- document
-
Savolainen, K. (author), Pylkkänen, L. (author), Norppa, H. (author), Falck, G. (author), Lindberg, H. (author), Tuomi, T. (author), Vippola, M. (author), Alenius, H. (author), Hämeri, K. (author), Koivisto, J. (author), Brouwer, D. (author), Mark, D. (author), Bard, D. (author), Berges, M. (author), Jankowska, E. (author), Posniak, M. (author), Farmer, P. (author), Singh, R. (author), Krombach, F. (author), Bihari, P. (author), Kasper, G. (author), Seipenbusch, M. (author), TNO Kwaliteit van Leven (author)The significance of engineered nanomaterials (ENM) and nanotechnologies grows rapidly. Nanotechnology applications may have a positive marked impact on many aspects of on human every day life, for example by providing means for the production of clean energy and pure drinking water. Hundreds of consumer nano-based products are already on the...article 2010
- document
-
Borst, H.C. (author), Salomons, E.M. (author), Lohman, W.J.A. (author), Zhou, H. (author), Miedema, H.M.E. (author), TNO Bouw en Ondergrond (author)Spatial planning in urban areas is complex. Besides noise from different source types, many other aspects play a role. In order to support local authorities and others involved in spatial planning, TNO has developed an interactive instrument: 'Urban Strategy', which integrates a detailed interactive noise map with other aspects such as traffic...conference paper 2009
- document
-
Elzendoorn, B. (author), de Baar, M. (author), Chavan, R. (author), Goodman, T. (author), Heemskerk, C. (author), Heidinger, R. (author), Kleefeldt, K. (author), Koning, J. (author), Sanders, S. (author), Späh, P. (author), Strauss, D. (author), Verhoeven, T. (author), de Vreede, F. (author), TNO Industrie en Techniek (author)All ITER sub-systems of remote handling (RH) classes 1 and 2 have to be remotely maintainable. The maintenance strategy for these components has to ensure system availability after failure or scheduled maintenance. This paper shows how virtual reality (VR) simulation [1] can be used as a tool to analyze the maintenance process, to predict the...article 2009
- document
-
TNO Kwaliteit van Leven (author), Marquart, H. (author), Heussen, H. (author), Le Feber, M. (author), Noy, D. (author), Tielemans, E. (author), Schinkel, J. (author), West, J. (author), van der Schaaf, D. (author)In the scope of a Dutch programme to reinforce the working conditions policy on hazardous substances, an internet-based tool was developed to help small- and medium-sized companies to handle hazardous substances with more care. The heart of this tool, called the Stoffenmanager, is a risk banding scheme. It combines a hazard banding scheme...article 2008
- document
-
TNO Defensie en Veiligheid (author), Neerincx, M.A. (author), Lindenberg, J. (author), Smets, N.J.J.M. (author), Bos, A. (author), Breebaart, L. (author), Grant, T. (author), Olmedo-Soler, A. (author), Brauer, U. (author), Wolff, M. (author)Manned long-duration missions to the Moon and Mars set high operational, human factors and technical demands for a distributed support system, which enhances human-machine teams' capabilities to cope autonomously with unexpected, complex and potentially hazardous situations. Based on a situated Cognitive Engineering (sCE) method, we specified a...conference paper 2008
- document
-
Smeets, P.A.M. (author), Vidarsdottir, S. (author), de Graaf, C. (author), Stafleu, A. (author), van Osch, M.J.P. (author), Viergever, M.A. (author), Pijl, H. (author), van der Grond, J. (author), TNO Kwaliteit van Leven (author)We previously showed that hypothalamic neuronal activity, as measured by the blood oxygen level-dependent (BOLD) functional MRI signal, declines in response to oral glucose intake. To further explore the mechanism driving changes in hypothalamic neuronal activity in response to an oral glucose load, we here compare hypothalamic BOLD signal...article 2007
- document
-
Cremers, A.H.M. (author), Kuijper, I. (author), Groenewegen, P.L.M. (author), Post, W.M. (author), TNO Defensie en Veiligheid (author)The objective of our study was to design and evaluate a user interface concept for a so-called Project Browser, following a user-centered design method. Previous work has suggested that users prefer to access project-related information instrumental to the task they have to carry out. First, a domain analysis was carried out, followed by an...conference paper 2007
- document
-
Tenjarla, S. (author), Romasanta, V. (author), Zeijdner, E. (author), Villa, R. (author), Moro, L. (author), TNO Kwaliteit van Leven (author)5-Aminosalicylate (5-ASA; mesalamine) is the current first-line treatment for mild to moderate ulcerative colitis, a chronic inflammatory condition that most commonly affects the distal part of the colon. MMX™ mesalamine (Lialda™ [US]; Mezavant™ XL [UK and Ireland]; Mezavant™ [elsewhere]; Shire Pharmaceuticals Inc., Wayne, Pa, under license from...article 2007
- document
-
Cremers, A.H.M. (author), Kuiper, I. (author), Groenewegen, P. (author), Post, W.M. (author), TNO Defensie en Veiligheid (author)Abstract. The objective of our study was to design and evaluate a user interface concept for a so-called Project Browser, following a user-centered design method. Previous work has suggested that users prefer to access project-related information instrumental to the task they have to carry out. First, a domain analysis was carried out, followed...conference paper 2007
- document
-
