Searched for: mods_originInfo_dateIssued_s:"2008"
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Scholten, N.P.M. (author), de Groot, E.H. (author), Zonneveldt, L. (author), TNO Bouw en Ondergrond (author)
article 2008
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), van der Linden, J.C. (author), Zuurmond, A.M. (author), Weinans, H. (author), Verhaar, J.A.N. (author), van Osch, G.J.V.M. (author), de Groot, J. (author), TNO Kwaliteit van Leven (author)
Background: Damage to articular cartilage is one of the features of osteoarthritis (OA). Cartilage damage is characterised by a net loss of collagen and proteoglycans. The collagen network is considered highly important for cartilage function but little is known about processes that control composition and function of the cartilage collagen...
article 2008
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Coulier, L. (author), van Kampen, J.J.A. (author), de Groot, R. (author), Gerritsen, H.W. (author), Bas, R.C. (author), van Dongen, W.D. (author), Brüll, L.P. (author), Luider, T.M. (author), TNO Kwaliteit van Leven (author), KvL (author)
Nucleoside reverse transcriptase inhibitors (NRTIs) are activated intracellularly to their triphosphate (TP) form, which compete with endogenous deoxynucleotide-triphosphates (dNTP) as substrate for HIV reverse transcriptase. The activity of NRTIs is thus described by the NRTI-TP to-dNTP ratio in relevant cell types. Therefore, we developed an...
article 2008
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Hunter, D.J. (author), LaValley, M. (author), Li, J. (author), Bauer, D.C. (author), Nevitt, M. (author), de Groot, J. (author), Poole, R. (author), Eyre, D. (author), Guermazi, A. (author), Gale, D. (author), Totterman, S. (author), Felson, D.T. (author), TNO Kwaliteit van Leven (author), KvL (author)
Introduction: Our objective was to determine whether markers of bone resorption and formation could serve as markers for the presence of bone marrow lesions (BMLs). Methods: We conducted an analysis of data from the Boston Osteoarthritis of the Knee Study (BOKS). Knee magnetic resonance images were scored for BMLs using a semiquantitative...
article 2008
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Henneman, S. (author), Bildt, M.M. (author), de Groot, J. (author), Kuijpers-Jagtman, A.M. (author), Von den Hoff, J.W. (author), TNO Kwaliteit van Leven (author)
article 2008
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Correia, L.A. (author), Jansen, D. (author), de Groot, A. (author), Overbeek, J.P. (author), Dijkstra, J.W. (author), van Delft, Y.C. (author), Meyer, D.F. (author), Energieonderzoek Centrum Nederland (author)
Palladium membrane reactors have been identified as a promising option for hydrogen production in future power production systems and industrial chemical production processes. This paper gives an overview of the results and current status of the palladium membrane reactor development at ECN for large-scale hydrogen production.
conference paper 2008
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Frost-Christensen, L.N. (author), Mastbergen, S.C. (author), Vianen, M.E. (author), Hartog, A. (author), de Groot, J. (author), Voorhout, G. (author), van Wees, A.M.C. (author), Lafeber, F.P.J.G. (author), Hazewinkel, H.A.W. (author), TNO Kwaliteit van Leven (author)
Objective: The most used model for joint instability is the canine anterior cruciate ligament transection (ACLT)-model. The ACLT-model can be extended with a medial meniscectomy (MX) (i.e., ACLT-MX-model) to avoid unintentional, and with that variable, meniscal damage. The present study compares the ACLT-MX-model with the more recently...
article 2008
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Sivan, S.-S. (author), Wachtel, E. (author), Tsitron, E. (author), Sakkee, N. (author), van der Ham, F. (author), de Groot, J. (author), Roberts, S. (author), Maroudas, A. (author), TNO Kwaliteit van Leven (author)
Knowledge of rates of protein turnover is important for a quantitative understanding of tissue synthesis and catabolism. In this work, we have used the racemization of aspartic acid as a marker for the turnover of collagen obtained from healthy and pathological human intervertebral disc matrices. We measured the ratio of the D- and L-isomers in...
article 2008
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Ashwell, M. (author), Lambert, J.P. (author), Alles, M.S. (author), Branca, F. (author), Bucchini, L. (author), Brzozowska, A. (author), de Groot, L.C.P.G.M. (author), Dhonukshe-Rutten, R.A.M. (author), Dwyer, J.T. (author), Fairweather-Tait, S. (author), Koletzko, B. (author), Pavlovic, M. (author), Raats, M.M. (author), Serra-Majem, L. (author), Smith, R. (author), van Ommen, B. (author), Veer, P.V. (author), Von Rosen, J. (author), Pijls, L.T.J. (author), TNO Kwaliteit van Leven (author)
Background: There is considerable variation in the recommended micronutrient intakes used by countries within Europe, partly due to different methodologies and concepts used to determine requirements and different approaches used to express the recommendations. As populations become more mobile and multi-national, and more traditional foods...
