Searched for: mods_originInfo_dateIssued_s:"2021"
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Schlunk, F. (author), Fisher, P. (author), Princen, H.M.G. (author), Rex, A. (author), Prinz, V. (author), Foddis, M. (author), Lütjohann, D. (author), Laufs, U. (author), Endres, M. (author)
Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PSCK9) neutralizing antibodies effectively lower plasma cholesterol levels and decrease cardiovascular events but also raised some concern that cognitive function could worsen as a side effect. Here, we performed experiments in mice to characterize the effect of anti-PCSK9 antibodies...
article 2021
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Hamdiui, N. (author), Marchena, E. (author), Stein, M.L. (author), van Steenbergen, J.E. (author), Crutzen, R. (author), van Keulen, H.M. (author), Reis, R. (author), van den Muijsenbergh, M.E.T.C. (author), Timen, A. (author)
Objectives: Whether the lower Dutch cervical cancer (CC) screening participation of Turkish- and Moroccan-Dutch women is based on informed decision-making is unknown. Our aim was to explore how and why Turkish- and Moroccan-Dutch women decide to participate or not in the current Dutch CC screening programme as well as to learn their perceptions...
article 2021
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Kuijpers, E. (author)
Occupational diseases are a huge burden on society. Despite significant control efforts, yearly thousands of former workers die from occupational exposures and even more are injured or suffer from health effects. To further prevent occupational diseases we need a way to monitor our working environment more continuously and in (near) real-time....
public lecture 2021
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Olga, L. (author), van Diepen, J.A. (author), Bobeldijk-Pastorova, I. (author), Gross, G. (author), Prentice, S.M. (author), Snowden, S.G. (author), Furse, S. (author), Kooistra, T. (author), Hughes, I.A. (author), Schoemaker, M.H. (author), van Tol, E.A.F. (author), van Duyvenvoorde, W. (author), Wielinga, P.Y. (author), Ong, K.K. (author), Dunger, D.B. (author), Kleemann, R. (author), Koulman, A. (author)
Background: Altered lipid metabolism in early life has been associated with subsequent weight gain and predicting this could aid in obesity prevention and risk management. Here, a lipidomic approach was used to identify circulating markers for future obesity risk in translational murine models and validate in a human infant cohort. Methods:...
article 2021
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Schaafsma, F.G. (author), Hulsegge, G. (author), de Jong, M.A. (author), Overvliet, J. (author), van Rossum, E.F.C. (author), Nieuwenhuijsen, K. (author)
Objectives: Workplace-based selective prevention of mental health problems currently relies on subjective evaluation of stress complaints. Hair cortisol captures chronic stress responses and could be a promising biomarker for the early identification of mental health problems. The objective was to provide an overview of the state-of-the-art...
article 2021
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Kamphuis, W. (author), Delahaij, R. (author), Duel, J. (author), Geuze, E. (author), Vermetten, E. (author)
Veterans may report PTSD symptoms, years after their deployment. The aim of this study was to examine whether the presence of resilience resources before deployment, and the potential loss of these resources over time, are associated with the risk of PTSD symptoms five years post-deployment. The study focused on Dutch service members, deployed...
article 2021
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Houtman, I.L.D. (author), Kraan, K.O. (author), Venema, A. (author), de Vroome, E. (author)
Burn-outklachten onder werknemers laten, na de kredietcrisis, in Nederland een gestage en forse stijging zien – van 14,4 procent in 2014 tot 17,3 procent in 2018. Hoe is die stijging te verklaren? Data over arbeidsomstandigheden kunnen de toename in burnoutklachten voor bijna 39 procent verklaren. De belangrijkste gemeten oorzaken zijn...
article 2021
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Goldberg, T. (author), Hennekam, R. (author), Wasch, L.J. (author), Reichart, G.J. (author), Rach, O. (author), Stammeier, J.A. (author), Griffioen, J. (author)
Multi-element analysis of discrete samples via X-Ray fluorescence or inductively coupled plasma spectrometry is commonly used to characterise the composition of solid geo-materials for environmental geochemical characterisation. Conventional geochemical analysis of individual samples is time consuming and costly, which often results in low...
article 2021
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Nedeljkovic, M. (author), Visser, J.H.M. (author), Nijland, T.G. (author), Valcke, S.L.A. (author), Schlangen, E. (author)
In circular concrete design, beside cement replacement with more environmentally friendly cement types, there is also an urgent need for sand replacement with fine recycled concrete aggregates (fRCA). The variations in physical and chemical properties of fRCA and lack of standards for their quality evaluation are the main reasons for not yet...
