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Walczak, A.P. (author), Kramer, E. (author), Hendriksen, P.J.M. (author), Tromp, P. (author), Helsper, J.P.F.G. (author), van der Zande, M. (author), Rietjens, I.M.C.M. (author), Bouwmeester, H. (author)
Intestinal translocation is a key factor for determining bioavailability of nanoparticles (NPs) after oral uptake. Therefore, we evaluated three in vitro intestinal cell models of increasing complexity which might affect the translocation of NPs: a mono-culture (Caco-2 cells), a co-culture with mucus secreting HT29-MTX cells and a tri-culture...
article 2015
Woutersen, R.A. (author), Slootweg, P.J. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
Inhalation toxicity testing is becoming increasingly important, among other things because of the increasing number of drugs that are administered through the intranasal route to avoid enzymatic and acid breakdown and first pass metabolism in the gastrointestinal mucosa and the liver. The nature and site of damage to the nasal mucosa are...
conference paper 2010