Searched for: subject:"Adiposity"
(61 - 80 of 86)

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Goudriaan, J.R. (author), Espirito Santo, S.M.S. (author), Voshol, P.J. (author), Teusink, B. (author), van Dijk, K.W. (author), van Vlijmen, B.J.M. (author), Romijn, J.A. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Gaubius Instituut TNO (author)
The VLDL receptor (VLDLr) is involved in tissue delivery of VLDL-triglyceride (TG)-derived FFA by facilitating the expression of lipoprotein lipase (LPL). However, vldlr-/- mice do not show altered plasma lipoprotein levels, despite reduced LPL expression. Because LPL activity is crucial in postprandial lipid metabolism, we investigated whether...
article 2004
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Mandard, S. (author), Zandbergen, F. (author), Nguan, S.T. (author), Escher, P. (author), Patsouris, D. (author), Koenig, W. (author), Kleemann, R. (author), Bakker, A. (author), Veenman, F. (author), Wahli, W. (author), Müller, M. (author), Kersten, S. (author), TNO Preventie en Gezondheid (author)
The fasting-induced adipose factor (FIAF, ANGPTL4, PGAR, HFARP) was previously identified as a novel adipocytokine that was up-regulated by fasting, by peroxisome proliferator-activated receptor agonists, and by hypoxia. To further characterize FIAF, we studied regulation of FIAF mRNA and protein in liver and adipose cell lines as well as in...
article 2004
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den Boer, M. (author), Voshol, P.J. (author), Kuipers, F. (author), Havekes, L.M. (author), Romijn, J.A. (author), TNO Preventie en Gezondheid (author)
Epidemiological studies in humans, as well as experimental studies in animal models, have shown an association between visceral obesity and dyslipidemia, insulin resistance, and type 2 diabetes mellitus. Recently, attention has been focused on the excessive accumulation of triglycerides (TG) in the liver as part of this syndrome. In this review,...
article 2004
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Ferreira, I. (author), Snijder, M.B. (author), Twisk, J.W.R. (author), van Mechelen, W. (author), Kemper, H.C.G. (author), Seidell, J.C. (author), Stehouwer, C.D.A. (author), TNO Arbeid (author)
Central and peripheral fatness seem to confer opposite (i.e. adverse vs. protective) effects on cardiovascular risk, but how this occurs is not clear. In addition, the role of peripheral lean mass needs to be elucidated. We therefore investigated, in 336 (175 women) 36-yr-old and apparently healthy adults, the relationship between trunk fat,...
article 2004
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van Marken Lichtenbelt, W. (author), Daanen, H.A.M. (author)
Purpose of review Cold response can be insulative (drop in peripheral temperature) or metabolic (increase in energy expenditure). Nonshivering thermogenesis by sympathetic, norepinephrine-induced mitochondrial heat production in brown adipose tissue is a well known component of this metabolic response in infants and several animal species. In...
article 2003
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Gómez-Aracena, J. (author), Martin-Moreno, J.M. (author), Riemersma, R.A. (author), Bode, P. (author), Gutiérrez-Bedmar, M. (author), Gorgojo, L. (author), Kark, J.D. (author), Garcia-Rodríguez, A. (author), Gomez-Gracia, E. (author), Kardinaal, A.F.M. (author), Aro, A. (author), van 't Veer, P. (author), Wedel, H. (author), Kok, F.J. (author), Fernández-Crehuet, J. (author)
The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 μg/kg in cases and 7.75 μg/kg in...
article 2002
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Berendschot, T.T.J.M. (author), Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Kardinaal, A.F.M. (author), van Poppel, G. (author), van Norren, D. (author), TNO Technische Menskunde (author)
Objective: To investigate whether nutritional factors and possible risk factors for cataract influence the lens optical density (LOD). Design: Three hundred seventy-six subjects, aged 18 to 75 years, were recruited. In a cross-sectional design, serum was analyzed for lutein, zeaxanthin, vitamin C, α-tocopherol, and cholesterol levels. Adipose...
article 2002
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Broekmans, W.M.R. (author), Berendschot, T.T.J.R. (author), Klöpping-Ketelaars, I.A.A. (author), de Vries, A.J. (author), Goldbohm, R.A. (author), Tijburg, L.B.M. (author), Kardinaal, A.F.M. (author), van Poppel, G. (author), TNO Voeding (author)
Background: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a...
article 2002
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Koopmans, S.J. (author), Jong, M.C. (author), Que, I. (author), Dahlmans, V.E.H. (author), Pijl, H. (author), Radder, J.K. (author), Frölich, M. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Aims/hypothesis. Insulin resistance for glucose metabolism is associated with hyperlipidaemia and high blood pressure. In this study we investigated the effect of primary hyperlipidaemia on basal and insulin-mediated glucose and on non-esterified fatty acid (NEFA) metabolism and mean arterial pressure in hyperlipidaemic transgenic mice...
article 2001
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Goudriaan, J.R. (author), Tacken, P.J. (author), Dahlmans, V.E.H. (author), Gijbels, M.J.J. (author), van Dijk, K.W. (author), Havekes, L.M. (author), Jong, M.C. (author), Gaubius Instituut TNO (author)
It has previously been reported that mice lacking the VLDL receptor (VLDLR-/-) exhibit normal plasma lipid levels and a modest decrease in adipose tissue mass. In the present study, the effect of VLDLR deficiency on profound weight gain was studied in mice. Obesity was induced either by feeding of a high-fat, high-calorie (HFC) diet or by...
