Ontwikkelingen in de diagnostiek en behandeling van leukemie bij kinderen met downsyndroom = Developments in diagnosis and treatment of leukemia in children with Down syndrome

Children with Down syndrome (DS) have an increased risk for developing both acute myeloid as well as acute lymphoblastic leukemia. These leukemias differ in clinical characteristics and biology compared to leukemias in non-DS children. Moreover, children with DS have an increased risk of side-effects from cytostatic therapy, which complicates...