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Ethnic differences in the timely diagnosis of children with Type 1 diabetes mellitus in the Netherlands: Clinical presentation at onset

van Laar, J.J.N. (author), Grishchenko, M. (author), van Wouwe, J.P. (author), Stronks, K. (author), TNO Kwaliteit van Leven (author)

Aims: Little is known about ethnic differences in the timely diagnosis of Type 1 diabetes mellitus (Type 1 DM). This study aimed to assess ethnic inequalities in the timely diagnosis of Type 1 DM, as indicated by a more adverse clinical condition at onset. In addition, we assessed whether these differences could be explained by differences in...

article 2007

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RISKOFDERM: Predictions based in in vivo factors

Meuling, W.J.A. (author), van de Sandt, J.J.M. (author), van Hemmen, J.J. (author), TNO Kwaliteit van Leven (author)

article 2007

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Combination treatment for acute depression is superior only when psychotherapy is added to medication

Blom, M.B.J. (author), Jonker, J. (author), Dusseldorp, E. (author), Spinhoven, P. (author), Hoencamp, E. (author), Haffmans, P.M.J. (author), TNO Kwaliteit van Leven (author)

0-19, PZ.WI (wetenschappelijk Internationaal)

article 2007

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Fusion of heterogeneous speaker recognition systems in the STBU submission for the NIST Speaker Recognition Evaluation 2006

Brümmer, N. (author), Burget, L. (author), Černocký, J.H. (author), Glembek, O. (author), Grézl, F. (author), Karafiát, M. (author), van Leeuwen, D.A. (author), Matějka, P. (author), Schwarz, P. (author), Strasheim, A. (author), TNO Defensie en Veiligheid (author)

This paper describes and discusses the "STBU" speaker recognition system, which performed well in the NIST Speaker Recognition Evaluation 2006 (SRE). STBU is a consortium of four partners: Spescom DataVoice (Stellenbosch, South Africa), TNO (Soesterberg, The Netherlands), BUT (Brno, Czech Republic), and the University of Stellenbosch ...

article 2007

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Functional outcomes and participation in young adulthood for very preterm and very low birth weight infants: The Dutch project on preterm and small for gestational age infants at 19 years of age

Hille, E.T.M. (author), Weisglas-Kuperus, N. (author), van Goudoever, J.B. (author), Jacobusse, G.W. (author), Ens-Dokkum, M.H. (author), de Groot, L. (author), Wit, J.M. (author), Geven, W.B. (author), Kok, J.H. (author), de Kleine, M.J.K. (author), Kollée, L.A.A. (author), Mulder, A.L.M. (author), van Straaten, H.L.M. (author), de Vries, L.S. (author), van Weissenbruch, M.M. (author), Verloove-Vanhorick, S.P. (author), TNO Kwaliteit van Leven (author)

OBJECTIVE. Young adults who were born very preterm or with a very low birth weight remain at risk for physical and neurodevelopmental problems and lower academic achievement scores. Data, however, are scarce, hospital based, mostly done in small populations, and need additional confirmation. METHODS. Infants who were born at <32 weeks of...

article 2007

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Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products

Jeurissen, S.M.F. (author), Claassen, F.W. (author), Havlik, J. (author), Bouwmans, E.E. (author), Cnubben, N.H.P. (author), Sudhölter, E.J.R. (author), Rietjens, I.M.C.M. (author), van Beek, T.A. (author), TNO Kwaliteit van Leven (author)

An on-line HPLC screening method for detection of inhibitors of human cytochrome P450 1A2 in extracts was developed. HPLC separation of extracts is connected to a continuous methoxyresorufin-O-demethylation (MROD) assay in which recombinant human P450 1A2 converts methoxyresorufin to its fluorescent metabolite resorufin. The system was tested...

article 2007

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Rotterdam op weg naar 21 miljoen TEU in 2015

Verweij, C.A. (author)

article 2007

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Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein [2]

Hu, L. (author), Bovenschen, N. (author), Havekes, L.M. (author), van Vlijmen, B.J.M. (author), Tamsma, J.T. (author), TNO Kwaliteit van Leven (author)

article 2007

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Zonnewarmte heeft de toekomst in Nederland. Nu starten met de ontwikkeling van toekomstige systemen

van Helden, W. (author), Bakker, M. (author), van Amerongen, G. (author), Visser, H. (author)

De energiedoelstellingen om in 2020 een aandeel van 20 procent duurzame energie te realiseren met gelijktijdig een co2-uitstootreductie van 30% gelden op zowel Europees als notionaal niveau. Zonthermische energie is hierbij zeer belangrijk en kan nu al worden ingezet. Maar ook moet worden gestart met de ontwikkeling van zonthermische systemen...

article 2007

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One-generation reproductive toxicity study of DHA-rich oil in rats

Blum, R. (author), Kiy, T. (author), Waalkens-Berendsen, I. (author), Wong, A.W. (author), Roberts, A. (author), TNO Kwaliteit van Leven (author)

