Searched for: subject:"Adiposity"
(1 - 20 of 21)

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Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...
article 2017
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Kardinaal, A.F.M. (author), van Erk, M.J. (author), Dutman, A.E. (author), Stroeve, J.H.M. (author), van de Steeg, E. (author), Bijlsma, S. (author), Kooistra, T. (author), van Ommen, B. (author), Wopereis, S. (author)
Metabolism maintains homeostasis at chronic hypercaloric conditions, activating postprandial response mechanisms, which come at the cost of adaptation processes such as energy storage, eventually with negative health consequences. This study quantified the metabolic adaptation capacity by studying challenge response curves. After a high-fat...
article 2015
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Bakker, L.E.H. (author), Boon, M.R. (author), van der Linden, R.A.D. (author), Arias-Bouda, L.P. (author), van Klinken, J.B. (author), Smit, F. (author), Verberne, H.J. (author), Jukema, J.W. (author), Tamsma, J.T. (author), Havekes, L.M. (author), van Marken Lichtenbelt, W.D. (author), Jazet, I.M. (author), Rensen, P.C.N. (author)
Background: Individuals of south Asian origin have a very high risk of developing type 2 diabetes compared with white Caucasians. We aimed to assess volume and activity of brown adipose tissue (BAT), which is thought to have a role in energy metabolism by combusting fatty acids and glucose to produce heat and might contribute to the difference...
article 2014
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Bakker, G.C.M. (author), van Erk, M.J. (author), Pellis, L. (author), Wopereis, S. (author), Rubingh, C.M. (author), Cnubben, N.H.P. (author), Kooistra, T. (author), van Ommen, B. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background: Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Objective: It was hypothesized that specific dietary components are able to reduce low-grade inflammation as well as metabolic and oxidative stress. Design: Dietary products [resveratrol, green tea extract, α-tocopherol,...
article 2010
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Koppes, L.L.J. (author), Boon, N. (author), Nooyens, A.C.J. (author), van Mechelen, W. (author), Saris, W.H.M. (author), TNO Kwaliteit van Leven (author)
The distribution of the four macronutrients is associated with energy intake and body fatness according to short-term interventions. The present study involves macronutrient distribution in relation to energy intake and body fatness over a period of 23 years in individuals who have ad libitum access to food. Eight follow-up measurements have...
article 2009
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Lu, Z.F. (author), Zandieh-Doulabi, B. (author), Wuisman, P.I. (author), Bank, R.A. (author), Helder, M.N. (author), Gaubius Instituut TNO (author)
Tissue microenvironment plays a critical role in guiding local stem cell differentiation. Within the intervertebral disc, collagen type II and nucleus pulposus (NP) cells are two major components. This study aimed to investigate how collagen type II and NP cells affect adipose tissue-derived stem cells (ASCs) in a 3D environment. ASCs were...
article 2008
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Beulens, J.W.J. (author), van Beers, R.M. (author), Stolk, R.P. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Objective: To investigate the effect of moderate alcohol consumption on fat distribution, adipose tissue secreted proteins (adiponectin and resistin), and insulin sensitivity in healthy middle-aged men with abdominal obesity. Research Methods and Procedures: Thirty-four healthy men between 35 and 70 years old, with increased waist circumference ...
article 2006
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Euser, A.M. (author), Finken, M.J.J. (author), Keijzer-Veen, M.G. (author), Hille, E.T.M. (author), Wit, J.M. (author), Dekker, F.W. (author)
Background: Increasing evidence indicates that adult body composition is associated with prenatal and infancy weight gain, but the relative importance of different time periods has not been elucidated. Objective: The objective was to study the association between prenatal, early postnatal, and late infancy weight gain and body mass index (BMI),...
article 2005
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Sierksma, A. (author), Patel, H. (author), Ouchi, N. (author), Kihara, S. (author), Funahashi, T. (author), Heine, R.J. (author), Grobbee, D.E. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Preventie en Gezondheid (author)
OBJECTIVE - Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may...
article 2004
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Ferreira, I. (author), Snijder, M.B. (author), Twisk, J.W.R. (author), van Mechelen, W. (author), Kemper, H.C.G. (author), Seidell, J.C. (author), Stehouwer, C.D.A. (author), TNO Arbeid (author)
Central and peripheral fatness seem to confer opposite (i.e. adverse vs. protective) effects on cardiovascular risk, but how this occurs is not clear. In addition, the role of peripheral lean mass needs to be elucidated. We therefore investigated, in 336 (175 women) 36-yr-old and apparently healthy adults, the relationship between trunk fat,...
