Searched for: subject%3A%22%25CE%25B1B%255C-Crystallin%22
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van Noort, J.M. (author), Bsibsi, M. (author), Gerritsen, W.H. (author), van der Valk, P. (author), Bajramovic, J.J. (author), Steinman, L. (author), Amor, S. (author), TNO Kwaliteit van Leven (author)
We present the first comparative analysis of serum immunoglobulinG reactivity profiles against the full spectrum of human myelin-associated proteins in multiple sclerosis patients and healthy control subjects. In both groups, serum antibodies display a consistent and prominent reaction to αB-crystallin (CRYAB) versus other myelin proteins. As an...
article 2010
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Verbeek, R. (author), van der Mark, K. (author), Wawrousek, E.F. (author), Plomp, A.C. (author), van Noort, J.M. (author), TNO Kwaliteit van Leven (author)
Tolerance induction to prevent activation of a naïve T-cell repertoire has been well documented in rodents and can be readily achieved by intravenous, oral or intranasal administration of antigen in the absence of adjuvants. In autoimmune diseases such as multiple sclerosis (MS) the presence of an established memory/effector T-cell repertoire...
article 2007
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Çelet, B. (author), Akman-Demir, G. (author), Serdaroǧlu, P. (author), Yentür, S.P. (author), Taşci, B. (author), van Noort, J.M. (author), Eraksoy, M. (author), Saruhan-Direskeneli, G. (author), TNO Preventie en Gezondheid (author)
αB-Crystallin, a small heat shock protein, is an immuno-dominant antigen with increased tissue expression in demyelination. To investigate the humoral response against αB-crystallin, the sera and CSF samples of patients with multiple sclerosis (MS), Guillain-Barré syndrome (GBS), neuro-Behçet's disease (NBD) and other non-inflammatory...
article 2000
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Thoua, N.-M. (author), van Noort, J.M. (author), Baker, D. (author), Bose, A. (author), van Sechel, A.C. (author), van Stipdonk, M.J.B. (author), Travers, P.J. (author), Amor, S. (author), TNO Preventie en Gezondheid (author)
The stress protein αB-crystallin is an immunodominant antigen in multiple sclerosis (MS)-affected myelin for human T cells and is expressed at elevated levels in MS lesions. Using bovine αB-crystallin and synthetic peptides based on mouse αB-crystallin the ability of this stress protein to induce experimental allergic encephalomyelitis (EAE) was...
article 2000
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van Stipdonk, M.J.B. (author), Willems, A.A. (author), Amor, S. (author), Persoon-Deen, C. (author), Travers, P.J. (author), Boog, C.J.P. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
Factors such as developmental stage or physiological and infectious stress may change patterns of post-translational protein modification. In order to determine whether such regulated types of modification may influence T cell responsiveness to self proteins we examined the T cell response of SJL (H-2(S)) mice to αB-crystallin, a small heat...
article 1998
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Bajramović, J.J. (author), Lassmann, H. (author), van Noort, J.M. (author), TNO Preventie en Gezondheid (author)
The small heat shock protein αB-crystallin was recently identified as a dominant human T-cell antigen in myelin derived from multiple sclerosis (MS) patients. Using immunohistochemical techniques, oligodendrocytes as well as astrocytes in MS lesions were shown to express α B-crystallin. In the present study we examined the expression of α B...
article 1997
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