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Wang, R. (author), Damanik, F. (author), Kuhnt, T. (author), Jaminon, A. (author), Hafeez, S. (author), Liu, H. (author), Ippel, H. (author), Dijkstra, P.J. (author), Bouvy, N. (author), Schurgers, L. (author), ten Cate, A.T. (author), Dias, A. (author), Moroni, L. (author), Baker, M.B. (author)Digital light processing (DLP) is an accurate and fast additive manufacturing technique to produce a variety of products, from patient-customized biomedical implants to consumer goods. However, DLP's use in tissue engineering has been hampered due to a lack of biodegradable resin development. Herein, a library of biodegradable poly(esters)...article 2023
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Bex, G.J.P. (author), Ingenhut, B.L.J. (author), ten Cate, T. (author), Sezen, M. (author), Ozkoc, G. (author)The use of recycled polymers in 3D printing technologies has recently become a promising research topic because of the global concerns on plastic waste pollution and an increase in awareness of sustainability and circularity. In order to unlock the potentials of 3D printing beyond prototyping purposes, continuous fiber-embedded fused filament...article 2021
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van Leeuwen, H.C. (author), Roelofs, D. (author), Corver, J. (author), Hensbergen, P. (author)Pro-Pro-endopeptidases (PPEP, EC 3.4.24.89) are secreted, zinc metalloproteases that have the unusual capacity to cleave a peptide bond between two prolines, a bond that is generally less sensitive to proteolytic cleavage. Two well studied members of the family are PPEP-1 and PPEP-2, produced by Clostridioides difficile, a human pathogen, and...article 2021
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Eslami Amirabadi, H. (author), Tuerlings, M. (author), Hollestelle, A. (author), SahebAli, S. (author), Luttge, R. (author), van Donkelaar, C.C. (author), Martens, J.W.M. (author), den Toonder, J.M.J. (author)E-cadherin is a cell-cell adhesion protein that plays a prominent role in cancer invasion. Inactivation of E-cadherin in breast cancer can arise from gene promoter hypermethylation or genetic mutation. Depending on their E-cadherin status, breast cancer cells adopt different morphologies with distinct invasion modes. The tumor microenvironment ...article 2019
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Arutinov, G. (author), Giesbers, M. (author), van Waalwijk van Doorn, S. (author), Chiappini, F. (author), Kusters, R. (author), van den Brand, J. (author)This paper reports the use of Laser-induced Forward Transfer (LIFT) technology for printing of multilayer flexible circuitries and the fabrication of micro-bumps for flip-chip bonding of packaged LEDs and bare die microcomponents. Bonding of passive and functional surface mount devices (SMD) on low-temperature polyethylene terephthalate (PET)...conference paper 2018
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Remels, A.H.V. (author), Derks, W.J.A. (author), Cillero-Pastor, B. (author), Verhees, K.J.P. (author), Kelders, M.C. (author), Heggermont, W. (author), Carai, P. (author), Summer, G. (author), Ellis, S.R. (author), de Theije, C.C. (author), Heeren, R.M.A. (author), Heymans, S. (author), Papageorgiou, A.P. (author), van Bilsen, M. (author)Acute viral myocarditis (VM), characterised by leukocyte infiltration and dysfunction of the heart, is an important cause of sudden cardiac death in young adults. Unfortunately, to date, the pathological mechanisms underlying cardiac failure in VM remain incompletely understood. In the current study, we investigated if acute VM leads to cardiac...article 2018
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van Keulen, D. (author), Pouwer, M.G. (author), Pasterkamp, G. (author), van Gool, A.J. (author), Sollewijn Gelpke, M.D. (author), Princen, H.M.G. (author), Tempel, D. (author)Aims Endothelial activation is involved in many chronic inflammatory diseases, such as atherosclerosis, and is often initiated by cytokines. Oncostatin M (OSM) is a relatively unknown cytokine that has been suggested to play a role in both endothelial activation and atherosclerosis. We comprehensively investigated the effect of OSM on...article 2018
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Turkenburg, D.H. (author), van Bracht, H. (author), Funke, B. (author), Schmider, M. (author), Janke, D. (author), Fischer, H.R. (author): A facile two-step process is developed to obtain polyester urethanes that contain various concentrations of thermoreversible Diels–Alder adduct–based bonds for the development of adhesives. Besides linear systems thermoreversible networks have been included in the study. The reactions are verified using IR-spectroscopy and gel permeation...article 2017
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Fischer, H.R. (author), Mookhoek, S.D. (author)Six different bitumina of comparable PEN grade were investigated to gain a relation between the compositionarticle 2016
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Higuera, G.A. (author), Fernandes, H. (author), Spitters, T.W.G.M. (author), van de Peppel, J. (author), Aufferman, N. (author), Truckenmueller, R. (author), Stoop, R. (author), van Leeuwen, J.P. (author), de Boer, J. (author), Subramaniam, V. (author), Karperien, M. (author), van Blitterswijk, C. (author), van Boxtel, A. (author), Moroni, L. (author)Cells and tissues are intrinsically adapted to molecular gradients and use them to maintain or change their activity. The effect of such gradients is particularly important for cell populations that have an intrinsic capacity to differentiate into multiple cell lineages, such as bone marrow derived mesenchymal stromal cells (MSCs). Our results...article 2015
