Human-Centred Design and its inherent ethical qualities

Human-centred design (HCD) is an approach which enables designers, developers and engineers to focus their projects on prospective users of the products or services they are working on. It enables them to focus on users’ experiences and to involve them throughout the process of design and development, in an iterative and multidisciplinary...

Cross-sectoral integrated assessment of alternatives for climate mitigation in Madagascar

Using the integrated assessment model TIAM-ECN, we analyze how Madagascar’s nationally determined contribution (NDC) to the Paris Agreement can be implemented in both the energy and non-energy sectors. We explore how the country’s national climate goal for 2030 can be reached under two different cost levels for climate change mitigation through...

Drones - Dull, dirty or dangerous?: The social construction of privacy and security technologies

The Western world has experienced brutal attacks on a number of capitals over the past 10 years (Madrid, London, Paris, Brussels). While the background of the attacks may differ in the sense that different groups of terrorists were responsible for these attacks (Al Qaida and IS), each attack gave rise to intensified discourses on the need to...

An integration of human factors into quantitative risk analysis: A proof of principle

Quantitative Risk Analysis (QRA) is a standard and mandatory tool in some high-risk industries (such as the on-and offshore exploration and production and chemical industry). Presently, the human factor component is often estimated using expert opinions. In practice, experts may use heuristics such as assuming a failure probability of one in ten...

Privacy and security: Citizens’ desires for an equal footing

Input-output analysis and resource nexus assessment

Docking and molecular dynamics studies of peripheral site ligand–oximes as reactivators of sarin-inhibited human acetylcholinesterase

In the present work, we performed docking and molecular dynamics simulations studies on two groups of long-tailored oximes designed as peripheral site binders of acetylcholinesterase (AChE) and potential penetrators on the blood brain barrier. Our studies permitted to determine how the tails anchor in the peripheral site of sarin-inhibited human...

On-line monitoring of electrolytes in hemodialysis: On the road towards individualizing treatment

Introduction: End-stage renal disease (ESRD) patients depend on dialysis for removal of toxic waste products, fluid overload relief and maintenance of electrolyte balance. Dialysis prolongs millions of lives. To some extent, ESRD has become a manageable disease with a steadily growing dialysis population of increasing average age and associated...

The fatigue strength of base material and butt welds made of S690 and S1100

Modern steel manufacturing techniques make it possible to produce steel with nominal strengths up to 1100 MPa (very high strength steels, VHSS). For the design of cyclic loaded slender VHSS structures, the fatigue strength of both base material and welded components should be known. In a VHSS fatigue loaded structure absolute and relative stress...

MF-Swift simulation study using benchmark data

The accuracy of tyre models depends to a large extent on the measurement data used to assess model parameters. The MF-Swift tyre model parameters can be identified or estimated from various combinations of experimental data. The amount and required accuracy of the measurement data can be selected according to the tyre model application. This...