Searched for: subject%3A%22Administration%252C%255C%2BTopical%22
(1 - 6 of 6)
document
Nagelkerken, L. (author), Verzaal, P. (author), Lagerweij, T. (author), Persoon-Deen, C. (author), Berbee, J.F.P. (author), Prens, E.P. (author), Havekes, L.M. (author), Oranje, A.P. (author), TNO Kwaliteit van Leven (author)
Mice with transgenic expression of human apolipoprotein C1 (APOC1) in liver and skin have strongly increased serum levels of cholesterol, triglycerides, and free fatty acids, indicative of a disturbed lipid metabolism. Importantly, these mice display a disturbed skin barrier function, evident from increased transepidermal water loss, and...
article 2008
document
Nohynek, G.J. (author), Meuling, W.J.A. (author), Vaes, W.H.J. (author), Lawrence, R.S. (author), Shapiro, S. (author), Schulte, S. (author), Steiling, W. (author), Bausch, J. (author), Gerber, E. (author), Sasa, H. (author), Nau, H. (author), TNO Kwaliteit van Leven (author)
Background: Vitamin A is widely used in cosmetic preparations. Given that oral Vitamin A and its metabolites present a potential reproductive risk, the present study investigated the effect of topical Vitamin A on human endogenous plasma levels of Vitamin A and its metabolites. Methods: Two groups of 14 female volunteers of child-bearing age...
article 2006
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Nohynek, G.J. (author), Skare, J.A. (author), Meuling, W.J.A. (author), Hein, D.W. (author), de Bie, A.T.H.J. (author), Toutain, H. (author), TNO Voeding (author)
In the organism of mammals, important detoxification pathways of arylamines are catalysed by N-acetyltransferase 2 (NAT2). A recent case-control epidemiology study suggested that human NAT2 slow acetylators exposed to oxidative hair dyes may be at greater risk to develop bladder cancer. We therefore profiled urinary [14C]-metabolites and NAT2...
article 2004
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Benech-Kieffer, F. (author), Meuling, W.J.A. (author), Leclerc, C. (author), Roza, L. (author), Leclaire, J. (author), Nohynek, G. (author), TNO Voeding (author)
The potential human health risk of UV filters depends on their toxicity and the human systemic exposure which is a function of the extent of percutaneous absorption of the topically applied substance into the human organism. Using a 'mass balance' approach, a study was designed to investigate the systemically absorbed dose of [14C]-Mexoryl SX®...
article 2003
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van der Schans, M.J. (author), Lander, B.J. (author), van der Wiel, H. (author), Langenberg, J.P. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
In continuation of our investigations on the toxicokinetics of the volatile nerve agents C(±)P(±)-soman and (±)-sarin, we now report on the toxicokinetics of the rather nonvolatile agent (±)-VX. A validated method was developed to determine blood levels of (±)-VX by means of achiral gas chromatography at blood levels ≥10 pg/ml. The ratio of the...
article 2003
document
Arts, J.H.E. (author), Dröge, S.C.M. (author), Bloksma, N. (author), Kuper, C.F. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Five rat strains were compared for their performance in the local lymph node assay (LLNA) a promising test system for the identification of the skin-sensitizing potential of chemicals in the mouse. The contact sensitizer 2,4-dinitrochlorobenzene (DNCB) and the contact and respiratory sensitizer trimellitic anhydride (TMA) were used as model...
article 1996
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