the association...article 2022
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Shimura, T. (author), Sato, S. (author), Zalar, P. (author), Matsuhisa, N. (author)Wearable technologies are becoming important for the fields of information technology and healthcare, driven mainly by societal issues such as the aging society and the current pandemic. Recently developed flexible/stretchable wearable devices have demonstrated their ability for long-term healthcare monitoring with improved signal integrity and...article 2022
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Streekstra, E.J. (author), Kiss, M. (author), van den Heuvel, J. (author), Nicolaï, J. (author), van den Broek, P. (author), Botden, S.M.B.I. (author), Stommel, M.W.J. (author), van Rijssel, L. (author), Ungell, A.L. (author), van de Steeg, E. (author), Russel, F.G.M. (author), de Wildt, S.N. (author)Little is known about the impact of age on the processes governing human intestinal drug absorption. The Ussing chamber is a system to study drug transport across tissue barriers, but it has not been used to study drug absorption processes in children. This study aimed to explore the feasibility of the Ussing chamber methodology to assess...article 2022
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Jong, J.C.B.C. (author), Attema, B.J. (author), van der Hoek, M.D. (author), Verschuren, L. (author), Caspers, M.P.M. (author), Kleemann, R. (author), van der Leij, F.R. (author), van den Hoek, A.M. (author), Nieuwenhuizen1, A.G. (author), Keijer, J. (author)Sex differences in muscle‐ageing are incompletely understood and could be crucial for the optimalisation of sarcopenia‐related interventions. • Therefore, we performed an observational trial to gain insight in potential sex differences in processes involved in human muscle‐ageing.public lecture 2022
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Kraaijpoel, D.A. (author), Esteves Martins, J.C. (author), Osinga, S. (author), Vogelaar, B.B.S.A. (author), Breunese, J.N. (author)We perform statistical analyses on spatiotemporal patterns in the magnitude distribution of induced earthquakes in the Groningen natural gas field. The seismic catalogue contains 336 earthquakes with (local) magnitudes above , observed in the period between 1 January 1995 and 1 January 2022. An exploratory moving-window analysis of maximum...article 2022
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van Dommelen, P. (author), Arnaud, L. (author), Koledova, E.B. (author)Curve matching may be used to predict growth outcomes using data of patients whose growth curves resemble those of a new patient with growth hormone deficiency (GHD) and those born small for gestational age (SGA). We aimed to investigate the validity of curve matching to predict growth in patients with GHD and those born SGA receiving...article 2022
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Bongers, C.C.W.G. (author), de Korte, J.Q. (author), Zwartkruis, M. (author), Levels, K. (author), Kingma, B.R.M. (author), Eijsvogels, T.M.H. (author)The combination of an exacerbated workload and impermeable nature of the personal protective equipment (PPE) worn by COVID-19 healthcare workers increases heat strain. We aimed to compare the prevalence of heat strain symptoms before (routine care without PPE) versus during the COVID-19 pandemic (COVID-19 care with PPE), identify risk factors...article 2022
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de Verhoeff, M.C. (author), Lobbezoo, F. (author), van Leeuwen, A.M. (author), Schuller, A.A. (author), Koutris, M. (author)Background: Parkinson's disease (PD) is a neurodegenerative condition affecting the quality of life. Due to a worsening of oral health in PD patients with the progression of the disease, oral health-related quality of life (OHRQoL) could be impaired as well. Objectives: To assess whether PD patients in The Netherlands experience worse OHRQoL...article 2022
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van de Ven, D. (author), Robroek, S.J.W. (author), Oude Hengel, K.M. (author), Burdorf, A. (author), Schuring, M. (author)Objectives This study aimed to evaluate the extent to which physical and mental health and body mass index (BMI) changed before, during and after becoming unemployed or employed, and whether these associations differ across psychosocial and physical working conditions. Methods Participants from seven waves (2010–2017) of the Dutch longitudinal...article 2022