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- van Wouwe, J.P. (author), Jacobusse, G. (author), van Buuren, S. (author), TNO Kwaliteit van Leven (author) article 2008
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de Beer, F. (author), Stalenhoef, A.F.H. (author), Hoogerbrugge, N. (author), Kastelein, J.J.P. (author), Leuven, J.A.G. (author), van Duijn, C.M. (author), Havekes, L.M. (author), Smelt, A.H.M. (author), Gaubius Instituut TNO (author)Type III hyperlipoproteinemia (HLP) is mainly found in homozygous carriers of apolipoprotein E2 (apoE2, Arg158→Cys). Only a small percentage (<5%) of these apoE2 homozygotes develops hyperlipidemia, indicating that additional environmental and genetic factors contribute to the expression of type III HLP. In the present study, first, the...article 2002
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van Hogeboom Buggenum, I.M. (author), Polak, B.C.P. (author), Reichert-Thoen, J.W.M. (author), Vries de - Knoppert, W.A.E.J. (author), van Hinsbergh, V.W.M. (author), Tangelder, G.J. (author), Gaubius Instituut TNO (author)Aims/hypothesis. Vascular endothelial growth factor (VEGF) is thought to be instrumental in the progression of diabetic retinopathy. Indications exist that the renin-angiotensin system is involved in VEGF overexpression. We assessed the vitreous VEGF concentrations in patients and related them to anti-hypertensive treatment, with special...article 2002
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Okma-Keulen, P. (author), Hopman-Rock, M. (author)Objective. This qualitative study aims to investigate which factors are possibly associated with the onset of generalized osteoarthritis (OA) in older women. Methods. The study population was recruited from participants of a group course, "Coping With Osteoarthritis of the Hip or Knee." Twenty-three women with generalized OA were identified, 20...article 2001
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TNO Preventie en Gezondheid (author), Boonen, A. (author), Chorus, A. (author), Miedema, H. (author), van der Heijde, D. (author), Landewe, R. (author), Schouten, H. (author), van der Tempel, H. (author), van der Linden, S. (author)Objective - To investigate withdrawal from the labour force because of inability to work owing to ankylosing spondylitis (AS) and to determine the characteristics of patients with no job because of work disability attributable to AS. Methods - A postal questionnaire was sent to 709 patients with AS aged 16-60 years followed up by a...article 2001