article 2001
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), Couet, C. (author), Aro, A. (author), Kafatos, A. (author), Steingrimsdottir, L. (author), Amorim Cruz, J.A. (author), Moreiras, O. (author), Becker, W. (author), van Amelsvoort, J.M.M. (author), Vidal-Jessel, S. (author), Salminen, I. (author), Moschandreas, J. (author), Sigfússon, N. (author), Martins, I. (author), Carbajal, A. (author), Ytterfors, A. (author), van Poppel, G. (author)
Background: High intakes of trans fatty acids (TFA) have been found to exert an undersirable effect on serum lipid profiles, and thus may increase the risk for cardiovascular disease. Objective: Investigation of the association between TFA intake and serum lipids. Design: Cross-sectional study in eight European countries (Finland, France, Greece...
article 2000
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Kockx, M. (author), Leenen, R. (author), Seidell, J. (author), Princen, H.M.G. (author), Kooistra, T. (author), Gaubius instituut TNO (author)
This study was aimed at evaluating the relationship between visceral fat accumulation and plasma plasminogen activator inhibitor-1 (PAI-1) levels in healthy, obese men and women undergoing weight loss therapy. The subjects, 25 men and 25 premenopausal women, aged between 26 and 49 years, with an initial body mass index between 28 and 38 kg/m2,...
article 1999
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Guallar, E. (author), Aro, A. (author), Jiménez, F.J. (author), Martín-Moreno, J.M. (author), Salminen, I. (author), van 't Veer, P. (author), Kardinaal, A.F.M. (author), Gömez-Aracena, J. (author), Martin, B.C. (author), Kohlmeier, L. (author), Kark, J.D. (author), Mazaev, V.P. (author), Ringstad, J. (author), Guillén, J. (author), Riemersma, R.A. (author), Huttunen, J.K. (author), Thamm, M. (author), Kok, F.J. (author)
Omega-3 fatty acids have potential antiatherogenic, antithrombotic, and antiarrhythmic properties, but their role in coronary heart disease remains controversial. To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and...
article 1999
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Sanz-Gallardo, M.I. (author), Guallar, E. (author), van 't Veer, P. (author), Longnecker, M.P. (author), Strain, J.J. (author), Martin, B.C. (author), Kardinaal, A.F.M. (author), Fernández-Crehuet, J. (author), Thamm, M. (author), Kohlmeier, L. (author), Kok, F.J. (author), Martín-Moreno, J.M. (author)
To identify the determinants of p,p'-dichlorodiphenyldichloroethane (p,p'-DDE) in adipose tissue in subjects who participated in a cross- sectional study, we analyzed fatty acids, antioxidants, and p,p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 μg...
article 1999
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Yudkin, J.S. (author), Stehouwer, C.D.A. (author), Emeis, J.J. (author), Coppack, S.W. (author), Gaubius instituut TNO (author)
C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of levels of C-reactive protein and interleukin-6 with...
article 1999
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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...
article 1998
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Simonsen, N. (author), van 't Veer, P. (author), Strain, J.J. (author), Martin-Moreno, J.M. (author), Huttunen, J.K. (author), Navajas, J.F.-C. (author), Martin, B.C. (author), Thamm, M. (author), Kardinaal, A.F.M. (author), Kok, F.J. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The fatty acid content of adipose tissue in postmenopausal breast cancer cases and controls from five European countries in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Cancer (EURAMIC) breast cancer study (1991-1992) was used to explore the hypothesis that fatty acids of the omega-3 family inhibit breast...
article 1998
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Giltay, E.J. (author), Elbers, J.M.H. (author), Gooren, L.J.G. (author), Emeis, J.J. (author), Kooistra, T. (author), Asscheman, H. (author), Stehouwer, C.D.A. (author), Gaubius Instituut TNO (author)
Increased plasminogen activator inhibitor type-1 (PAI-1) levels, leading to impaired fibrinolysis, are associated with increased visceral fat in middle-aged and obese subjects. It is unknown, however, whether this association is independent of other disturbances clustered in the insulin resistance syndrome. We analyzed this association in young,...
article 1998
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Boer, J.M.A. (author), Ehnholm, C. (author), Menzel, H.J. (author), Havekes, L.M. (author), Rosseneu, M. (author), O'Reilly, D.S.J. (author), Tiret, L. (author), Gaubius Instituut TNO (author)
To elucidate how the apolipoprotein (apo)E polymorphism and modifiable factors interact in explaining plasma lipid and apolipoprotein levels, we studied 1448 young adults (18 to 26 years old), participating in the European Atherosclerosis Research Study (EARS). Venous blood was collected after an overnight fast. Modifiable factors, eg, body mass...
article 1997
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van 't Veer, P. (author), Lobbezoo, E. (author), Martín-Moreno, J.M. (author), Guallar, E. (author), Gómez-Aracena, J. (author), Kardinaal, A.F.M. (author), Kohlmeier, L. (author), Martin, B.C. (author), Strain, J.J. (author), Thamm, M. (author), van Zoonen, P. (author), Baumann, B.A. (author), Huttunen, J.K. (author), Kok, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Objective: To examine any possible links between exposure to DDE (1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene), the persistent metabolite of the pesticide dicophane DDT), and breast cancer. Design: Multicentre study of exposure to DDE by measurement of adipose tissue aspirated from the buttocks. Laboratory measurements were conducted in a...
article 1997
Searched for: subject:"Adiposity"
(61 - 80 of 86)

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