Gijsen, B.M.M. (author), van der Mei, R.D. (author), Engelberts, P. (author), van den Berg, J.L. (author), van Wingerden, K.M.C. (author), TNO Informatie- en Communicatietechnologie (author)This paper is motivated by the response-time analysis of distributed information systems, where transactions are handled by a sequence of front-end server and back-end server actions. We study sojourn times in an open queueing network with a single Processor Sharing (PS) node and an arbitrary number of M multi-server First-Come-First-Served ...article 2006
- document
-
Schaafsma, G. (author), TNO Kwaliteit van Leven (author)The increasing prevalence in many countries of people with overweight and obesity is undoubtedly one of the biggest threats to public health. Dietary proteins, because of their positive effects on satiation/ satiety, may help to reduce energy intake and promote a healthy body composition with less body fat. Several mechanisms have been put...article 2006
- document
-
Borst, H.C. (author), Miedema, H.M.E. (author), van der Laan, W.P.N. (author), Lohman, W.J.A. (author), TNO Bouw en Ondergrond (author)Noise annoyance due to transportation is widespread in industrialized countries and in urban areas in the developing countries. The European Noise Directive (END) requires an assessment of the noise situation as well as the formulation of action plans for the reduction of the number of people harmfully affected by environmental noise. In this...conference paper 2006
- document
-
Bluyssen, P.M. (author), Adan, O.C.G. (author), TNO Bouw en Ondergrond (author)The need for indoor environment to be addressed at the EU level is recognised, shown by the Environment and Health Action plan (CEC, 2004), the WHO ministerial declaration (WHO, 2004), but also by the Strategic Research Agenda of the European Construction Technology Platform. Several national and international initiatives at different levels are...conference paper 2006
- document
-
Heijboer, A.C. (author), van den Hoek, A.M. (author), Parlevliet, E.T. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), Corssmit, E.P.M. (author), TNO Kwaliteit van Leven (author)Aims/hypothesis: This study was conducted to evaluate the effects of ghrelin on insulin's capacity to suppress endogenous glucose production and promote glucose disposal in mice. To establish whether the growth hormone secretagogue (GHS) receptor can mediate the putative effect of ghrelin on the action of insulin, we also determined the...article 2006
- document
-
Blankvoort, B.M.G. (author), Rodenburg, R.J.T. (author), Murk, A.J. (author), Koeman, J.H. (author), Schilt, R. (author), Aarts, J.M.M.J.G. (author), TNO Kwaliteit van Leven (author)This paper describes the screening of 22 extracts from 18 different aquatic environmental samples for androgenic activity, including indirect and interactive effects on androgen receptor (AR)-mediated signal transduction, using the AR-LUX bioassay. Four samples, originating from an industrial wastewater treatment plant (WTP) or the river Meuse,...article 2005
- document
-
van Hooft, E.A.J. (author), Born, M. (author), Taris, T.W. (author), van der Flier, H. (author), Blonk, R.W.B. (author), TNO Kwaliteit van Leven (author)In the context of Ajzen's (1991) theory of planned behavior, the antecedents of intentions are better understood than the antecedents of behavior. The current study aimed to improve the understanding of the transition from intentions to behavior. Based on the work of Gollwitzer (1993), Kuhl and Beckmann (1994), and Lay (1986) we proposed a model...article 2005
- document
-
TNO Kwaliteit van Leven (author), Heijboer, A.C. (author), Donga, E. (author), Voshol, P.J. (author), Dang, Z.C. (author), Havekes, L.M. (author), Romijn, J.A. (author), Corssmit, E.P.M. (author)Fasting readily induces hepatic steatosis. Hepatic steatosis is associated with hepatic insulin resistance. The purpose of the present study was to document the effects of 16 h of fasting in wild-type mice on insulin sensitivity in liver and skeletal muscle in relation to 1) tissue accumulation of triglycerides (TGs) and 2) changes in mRNA...article 2005
- document
-
Peters, J.W.B. (author), Koot, H.M. (author), Grunau, R.E. (author), de Boer, J. (author), van Druenen, M.J. (author), Tibboel, D. (author), Duivenvoorden, H.J. (author), TNO Preventie en Gezondheid (author)Objective: The objectives of this study were to: (1) evaluate the validity of the Neonatal Facial Coding System (NFCS) for assessment of postoperative pain and (2) explore whether the number of NFCS facial actions could be reduced for assessing postoperative pain. Design: Prospective, observational study. Patients: Thirty-seven children (0-18...article 2003
- document
-
TNO Voeding (author), Eggen, R.I.L. (author), Bengtsson, B.E. (author), Bowmer, C.T. (author), Gerritsen, A.A.M. (author), Gibert, M. (author), Hylland, K. (author), Johnson, A.C. (author), Leonards, P. (author), Nakari, T. (author), Norrgren, L. (author), Sumpter, J.P. (author), Suter, M.J.F. (author), Svenson, A. (author), Pickering, A.D. (author)Between January 1999 and December 2001, the European Community project COMPREHEND was performed. The overall aim of COMPREHEND was to assess endocrine disruption in the aquatic environment in Europe, consequent to effluent discharge, with emphasis on estrogenic activity. COMPREHEND demonstrated the widespread occurrence of estrogenic effluents...article 2003
- document
-
Tajima, O. (author), Schoen, E.D. (author), Feron, V.J. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This paper presents a test strategy to detect interactive effects between several mycotoxins using a DNA synthesis inhibition assay in L929 cells. The joint action of the Fusarium mycotoxins T-2 toxin (T2), deoxynivalenol (DON), nivalenol (NIV), zearalenone (ZEA) and fumonisin (FB1) was studied in a tiered approach. In the first stage, the...article 2002