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Sridhar, A. (author), Perinchery, S.M. (author), Smits, E.C.P. (author), Mandamparambil, R. (author), van den Brand, J. (author)The reliability of a commercially available isotropic conductive adhesive (ICA) deposited via laser induced forward transfer (LIFT) printing is reported. ICAs are particularly important for surfacemount device (SMD) integration onto low-cost, large-area system-in-foil (SiF) applications such as radio frequency identification (RFID) transponder...article 2015
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Mulder, P. (author), Stavro, P.M. (author), Manuel Suárez, M. (author), Arola-Arnal, A. (author), van Duyvenvoorde, W. (author), Kooistra, T. (author), Wielinga, P.Y. (author), Kleemann, R. (author)Background and Aims As dietary saturated fatty acids are associated with metabolic and cardiovascular disease, a potentially interesting strategy to reduce disease risk is modification of the quality of fat consumed. Vegetable oils represent an attractive target for intervention, as they largely determine the intake of dietary fats. Furthermore,...article 2015
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Fischer, H.R. (author), Gelinck, E. (author), Semprimoschnig, C. (author), van Munster, M. (author), van der Heijden, J. (author)ct A direct bonding process relying on van der Waals forces offers an ideal combination of easiness to assemble and material compatibility. Such a bonding procedure, also denoted as optical bonding, is already known and used frequently in different applications. However, there are strict requirements to achieve optical bonding: (1) a high level...article 2015
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Wagner, A. (author), Cohen, N. (author), Kelder, T. (author), Amit, U. (author), Liebman, E. (author), Steinberg, D.M. (author), Radonjic, M. (author), Ruppin, E. (author)High-throughput omics have proven invaluable in studying human disease, and yet day-to-day clinical practice still relies on physiological, non-omic markers. The metabolic syndrome, for example, is diagnosed and monitored by blood and urine indices such as blood cholesterol levels. Nevertheless, the association between the molecular and the...article 2015
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Michels, J.J. (author), Peter, M. (author), Salem, A. (author), van Remoortere, B. (author), van den Brand, J. (author)This paper presents a thorough experimental and theoretical analysis of a model system for the mechanism of cathode degradation in OLED and OPV devices due to lateral side ingress of water vapour into laminated thin film barrier structures. The experimental procedure allows for full quantitative control over layer dimensions of the laminate, as...article 2014
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Perinchery, S.M. (author), Smits, E.C.P. (author), Sridhar, A. (author), Albert, P. (author), van den Brand, J. (author), Mandamparambil, R. (author), Yakimets, I. (author), Schoo, H.F.M. (author)Laser induced forward transfer is an emerging material deposition technology. We investigated the feasibility of this technique for printing thermally sensitive, electrically conductive adhesives with and without using an intermediate dynamic release layer. A 248nm KrF-excimer laser was used to print the epoxy-based conductive adhesives...article 2014
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Gierman, L.M. (author), Kühnast, S. (author), Koudijs, A. (author), Pieterman, E.J. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Princen, H.M.G. (author), Zuurmond. A.M., (author)Objective Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis, the effect of cholesterol and different cholesterol-lowering treatments on OA was investigated in a mouse model resembling human lipoprotein metabolism. Methods Female...article 2014
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Peter, M. (author), van den Ende, D. (author), van Remoortere, B. (author), van Put, S. (author), Podprocky, T. (author), Henckens, A. (author), van den Brand, J. (author)Systems-in-foil technologies address the current need to manufacture low-cost, low-complexity and high-reliabiltiy large area organic electronics in the field of OLEDs, OPVs and sensors. For substrates with multiple layers of conductive tracks, there is a need to realize contact positions on either side of the foil. Unfortunately, typical...conference paper 2013
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Fischer, H.R. (author), Dillingh, E.C. (author), Hermse, C.G.M. (author)The interfacial interaction between bituminous binders and several mineral surfaces of different chemical nature as present in asphalt mixtures has been investigated using atomic force microscopy. Several dry mineral surfaces display comparable wetting with respect to the different phases present in the micro-structure of bitumen, regardless of...article 2013
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...article 2013