Polyunsaturated fatty acids, including docosahexaenoic acid (DHA), are natural constituents of the human diet. DHA-algal oil is produced through the use of the marine protist, Ulkenia sp. The reproductive toxicity of DHA-algal oil was assessed in a one-generation study. Rats were provided diets containing DHA-algal oil at concentrations of 1.5,...

article 2007

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Older persons afraid of falling reduce physical activity to prevent outdoor falls

Wijlhuizen, G.J. (author), de Jong, R. (author), Hopman-Rock, M. (author), TNO Kwaliteit van Leven (author)

Objective.: The aim of this study was to test the assumption that the level of outdoor physical activity mediates the relationship between fear of falling and actual outdoor falls according to the Task Difficulty Homeostasis Theory. Method.: A prospective follow-up study of 10 months conducted in the year 2000 in three municipalities in the...

article 2007

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Characteristics of bubble plumes, bubble-plume bubbles and waves from wind-steepened wave breaking

Leifer, I. (author), Caulliez, G. (author), de Leeuw, G. (author), TNO Defensie en Veiligheid (author)

Observations of breaking waves, associated bubble plumes and bubble-plume size distributions were used to explore the coupled evolution of wave-breaking, wave properties and bubble-plume characteristics. Experiments were made in a large, freshwater, wind-wave channel with mechanical wind-steepened waves and a wind speed of 13 m s- 1. Bubble...

article 2007

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Anthropometry and pancreatic cancer risk: An illustration of the importance of microscopic verification

Verhage, B.A.J. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

Using data collected of a large population-based cohort study, we studied the association between anthropometric factors and the risk of pancreatic cancer. Furthermore, we investigated whether these associations differ among microscopically confirmed pancreatic cancer (MCPC) cases and non-MCPC (NMCPC) cases. The Netherlands Cohort Study on Diet...

article 2007

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Analysis of benefits, opportunities, costs, and risks (BOCR) with the AHP+ANP: A critical validation

Wijnmalen, D.J.D. (author), TNO Defensie en Veiligheid (author)

This paper shows that the usual multiplicative synthesis of alternative priorities for benefits, opportunities, costs and risks, obtained from separate Analytic Hierarchy or Network models, can be ambiguous. The ratio of benefit and opportunity priorities to cost and risk priorities can be misleading when assessing the profitability of a project...

article 2007

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Young People's Exposure to Loud Music. A Summary of the Literature

Vogel, I. (author), Brug, J. (author), van der Ploeg, C.P.B. (author), Raat, H. (author), TNO Kwaliteit van Leven (author)

Objectives: This descriptive summary of the literature provides an overview of the available studies (published before October 2006) on sociodemographic, psychosocial, and other correlates of risk and protective behaviors for hearing loss in young people aged 12 to 25 years. Methods: Publications were identified by a structured search in PubMed,...

article 2007

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Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes

Jeurissen, S.M.F. (author), Punt, A. (author), Boersma, M.G. (author), Bogaards, J.J.P. (author), Fiamegos, Y.C. (author), Schilter, B. (author), van Bladeren, P.J. (author), Cnubben, N.H.P. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)

Human cytochrome P450 enzymes involved in the bioactivation of estragole to its proximate carcinogen 1′-hydroxyestragole were identified and compared to the enzymes of importance for 1′-hydroxylation of the related alkenylbenzenes methyleugenol and safrole. Incubations with Supersomes revealed that all enzymes tested, except P450 2C8, are...

article 2007

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Fitter met de sneltoets

van Lingen, P. (author), Blok, M. (author)

Uit een groot aantal studies blijkt dat veelvuldig gebruik van de computermuis vaak lichamelijk ongemak met zich meebrengt en soms tot lichamelijke klachten leidt. De meeste computeracties die mensen met de muis uitvoeren, zijn echter net zo goed met behulp van combinaties op het toetsenbord uit te voeren, de zgn. sneltoetsen. Het nadeel van...

article 2007

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Do familiarity and expectations change perception? Drivers’ glances and response to changes

Martens, M.H. (author), Fox, M. (author), TNO Defensie en Veiligheid (author)

The present study shows that repeated exposure to a road environment changes eye movement behaviour. In addition, repeated exposure may result in inadequate responses to unexpected changes in the road environment. Participants drove a low-cost simulator while their eye movements were recorded. With repeated exposure participants’ glances at...

article 2007

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Nieuwe impulsen voor de Delta om overstromingsrisico's te beperken

Immink, I. (author), Dircke, P. (author)

article 2007

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TNO MF-SWIFT

Schmeitz, A.J.C. (author), Besselink, I.J.M. (author), Jansen, S.T.H. (author), TNO Industrie en Techniek (author)

In this paper, an overview of the TNO MF-SWIFT model is given. After an historical overview of the model development and the intended range of application, the model is described briefly. Next, the implementation in multibody and other simulation software is discussed, including also the available road models. After that, the parameterization of...

article 2007