article 2021
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Vonk Noordegraaf, D.M. (author), Bouma, G.M. (author), Larco N., (author), Munzel, K.L. (author), Heezen, M.J.M. (author)
The Dutch Ministry of Infrastructure and Water Management (IenW) asked TNO to carry out an independent, comparative case study on the governance of Mobility as a Service (MaaS). This has a focus on a comparable scale (i.e. comparable to the Netherlands in terms of geography/ number of inhabitants) through the description and comparison of...
report 2021
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Powell, T.E. (author), Hameleers, M. (author), van der Meer, T.G.L.A. (author)
The psychological bases of the selection and attitudinal response to news media have received ample attention in political communication research. However, the interplay between three crucial factors in today’s online, high-choice news media settings remains understudied: (1) textual versus multimodal (text-plus-visual) communication; (2)...
article 2021
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Goemans, B.F. (author), Noort, S. (author), Blink, M. (author), Wang, Y.D. (author), Peters, S.T.C.J. (author), van Wouwe, J.P. (author), Kaspers, G. (author), de Haas, V. (author), Kollen, W.J. (author), van der Velden, V.H.J. (author), Gruber, T.A. (author), Zwaan, C.M. (author)
The aim of this study was to define a population-based frequency of TAM in DS newborns. The Dutch Pediatric Surveillance Unit (DPSU) registers newborns with DS and TAM screening was added to this registration from Jan 1, 2008, until Jan 1, 2013 (Erasmus MC MEC-2007-168, Netherlands Trial Register NL1587). Based on the live birth prevalence of DS...
article 2021
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de Amorim Soares, G. (author), Carolus, J. (author), Daenen, M. (author), Masolin, A. (author), Birrenbach, T. (author), Gerber, A. (author), Wrigley, A. (author), Henzel, J. (author), Roosen, D. (author), Meuris, M. (author), Theelen, M.J. (author)
A round robin test was carried out in four PV laboratories to compare accelerated lifetime testing. Twenty commercial non-packaged CIGS solar cells of similar performance were spread and exposed to damp heat con-ditions (85 ◦C and 85% RH) for approximately 500 h. Their JV performance was monitored during the damp heat exposure. After the test,...
article 2021
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Guffanti, S. (author), Visconti, C.G. (author), an Kampen, J. (author), Boon, J. (author), Groppi, G. (author)
Sorption Enhanced DiMethyl Ether Synthesis (SEDMES) is a promising option to overcome thermodynamic limitations of conventional DME production processes. In this work a 2D+1D heterogeneous dynamic model of the reaction/adsorption step in a tube of an externally cooled multitubular fixed bed SEDMES reactor is developed in order to investigate the...
article 2021
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Abokersh, M.H. (author), Spiekman, M.E. (author), Vijlbrief, O. (author), van Goch, T.A.J. (author), Vallies, M. (author), Boer, D. (author)
The nearly zero-energy buildings (nZEB) presents a promising contribution to fulfill the EU sustainable future targets. However, the construction industry that leads the development of nZEB is facing challenges to guarantee its performance. In this context, this paper proposes a methodology framework based on Multizone Resistance–Capacitance...
article 2021
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Xiao, C. (author), Leeuwenburgh, O. (author), Lin, H.X. (author), Heemink, A. (author)
A reduced order modeling algorithm for the estimation of space varying parameter patterns in numerical models is proposed. In this approach domain decomposition is applied to construct separate approximations to the numerical model in every subdomain. We introduce a new local parameterization that decouples the computational cost of the...
article 2021
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Caron, J.F. (author), Bäumer, S.M.B. (author)
The aberrations of reflective optical systems with one plane of symmetry are investigated in the most general case, with freeform surfaces and possibly different locations of the tangential and sagittal object and image. In this first paper in a series of two, we establish generalized ray-tracing equations including transverse aberrations up to...
article 2021
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Caron, J.F. (author), Bäumer, S.M.B. (author)
The aberrations of reflective optical systems with planar symmetry are investigated in the most general case, with freeform surfaces and possibly different locations of the tangential and sagittal object and image. In this second and last paper, closed-form expressions are derived for the aberrations created by an individual mirror. We study two...
article 2021
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Fokker, P.A. (author), Borello, E.S. (author), Viberti, D. (author), Verga, F. (author), van Wees, J.D. (author)
Seasonal storage of heat in shallow aquifers for increasing the efficiency of geothermal energy systems requires a proper monitoring strategy. We expanded our earlier work on harmonic pulse testing (HPT) to incorporate the effect of a temperature front moving into the reservoir due to injection of hot (or cold) water. Our analytical solutions...
article 2021
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Weemstra, C. (author), de Laat, J.I. (author), Verdel, A. (author), Smets, P. (author)
Instrumental timing and phase errors are a notorious problem in seismic data acquisition and processing. These can be frequency independent, for example due to clock drift, but may also be frequency dependent, for example due to imperfectly known instrument responses. A technique is presented that allows both types of errors to be recovered in a...
article 2021
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