Searched for: subject:"Adiposity"
(1 - 20 of 86)

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Virtanen, S.M. (author), van 't Veer, P. (author), Kok, F. (author), Kardinaal, A.F.M. (author), Aro, A. (author), EURAMIC Study Group (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective: To evaluate the levels of adipose tissue alpha-tocopherol, gamma-tocopherol, and toenail selenium and their determinants. Design: Control subjects from multicentre case-control study on antioxidants, myocardial infarction and cancer of the breast. Subjects and setting: 686 male and 339 female middle-aged and elderly subjects from...
article 1996
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Bijland, S. (author), Pieterman, E.J. (author), Maas, A.C.E. (author), van der Hoorn, J.W.A. (author), van Erk, M.J. (author), van Klinken, J.B. (author), Havekes, L.M. (author), van Dijk, K.W. (author), Princen, H.M.G. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
The peroxisome proliferator-activated receptor alpha (PPARα) activator fenofibrate efficiently decreases plasma triglycerides (TG), which is generally attributed to enhanced very low density lipoprotein (VLDL)-TG clearance and decreased VLDL-TG production. However, because data on the effect of fenofibrate on VLDL production are controversial,...
article 2010
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van Erk, M.J. (author), Pasman, W.J. (author), Wortelboer, H.M. (author), van Ommen, B. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
The goal of this study was to investigate the effect of a short-term nutritional intervention on gene expression in adipose tissue from lean and overweight subjects. Gene expression profiles were measured after consumption of an intervention spread (increased levels of polyunsaturated fatty acids, conjugated linoleic acid and medium chain...
article 2008
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Derous, D. (author), Kelder, T. (author), van Schothorst, E.M. (author), van Erk, M. (author), Voigt, A. (author), Klaus, S. (author), Keijer, J. (author), Radonjic, M. (author)
Health is influenced by interplay of molecular, physiological and environmental factors. To effectively maintain health and prevent disease, health-relevant relations need to be understood at multiple levels of biological complexity. Network-based methods provide a powerful platform for integration and mining of data and knowledge characterizing...
article 2015
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Coomans, C.P. (author), Geerling, J.J. (author), Guigas, B. (author), van den Hoek, A.M. (author), Parlevliet, E.T. (author), Ouwens, D.M. (author), Pijl, H. (author), Voshol, P.J. (author), Rensen, P.C.N. (author), Havekes, L.M. (author), Romijn, J.A. (author), Gaubius Instituut TNO (author)
Insulin signaling in the central nervous system (CNS) is required for the inhibitory effect of insulin on glucose production. Our aim was to determine whether the CNS is also involved in the stimulatory effect of circulating insulin on the tissue-specific retention of fatty acid (FA) from plasma. In wild-type mice, hyperinsulinemic-euglycemic...
article 2011
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Lu, Z.F. (author), Doulabi, B.Z. (author), Huang, C.L. (author), Bank, R.A. (author), Helder, M.N. (author), TNO Kwaliteit van Leven (author)
β1 integrins play a controversial role during chondrogenesis. Since the maturation of chondrocytes relies on a signaling switch from cell-cell to cell-matrix interactions, we hypothesized that β1 integrins play a different role at the earlier (mainly cell-cell interaction) from the later stage (mainly cell-matrix interaction) of chondrogenesis....
article 2008
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Kockx, M. (author), Leenen, R. (author), Seidell, J. (author), Princen, H.M.G. (author), Kooistra, T. (author), Gaubius instituut TNO (author)
This study was aimed at evaluating the relationship between visceral fat accumulation and plasma plasminogen activator inhibitor-1 (PAI-1) levels in healthy, obese men and women undergoing weight loss therapy. The subjects, 25 men and 25 premenopausal women, aged between 26 and 49 years, with an initial body mass index between 28 and 38 kg/m2,...
article 1999
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Blum, R. (author), Kiy, T. (author), Waalkens-Berendsen, I. (author), Wong, A.W. (author), Roberts, A. (author), TNO Kwaliteit van Leven (author)
Polyunsaturated fatty acids, including docosahexaenoic acid (DHA), are natural constituents of the human diet. DHA-algal oil is produced through the use of the marine protist, Ulkenia sp. The reproductive toxicity of DHA-algal oil was assessed in a one-generation study. Rats were provided diets containing DHA-algal oil at concentrations of 1.5,...
article 2007
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Koopmans, S.J. (author), Jong, M.C. (author), Que, I. (author), Dahlmans, V.E.H. (author), Pijl, H. (author), Radder, J.K. (author), Frölich, M. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Aims/hypothesis. Insulin resistance for glucose metabolism is associated with hyperlipidaemia and high blood pressure. In this study we investigated the effect of primary hyperlipidaemia on basal and insulin-mediated glucose and on non-esterified fatty acid (NEFA) metabolism and mean arterial pressure in hyperlipidaemic transgenic mice...