article 2008
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Tchetverikov, I. (author), Kraan, M.C. (author), van El, B. (author), Hanemaaijer, R. (author), de Groot, J. (author), Huizinga, T.W.J. (author)
Objective: To analyse the effects of leflunomide and methotrexate treatment on matrix metalloproteinase (MMP) activity levels in a2 macroglobulin/MMP (α2M/MMP) complexes in the systemic circulation of rheumatoid arthritis (RA) patients. Methods: A total of 102 RA patients from a prospective, double-blind, randomised clinical trial comparing...
article 2008
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Jansen, N.W.D. (author), Roosendaal, G. (author), Bijlsma, J.W.J. (author), de Groot, J. (author), Theobald, M. (author), Lafeber, F.P.J.G. (author), TNO Kwaliteit van Leven (author)
Background: Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability. Objective: To examine the hypothesis that because degenerated cartilage has a limited repair capacity, it is more susceptible than healthy cartilage to blood-induced cartilage damage. Methods: Healthy,...
article 2008
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Opstelten, I.J. (author), de Groot, E. (author), Spiekman, M. (author), Energieonderzoek Centrum Nederland (author)
n.v.t.
conference paper 2008
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Taanman, M. (author), de Groot, A. (author), Kemp, R. (author), Verspagen, B. (author), TNO Bouw en Ondergrond (author)
We estimate the diffusion of micro cogeneration systems (MiCoGen) using hydrogen produced from natural gas in the Netherlands for the 2000-2050 period on the basis of economical factors. The diffusion is important for the transition to a hydrogen economy based on renewables, with natural gas paving the way for hydrogen from renewables. For three...
article 2008
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de Lange, D.J.J. (author), Dijk, J. (author), Schwering, P.B.W. (author), Kemp, R.A.W. (author), de Groot, J.F. (author), van den Broek, S.P. (author), TNO Defensie en Veiligheid (author)
In harbour environments operators should perform tasks as detection and classification. Present-day threats of smallobjects, as jet skis etc, should be detected, classified and recognized. Furthermore threat intention should be analysed. As harbour environments contain several hiding spaces, due to fixed and floating neutral objects, correct...
conference paper 2008
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de Groot, E.H. (author), Westerlaken, A.C. (author), TNO Bouw en Ondergrond (author)
article 2008
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Henneman, S. (author), Bildt, M.M. (author), de Groot, J. (author), Kuijpers-Jagtman, A.M. (author), Von den Hoff, J.W. (author)
The main cells in the periodontal ligament (PDL) are the fibroblasts, which play an important role in periodontal remodelling. Matrix metalloproteinases (MMPs) are largely responsible for the degradation of extracellular matrix proteins in the PDL. Previous studies have indicated that MMP production can be stimulated by the hormone relaxin. This...
article 2008
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Bulk-Bunschoten, A.M.W. (author), de Pasker-Jong, P.C.M. (author), van Wouwe, J.P. (author), de Groot, C.J. (author), TNO Kwaliteit van Leven (author)
This prospective study of 4438 infants (0-4 months) examined differences in infant-feeding patterns in relation to the ethnic origin of their mothers, based on the mother's native language: Dutch (87%), Turkish (4%), Moroccan (3%), other European languages (3%), and various other languages (4%). Breastfeeding at birth varied between 75% and 94%....
article 2008
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Intema, F. (author), de Groot, J. (author), Elshof, B. (author), Vianen, M.E. (author), Yocum, S. (author), Zuurmond, A. (author), Mastbergen, S.C. (author), Lafeber, F.P. (author), TNO Kwaliteit van Leven (author)
In studies aimed at local treatment of experimental osteoarthritis (OA) it is optimal to have an internal (untreated) OA control. Such an approach excludes interanimal variation, and allows paired statistical evaluation of treatment efficacy. For this purpose, we developed and characterized a bilateral version of the canine Groove model. We...
article 2008
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Bastiaansen-Jenniskens, Y.M. (author), Koevoet, W. (author), de Bart, A.C.W. (author), Zuurmond, A.-M. (author), Bank, R.A. (author), Verhaar, J.A.N. (author), de Groot, J. (author), van Osch, G.J.V.M. (author), TNO Kwaliteit van Leven (author)
Transforming growth factor beta (TGFβ) is often used in cartilage tissue engineering to increase matrix formation by cells with various phenotypes. However, adverse effects of TGFβ, such as extensive cross-linking in cultured fibroblasts, have also been reported. Our goal was to study effects of TGFβ on collagen cross-linking and evaluating the...
article 2008
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van Weeren, P.R. (author), Firth, E.C. (author), Brommer, H. (author), Hyttinen, M.M. (author), Helminen, H.J. (author), Rogers, C.W. (author), de Groot, J. (author), Brama, P.A.J. (author), TNO Kwaliteit van Leven (author)
article 2008
Searched for: mods_originInfo_dateIssued_s:"2008"
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