article 2004
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Berendschot, T.T.J.M. (author), Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Kardinaal, A.F.M. (author), van Poppel, G. (author), van Norren, D. (author), TNO Technische Menskunde (author)
Objective: To investigate whether nutritional factors and possible risk factors for cataract influence the lens optical density (LOD). Design: Three hundred seventy-six subjects, aged 18 to 75 years, were recruited. In a cross-sectional design, serum was analyzed for lutein, zeaxanthin, vitamin C, α-tocopherol, and cholesterol levels. Adipose...
article 2002
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Broekmans, W.M.R. (author), Berendschot, T.T.J.R. (author), Klöpping-Ketelaars, I.A.A. (author), de Vries, A.J. (author), Goldbohm, R.A. (author), Tijburg, L.B.M. (author), Kardinaal, A.F.M. (author), van Poppel, G. (author), TNO Voeding (author)
Background: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a...
article 2002
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Kockx, M. (author), Leenen, R. (author), Seidell, J. (author), Princen, H.M.G. (author), Kooistra, T. (author), Gaubius instituut TNO (author)
This study was aimed at evaluating the relationship between visceral fat accumulation and plasma plasminogen activator inhibitor-1 (PAI-1) levels in healthy, obese men and women undergoing weight loss therapy. The subjects, 25 men and 25 premenopausal women, aged between 26 and 49 years, with an initial body mass index between 28 and 38 kg/m2,...
article 1999
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Yudkin, J.S. (author), Stehouwer, C.D.A. (author), Emeis, J.J. (author), Coppack, S.W. (author), Gaubius instituut TNO (author)
C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown that subcutaneous adipose tissue secretes interleukin-6 in vivo. In this study we have sought associations of levels of C-reactive protein and interleukin-6 with...
article 1999
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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...
article 1998
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Simonsen, N. (author), van 't Veer, P. (author), Strain, J.J. (author), Martin-Moreno, J.M. (author), Huttunen, J.K. (author), Navajas, J.F.-C. (author), Martin, B.C. (author), Thamm, M. (author), Kardinaal, A.F.M. (author), Kok, F.J. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The fatty acid content of adipose tissue in postmenopausal breast cancer cases and controls from five European countries in the European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Cancer (EURAMIC) breast cancer study (1991-1992) was used to explore the hypothesis that fatty acids of the omega-3 family inhibit breast...
article 1998
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Giltay, E.J. (author), Elbers, J.M.H. (author), Gooren, L.J.G. (author), Emeis, J.J. (author), Kooistra, T. (author), Asscheman, H. (author), Stehouwer, C.D.A. (author), Gaubius Instituut TNO (author)
Increased plasminogen activator inhibitor type-1 (PAI-1) levels, leading to impaired fibrinolysis, are associated with increased visceral fat in middle-aged and obese subjects. It is unknown, however, whether this association is independent of other disturbances clustered in the insulin resistance syndrome. We analyzed this association in young,...
article 1998
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Boer, J.M.A. (author), Ehnholm, C. (author), Menzel, H.J. (author), Havekes, L.M. (author), Rosseneu, M. (author), O'Reilly, D.S.J. (author), Tiret, L. (author), Gaubius Instituut TNO (author)
To elucidate how the apolipoprotein (apo)E polymorphism and modifiable factors interact in explaining plasma lipid and apolipoprotein levels, we studied 1448 young adults (18 to 26 years old), participating in the European Atherosclerosis Research Study (EARS). Venous blood was collected after an overnight fast. Modifiable factors, eg, body mass...
article 1997
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van 't Veer, P. (author), Lobbezoo, E. (author), Martín-Moreno, J.M. (author), Guallar, E. (author), Gómez-Aracena, J. (author), Kardinaal, A.F.M. (author), Kohlmeier, L. (author), Martin, B.C. (author), Strain, J.J. (author), Thamm, M. (author), van Zoonen, P. (author), Baumann, B.A. (author), Huttunen, J.K. (author), Kok, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Objective: To examine any possible links between exposure to DDE (1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene), the persistent metabolite of the pesticide dicophane DDT), and breast cancer. Design: Multicentre study of exposure to DDE by measurement of adipose tissue aspirated from the buttocks. Laboratory measurements were conducted in a...
article 1997
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van 't Veer, P. (author), Strain, J.J. (author), Fernandez-Crehuet, J. (author), Martin, B.C. (author), Thamm, M. (author), Kardinaal, A.F.M. (author), Kohlmeier, L. (author), Huttunen, J.K. (author), Martin-Moreno, J.M. (author), Kok, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Antioxidants may protect against free radical mediated carcinogenesis. Epidemiological studies have not confirmed this hypothesis for breast cancer, possibly because of methodological limitations. Time-integrated exposure of α-tocopherol and β-carotene in adipose tissue, and selenium in toenails was investigated in a case-control study among...
article 1996
Searched for: subject:"Adiposity"
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