article 2001
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Pelgrim, C.E. (author), Franx, B.A.A. (author), Snabel, J. (author), Kleemann, R. (author), Arnoldussen, I.A.C. (author), Kiliaan, A.J. (author)
Adipose tissue (AT) has a modulating role in obesity-induced metabolic complications like type 2 diabetes mellitus (T2DM) via the production of so-called adipokines such as leptin, adiponectin, and resistin. The adipokines are believed to influence other tissues and to affect insulin resistance, liver function, and to increase the risk of T2DM....
article 2017
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van der Heijden, R.A. (author), Fareeba Sheedfar, F. (author), Morrison, M.C. (author), Hommelberg, P.P.H. (author), Kor1, D. (author), Kloosterhuis, N.J. (author), Gruben, N. (author), Youssef, S.A. (author), de Bruin, A. (author), Hofker, M.H. (author), Kleemann, R. (author), Koonen, D.P.Y. (author), Heeringa1, P. (author)
Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of diet-induced obesity in human and rodent studies. Although the adipose tissue and the liver are both prone to become chronically inflamed with prolonged obesity, their individual contribution to the development of metabolic inflammation remains...
article 2015
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Sweeney, R.E. (author), Langenberg, J.P. (author), Maxwell, D.M. (author), TNO Defensie en Veiligheid (author)
A physiologically based pharmacokinetic (PB/PK) model has been developed in advanced computer simulation language (ACSL) to describe blood and tissue concentration-time profiles of the C(±)P(-) stereoisomers of soman after inhalation, subcutaneous and intravenous exposures at low (0.8-1.0 × LD50), medium (2-3 × LD50) and high (6 × LD50) levels...
article 2006
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Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...
article 2017
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Boer, J.M.A. (author), Ehnholm, C. (author), Menzel, H.J. (author), Havekes, L.M. (author), Rosseneu, M. (author), O'Reilly, D.S.J. (author), Tiret, L. (author), Gaubius Instituut TNO (author)
To elucidate how the apolipoprotein (apo)E polymorphism and modifiable factors interact in explaining plasma lipid and apolipoprotein levels, we studied 1448 young adults (18 to 26 years old), participating in the European Atherosclerosis Research Study (EARS). Venous blood was collected after an overnight fast. Modifiable factors, eg, body mass...
article 1997
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Al-Lahham, S.H. (author), Roelofsen, H. (author), Priebe, M. (author), Weening, D. (author), Dijkstra, M. (author), Hoek, A. (author), Rezaee, F. (author), Venema, K. (author), Vonk, R.J. (author), TNO Kwaliteit van Leven (author)
Background Dietary fibre (DF) has been shown to be protective for the development of obesity, insulin resistance and type 2 diabetes. Short-chain fatty acids, produced by colonic fermentation of DF might mediate this beneficial effect. Adipose tissue plays a key role in the regulation of energy homeostasis, therefore, we investigated the...
article 2010
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Gómez-Aracena, J. (author), Martin-Moreno, J.M. (author), Riemersma, R.A. (author), Bode, P. (author), Gutiérrez-Bedmar, M. (author), Gorgojo, L. (author), Kark, J.D. (author), Garcia-Rodríguez, A. (author), Gomez-Gracia, E. (author), Kardinaal, A.F.M. (author), Aro, A. (author), van 't Veer, P. (author), Wedel, H. (author), Kok, F.J. (author), Fernández-Crehuet, J. (author)
The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 μg/kg in cases and 7.75 μg/kg in...
article 2002
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Sierksma, A. (author), Patel, H. (author), Ouchi, N. (author), Kihara, S. (author), Funahashi, T. (author), Heine, R.J. (author), Grobbee, D.E. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Preventie en Gezondheid (author)
OBJECTIVE - Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may...
article 2004
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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...
article 1998
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Muurling, M. (author), van den Hoek, A.M. (author), Mensink, R.P. (author), Pijl, H. (author), Romijn, J.A. (author), Havekes, L.M. (author), Voshol, P.J. (author), Gaubius Instituut TNO (author)
Obese obob mice with strong overexpression of the human apolipoprotein C1 (APOC1) exhibit excessive free fatty acid (FFA) and triglyceride (TG) levels and severely reduced body weight (due to the absence of subcutaneous adipose tissue) and skin abnormalities. To evaluate the effects of APOC1 overexpression on hepatic and peripheral insulin...
article 2004
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Al-Lahham, S. (author), Roelofsen, H. (author), Rezaee, F. (author), Weening, D. (author), Hoek, A. (author), Vonk, R. (author), Venema, K. (author)
Background Adipose tissue is a primary site of obesity-induced inflammation, which is emerging as an important contributor to obesity-related diseases such as type 2 diabetes. Dietary fibre consumption appears to be protective. Short-chain fatty acids, e.g. propionic acid, are the principal products of the colonic fermentation of dietary fibre...
article 2012
Searched for: subject:"Adiposity"
(1 - 20 of 86)

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